BPI [Antibiotic]

Accession ARO:3004121
DefinitionBactericidal/permeability-increasing (BPI) protein is a member of a new generation of proteins known as super-antibiotics that are implicated as endotoxin neutralising agents. The potent (nM) cytotoxicity of BPI is limited to gram-negative bacteria (GNB), reflecting the high affinity (<10 nM) of BPI for bacterial lipopolysaccharides (LPS). Binding of BPI to live bacteria via LPS causes immediate growth arrest, actual killing coincides with later damage to the inner membrane.
Drug Classpeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ peptide antibiotic [Drug Class]
2 ontology terms | Show
+ Vibrio cholerae OmpU confers_resistance_to_antibiotic
+ Vibrio cholerae OmpT confers_resistance_to_antibiotic

Elsbach P, et al. 1998. J. Leukoc. Biol. 64(1):14-8 The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense. (PMID 9665269)

Qin WY, et al. 2017. Gene 616:45-51 New insights into the codon usage patterns of the bactericidal/permeability-increasing (BPI) gene across nine species. (PMID 28336464)