SopE2

Accession VIRO:0000385
DefinitionSopeE2 is a toxin utilized by Salmonella enterica. It is injected by the pathogen through a type III secretion system and exerts its toxic effect by inducing both cytoskeletal and nuclear responses by stimulating GDP/GTP nucleotide exchange in Rho family of small molecular weight GTP-binding proteins. It is also essential for bacterial entry into host cell
Classification14 ontology terms | Show
Parent Term(s)4 ontology terms | Show
Publications

Hardt WD, et al. 1998. Cell 93(5):815-26 S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. (PMID 9630225)

Friebel A, et al. 2001. J. Biol. Chem. 276(36):34035-40 SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell. (PMID 11440999)

Aktories K, et al. 2017. Handb Exp Pharmacol 235:179-206 ADP-Ribosylation and Cross-Linking of Actin by Bacterial Protein Toxins. (PMID 27316913)

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