kirromycin [Antibiotic]

Download Sequences

Accession ARO:3001234
DefinitionKirromycin, also known as mocimycin, is the representative molecule of its own class of elfamycins which is composed of more than 10 analogs. Kirromycin binds to the domain 1,2 interface of elongation factor Tu. This interaction maintains the EF-Tu*GTP conformation even after GTP is hydrolyzed to GDP. EF-Tu*GDP normally releases aa-tRNA and then exits the ribosome; however, kirromycin*EF-Tu*GDP*aa-tRNA forms a strong complex and remains bound to the ribosome, prohibits translocation of the peptide chain and translation is halted.
Drug Classelfamycin antibiotic
Classification3 ontology terms | Show
Parent Term(s)1 ontology terms | Show
2 ontology terms | Show

Wolf H, et al. 1974. Proc Natl Acad Sci U S A 71(12): 4910-4914. Kirromycin, an inhibitor of protein biosynthesis that acts on elongation factor Tu. (PMID 4373734)

Hall CC, et al. 1989. Antimicrob Agents Chemother 33(3): 322-325. Effects of elfamycins on elongation factor Tu from Escherichia coli and Staphylococcus aureus. (PMID 2499247)

Parmeggiani A and Swart GW. 1985. Annu Rev Microbiol 39: 557-577. Mechanism of action of kirromycin-like antibiotics. (PMID 3904612)

Abdulkarim F, et al. 1994. FEBS Lett 352(2): 118-122. Mutations to kirromycin resistance occur in the interface of domains I and III of EF-Tu.GTP. (PMID 7925958)

Fischer E, et al. 1977. Proc Natl Acad Sci U S A 74(10): 4341-4345. Elongation factor Tu resistant to kirromycin in an Escherichia coli mutant altered in both tuf genes. (PMID 337296)

Cappellano C, et al. 1997. Microbiology 143(PT 2): 617-624. Natural kirromycin resistance of elongation factor Tu from the kirrothricin producer Streptomyces cinnamoneus. (PMID 9043138)

Barber J, et al. 1988. J Antibiot (Tokyo) 41(2): 202-206. The molecular basis of kirromycin (mocimycin) action; a 1H NMR study using deuterated elongation factor Tu. (PMID 3356609)