Accession | VIRO:0000157 |
Definition | YaxAB from Yersinia enterocolitica is a pore-forming toxin that mediates cell death occurs via osmotic lysis through the formation of distinct membrane pores. Both YaxA and YaxB are required for cytotoxic activity. Similar toxins are HBL-B from Bacillus cereus and HlyE from Escherichia coli |
Classification | 19 ontology terms | Show + process or component of pathogenesis biology or chemistry + biological effect of virulence + virulence factor + colonization + host cell damaging + invasion + toxin [Virulence Factor] + invasin [Virulence Factor] + lysis factor + exotoxin + hemolysin + organism associated with virulence + pore-forming toxin + molecular mechanism of bacterial virulence + alpha pore-forming toxin [Virulence Factor] + Yersinia-specific virulence + ClyA toxins [Virulence Factor] + Yersinia enterocolitica factors of virulence + mechanism of toxicity [Virulence Mechanism] |
Parent Term(s) | 5 ontology terms | Show + ClyA toxins [Virulence Factor] + Yersinia enterocolitica factors of virulence + part_of YaxAB + toxin subunit + mechanism of toxicity [Virulence Mechanism] |
Publications | Wagner NJ, et al. 2013. Infect. Immun. 81(11):4208-19 YaxAB, a Yersinia enterocolitica pore-forming toxin regulated by RovA. (PMID 24002058) |
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