| Accession | ARO:3003890 |
| CARD Short Name | Ecol_UhpT_FOF |
| Definition | Mutations to the active importer UhpT, which is involved with the uptake of many phosphorylated sugars, confer resistance to fosfomycin by reducing import of the drug into the bacteria. |
| AMR Gene Family | antibiotic-resistant UhpT |
| Drug Class | phosphonic acid antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Resistomes with Sequence Variants | Citrobacter amalonaticusg+wgs, Citrobacter freundiig+wgs, Citrobacter koserig+wgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniig+wgs, Citrobacter youngaeg+wgs, Enterobacter asburiaeg+wgs, Enterobacter cancerogenusg+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeig+wgs, Enterobacter roggenkampiig+wgs, Escherichia albertiig+wgs, Escherichia colig+wgs, Escherichia fergusoniiwgs, Escherichia marmotaeg+wgs, Klebsiella aerogenesg+wgs, Klebsiella huaxiensisg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+wgs, Raoultella planticolag+wgs, Salmonella bongorig+wgs, Salmonella entericag+wgs, Shigella boydiig+wgs, Shigella dysenteriaewgs, Shigella flexnerig+wgs, Shigella sonneiwgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + phosphonic acid antibiotic [Drug Class] + antibiotic resistant gene variant or mutant |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic fosfomycin [Antibiotic] + antibiotic resistant gene variant or mutant + antibiotic-resistant UhpT [AMR Gene Family] |
| Publications | Takahata S, et al. 2010. Int J Antimicrob Agents 35(4): 333-337. Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coli. (PMID 20071153) |
Prevalence of Escherichia coli UhpT with mutation conferring resistance to fosfomycin among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Citrobacter amalonaticus | 90.91% | 0% | 78.18% | 0% |
| Citrobacter freundii | 100% | 0% | 50.29% | 0% |
| Citrobacter koseri | 100% | 0% | 49.55% | 0% |
| Citrobacter portucalensis | 77.78% | 0% | 62.16% | 0% |
| Citrobacter werkmanii | 100% | 0% | 61.54% | 0% |
| Citrobacter youngae | 66.67% | 0% | 100% | 0% |
| Enterobacter asburiae | 35.48% | 0% | 29.25% | 0% |
| Enterobacter cancerogenus | 100% | 0% | 92.86% | 0% |
| Enterobacter chengduensis | 0% | 0% | 36% | 0% |
| Enterobacter cloacae | 73.21% | 1.12% | 56.23% | 0% |
| Enterobacter hormaechei | 97.84% | 0.13% | 66.51% | 0% |
| Enterobacter kobei | 100% | 0% | 66.38% | 0% |
| Enterobacter roggenkampii | 95.35% | 0% | 58.63% | 0% |
| Escherichia albertii | 98.57% | 0% | 62.58% | 0% |
| Escherichia coli | 8.43% | 0% | 10.63% | 0% |
| Escherichia fergusonii | 0% | 0% | 2.17% | 0% |
| Escherichia marmotae | 100% | 0% | 70.83% | 0% |
| Klebsiella aerogenes | 100% | 0% | 79.94% | 0% |
| Klebsiella huaxiensis | 100% | 0% | 66.67% | 0% |
| Klebsiella michiganensis | 98.39% | 0% | 69.15% | 0% |
| Klebsiella oxytoca | 97.44% | 0% | 75.21% | 0% |
| Klebsiella pneumoniae | 98.76% | 0.01% | 57.1% | 0% |
| Klebsiella quasipneumoniae | 100% | 0% | 73.68% | 0% |
| Raoultella planticola | 100% | 0% | 94.87% | 0% |
| Salmonella bongori | 100% | 0% | 94.74% | 0% |
| Salmonella enterica | 93.19% | 0% | 79.71% | 0% |
| Shigella boydii | 6.67% | 0% | 4.44% | 0% |
| Shigella dysenteriae | 0% | 0% | 20% | 0% |
| Shigella flexneri | 2% | 0% | 0.16% | 0% |
| Shigella sonnei | 0% | 0% | 0.22% | 0% |
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 850
Legend:
Published Variants:
| PMID: 20071153 | E350Q |