dermonecrotic toxin

Accession VIRO:0000101
DefinitionDermonecrotic toxin (Dnt) from Bordetella bronchiseptica is an A-B type toxin composed of N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain. Dnt is a Dermonecrosis-inducing toxin stimulates the assembly of actin stress fibers and focal adhesions by deamidating or polyaminating small GTPase Rho.
Classification12 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ Bordetella bronchiseptica factors of virulence
+ A-B toxin
+ participates_in Deamidation [Virulence Mechanism]

Fukui-Miyazaki A, et al. 2011. Microbiol. Immunol. 55(3):154-9 Bordetella dermonecrotic toxin binds to target cells via the N-terminal 30 amino acids. (PMID 21204952)

Private model - RGI is not currently using this model.