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Accession VIRO:0000044
DefinitionToxin produced by Staphylococcus aureus. Upon binding the cell-surface, seven monomers assemble and form a homoheptamer beta-barrel which matures and inserts itself into the membrane of the cell forming a transmembrane channel. Allows the flow of molecules smaller than 2kD, including ions such as K+ and Ca2+ which often lead to cell lysis.
Classification9 ontology terms | Show
Parent Term(s)1 ontology terms | Show
1 ontology terms | Show
+ Vibrio cholerae cytolysin structurally_homologous_to

Inoshima I, et al. 2011. Nat. Med. 17(10):1310-4 A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. (PMID 21926978)

Vandenesch F, et al. 2012. Front Cell Infect Microbiol 2:12 Staphylococcus aureus hemolysins, bi-component leukocidins, and cytolytic peptides: a redundant arsenal of membrane-damaging virulence factors?. (PMID 22919604)

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