Vibrio cholerae cytolysin

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Accession VIRO:0000153
Synonym(s)hlyA VCC
DefinitionCoded by the hlyA gene. Vibrio cholerae cytolysin (VCC) is a pore-forming toxin that acts on the target cells by forming transmembrane oligomeric β-barrel pores, thereby leading to permeabilization of the target cell membranes and as a result significantly facilitates intestinal colonization in mouse models
Classification8 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ Hemolysin toxins [Virulence Factor]
+ structurally_homologous_to alpha-hemolysin
+ stoichiometrically_homologous_to aerolysin
+ stoichiometrically_homologous_to anthrax toxin

Valeva A, et al. 2005. Mol. Microbiol. 57(1):124-31 Identification of the membrane penetrating domain of Vibrio cholerae cytolysin as a beta-barrel structure. (PMID 15948954)

Dal Peraro M, et al. 2016. Nat. Rev. Microbiol. 14(2):77-92 Pore-forming toxins: ancient, but never really out of fashion. (PMID 26639780)

De S, et al. 2011. Proc. Natl. Acad. Sci. U.S.A. 108(18):7385-90 Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins. (PMID 21502531)

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