| Accession | ARO:3004121 |
| Definition | Bactericidal/permeability-increasing (BPI) protein is a member of a new generation of proteins known as super-antibiotics that are implicated as endotoxin neutralising agents. The potent (nM) cytotoxicity of BPI is limited to gram-negative bacteria (GNB), reflecting the high affinity (<10 nM) of BPI for bacterial lipopolysaccharides (LPS). Binding of BPI to live bacteria via LPS causes immediate growth arrest, actual killing coincides with later damage to the inner membrane. |
| Drug Class | peptide antibiotic |
| Classification | 2 ontology terms | Show |
| Parent Term(s) | 1 ontology terms | Show + peptide antibiotic [Drug Class] |
| Sub-Term(s) | 2 ontology terms | Show + Vibrio cholerae OmpU confers_resistance_to_antibiotic + Vibrio cholerae OmpT confers_resistance_to_antibiotic |
| Publications | Elsbach P, et al. 1998. J. Leukoc. Biol. 64(1):14-8 The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense. (PMID 9665269) Qin WY, et al. 2017. Gene 616:45-51 New insights into the codon usage patterns of the bactericidal/permeability-increasing (BPI) gene across nine species. (PMID 28336464) |
