Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3004016 |
Synonym(s) | Lorabid Loracarbefum |
Definition | Loracarbef is a second-generation cephalosporin (carbacephem) and broad spectrum beta-lactam antibiotic. Loracarbef inhibits PBPs through binding, disrupting peptidoglycan cell wall cross-linkage and resulting in cell death. |
SMILES | N[C@@H](C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Cl)CC[C@H]12)c1ccccc1.O |
PubChem | 5284585 |
ChEBI | 47544 |
CAS | 76470-66-1 |
ChEMBL | CHEMBL1200610 |
Drug Class | cephalosporin |
Classification | 4 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show |
Sub-Term(s) | 1 ontology terms | Show + beta-lactam sensitive penicillin-binding protein targeted_by_antibiotic |
Publications | Jones RN, et al. 1987. Eur. J. Clin. Microbiol. 6(5):570-1 Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem LY163892. (PMID 3501757) Force RW, et al. 1993. Ann Pharmacother 27(3):321-9 Loracarbef: a new orally administered carbacephem antibiotic. (PMID 8453172) |
Curator | Description | Most Recent Edit |
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