| Accession | ARO:3001253 |
| Definition | Phenelfamycin E was isolated from two environmental isolates called AB999F-80 and AB1047T-33. They were both identified as Streptomyces violaceoniger strains. Both these strains were found to produce phenelfamycins A-F and unphenelfamycin. Phenelfamycin E has a trisaccaride moeity and is isomeric with phenelfamycin F. All phenelfamycins were selected due to their activity against anaerobic bacteria, especially Clostridioides difficile. Phenelfamycin E and F are the most potent of the phenelfamycins. |
| Drug Class | elfamycin antibiotic |
| Classification | 3 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Publications | Hochlowski JE, et al. 1988. J Antibiot (Tokyo) 41(10): 1300-1315. Phenelfamycins, a novel complex of elfamycin-type antibiotics. II. Isolation and structure determination. (PMID 3192490) Jackson M, et al. 1988. J Antibiot (Tokyo) 41(10): 1293-1299. Phenelfamycins, a novel complex of elfamycin-type antibiotics. I. Discovery, taxonomy and fermentation. (PMID 3192489) Swanson RN, et al. 1989. J Antibiot (Tokyo) 42(1): 94-101. Phenelfamycins, a novel complex of elfamycin-type antibiotics. III. Activity in vitro and in a hamster colitis model. (PMID 2921230) |
