| Accession | ARO:3004117 |
| CARD Short Name | Vcho_OmpU |
| Definition | A ToxR-Regulated outer membrane porin. In Vibrio cholerae, ToxR controls resistance to P2 (a BPI-derived antimicrobial peptide) by regulating the production of OmpU. OmpU also confers resistance to polymyxin B sulfate. |
| AMR Gene Family | General Bacterial Porin with reduced permeability to peptide antibiotics |
| Drug Class | peptide antibiotic |
| Resistance Mechanism | reduced permeability to antibiotic |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + reduced permeability to antibiotic [Resistance Mechanism] + determinant of antibiotic resistance + antibiotic molecule + protein modulating permeability to antibiotic + peptide antibiotic [Drug Class] + General Bacterial Porin (GBP) |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic BPI [Antibiotic] + General Bacterial Porin with reduced permeability to peptide antibiotics [AMR Gene Family] |
| Publications | Mathur J, et al. 2004. Infect. Immun. 72(6):3577-83 The Vibrio cholerae ToxR-regulated porin OmpU confers resistance to antimicrobial peptides. (PMID 15155667) Paauw A, et al. 2014. BMC Microbiol. 14:158 OmpU as a biomarker for rapid discrimination between toxigenic and epidemic Vibrio cholerae O1/O139 and non-epidemic Vibrio cholerae in a modified MALDI-TOF MS assay. (PMID 24943244) |
Prevalence of Vibrio cholerae OmpU among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| No prevalence data | ||||
Model Type: protein knockout model
Model Definition: Protein Knockout Models (PKM) reflect resistance by the absence of a gene product, most often deletion of a gene involved in antibiotic import, such as Vibrio cholerae OmpT. Like Protein Homolog Models (PHMs), PKMs include a reference sequence and a bitscore cut-off for detection using BLASTP but instead are designed to only report lack of detection under Perfect or Strict criteria. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff. This model type is still under development and not currently supported by the Resistance Gene Identifier (RGI) software.
Bit-score Cut-off (blastP): 600
Type of Antibiotic Resistance: Intrinsic or chromosomally-encoded