ADP-Ribosylation [Virulence Mechanism]

Accession VIRO:0000305
DefinitionMechanism for intracellularly active bacterial toxins that target rho proteins in order to ultimately affect actin polymerization within host cells as a toxic effect. Involves the splitting of an NAD+ (nicotinamide adenine dinucleotide) molecule and the transfer of its ADP-ribose moiety onto the target protein residue, releasing nicotinamide as a byproduct. The toxic effect is generally a change in the functionality of the target protein depending on which residue was targeted and modified, resulting in either inhibition or enhancement of polymerization.
Classification1 ontology terms | Show
Parent Term(s)1 ontology terms | Show
2 ontology terms | Show
+ Rho-protein activator toxins [Virulence Factor]
+ Rho-protein inactivator toxins [Virulence Factor]

Aktories K, et al. 2017. Handb Exp Pharmacol 235:179-206 ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins. (PMID 27316913)