microcin J25 [Antibiotic]

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Accession ARO:3003951
DefinitionMicrocin J25 is a peptide antibiotic that inhibits transcription by bacterial RNA polymerase. MccJ25 is produced by Escherichia coli strains that harbor a plasmid-borne antibiotic-synthesis and antibiotic-export cassette, consisting of a gene for MccJ25 precursor (a 58 residue linear peptide), two genes for factors that process MccJ25 precursor into MccJ25, and one gene for export of MccJ25.
Drug Classpeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ peptide antibiotic [Drug Class]
1 ontology terms | Show
+ YojI confers_resistance_to_antibiotic

Mukhopadhyay J, et al. 2004. Mol. Cell 14(6):739-51 Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel. (PMID 15200952)