Panton-Valentine Leukocidin

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Accession VIRO:0000065
DefinitionPanton-Valentine Leukocidin (PVL) is a pore-forming toxin. Together with γ-hemolysin and other leukocidins such as LukE-LukD, PVL belongs to the family of bicomponent synergohymenotropic toxins. The connection between this toxin and disease remains unclear, however, certain studies have shown that PVL tends to exacerbate the progression of other diseases
Classification11 ontology terms | Show
Parent Term(s)2 ontology terms | Show
2 ontology terms | Show
+ LukF-PV part_of
+ LukS-PV part_of

Montagnani C, et al. 2013. Acta Paediatr. 102(6):e284-7 Severe infections caused by Panton-Valentine leukocidin-positive Staphylococcus aureus in infants: report of three cases and review of literature. (PMID 23551699)

DuMont AL, et al. 2014. Trends Microbiol. 22(1):21-7 Cell targeting by the Staphylococcus aureus pore-forming toxins: it's not just about lipids. (PMID 24231517)

Seilie ES, et al. 2017. Semin. Cell Dev. Biol. 72:101-116 Staphylococcus aureus pore-forming toxins: The interface of pathogen and host complexity. (PMID 28445785)