Proteolytic cleavage [Virulence Mechanism]

Accession VIRO:0000318
DefinitionMechanism for intracellularly active bacterial toxins that target rho proteins in order to ultimately affect actin polymerization within host cells as a toxic effect. Involves the cleavage of a rho peptide sequence in order to inactivate its function. Generally results in the inhibition of actin polymerization within host cells.
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show

Shao F, et al. 2002. Cell 109(5):575-88 A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis. (PMID 12062101)