| Accession | VIRO:0000305 |
| Definition | Mechanism for intracellularly active bacterial toxins that target rho proteins in order to ultimately affect actin polymerization within host cells as a toxic effect. Involves the splitting of an NAD+ (nicotinamide adenine dinucleotide) molecule and the transfer of its ADP-ribose moiety onto the target protein residue, releasing nicotinamide as a byproduct. The toxic effect is generally a change in the functionality of the target protein depending on which residue was targeted and modified, resulting in either inhibition or enhancement of polymerization. |
| Classification | 1 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show |
| Sub-Term(s) | 2 ontology terms | Show + Rho-protein activator toxins [Virulence Factor] + Rho-protein inactivator toxins [Virulence Factor] |
| Publications | Aktories K, et al. 2017. Handb Exp Pharmacol 235:179-206 ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins. (PMID 27316913) |