teixobactin [Antibiotic]

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Ontology CARD's Antibiotic Resistance Ontology
Accession ARO:3003241
DefinitionTeixobactin is a peptide antibiotic isolated from the Gram-negative bacteria, Eleftheria terrae. It inhibits the synthesis of peptidoglycan by interacting with peptidoglycan precursor, Lipid II and Lipid III.
SMILESCC[C@@H](C)[C@@H](NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C[C@H]2CNC(=N)N2)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O[C@H]1C)[C@@H](C)CC
PubChem86341926
ChEBI84192
ChEMBLCHEMBL3977597
Drug Classpeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ peptide antibiotic [Drug Class]
Sub-Term(s)
2 ontology terms | Show
+ Lipid II targeted_by_antibiotic
+ Lipid III targeted_by_antibiotic
Publications

Ling LL, et al. 2015. Nature 517(7535): 455-459. A new antibiotic kills pathogens without detectable resistance. (PMID 25561178)

Curator Acknowledgements
Curator Description Most Recent Edit