| Accession | ARO:3003451 |
| Synonym(s) | Rv0343 |
| CARD Short Name | Mtub_iniC_EMB |
| Definition | Specific mutations that occurs on Mycobacterium tuberculosis iniC causing it to be ethambutol resistant. |
| AMR Gene Family | Ethambutol resistant iniC |
| Drug Class | polyamine antibiotic |
| Resistance Mechanism | antibiotic efflux, antibiotic target alteration |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Sequence Variants | Mycobacterium tuberculosiswgs |
| Classification | 13 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + antibiotic molecule + subunit of efflux pump conferring antibiotic resistance + polyamine antibiotic [Drug Class] + antibiotic resistant gene variant or mutant + Antibiotic resistant iniC + ethambutol [Antibiotic] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic ethambutol [Antibiotic] + Ethambutol resistant iniC [AMR Gene Family] |
| Publications | Ramaswamy SV, et al. 2000. Antimicrob Agents Chemother 44(2): 326-336. Molecular genetic analysis of nucleotide polymorphisms associated with ethambutol resistance in human isolates of Mycobacterium tuberculosis. (PMID 10639358) Ramaswamy SV, et al. 2003. Antimicrob. Agents Chemother. 47(4):1241-50 Single nucleotide polymorphisms in genes associated with isoniazid resistance in Mycobacterium tuberculosis. (PMID 12654653) Zhang M, et al. 2005. J. Clin. Microbiol. 43(11):5477-82 Detection of mutations associated with isoniazid resistance in Mycobacterium tuberculosis isolates from China. (PMID 16272473) |
Prevalence of Mycobacterium tuberculosis iniC mutant conferring resistance to ethambutol among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Mycobacterium tuberculosis | 0% | 0% | 0.17% | 0% | 0% |
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 900
PubMed: mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). CRyPTIC: mutation data acquired from the CRyPTIC catalog, evaluated as resistant (R), susceptible (S), or undetermined (U). ReSeqTB: mutation data acquired from the ReSeqTB catalog, evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. WHO: mutation data acquired from the WHO 2023 catalog, evaluated as resistant (R), susceptible (S), or undetermined (U).| Mutation | Mutation type | PubMed | ReSeqTB | CRyPTIC | WHO |
|---|---|---|---|---|---|
| +nt79:t | insertion mutation from nucleotide sequence | PMID:16272473 | no data | no data | no data |
| W83G | single resistance variant | PMID:12654653 | no data | no data | no data |
| +nt98:a | insertion mutation from nucleotide sequence | PMID:16272473 | no data | no data | no data |
| P248A | single resistance variant | PMID:10639358 | no data | no data | no data |
| Q351Ter | nonsense mutation | PMID:10639358 | no data | no data | no data |
| Curator | Description | Most Recent Edit |
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