AMPylation [Virulence Mechanism]

Accession VIRO:0000317
DefinitionMechanism for intracellularly active bacterial toxins that target rho proteins in order to ultimately affect actin polymerization within host cells as a toxic effect. Involves the addition of an adenosine 5'-monophosphate (AMP) to a protein residue in order to inactivate the target protein. Generally results in the inhibition of actin polymerization within the host cells.
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show

Yarbrough ML, et al. 2009. Science 323(5911): 269-272. AMPylation of Rho GTPases by Vibrio VopS disrupts effector binding and downstream signaling. (PMID 19039103)