Accession VIRO:0000422
Synonym(s)CNF1 CNF╬│ cytotoxic necrotizing factor
Definitioncytotoxic necrotizing factor toxin from Yersinia pseudotuberculosis. This toxin activates the host Rho GTPase by deamidating the Gln63 residue and contributes to the activity of the Yop proteins. There is evidence to suggest that Y. pseudotuberculosis secretes membrane vesicles (MVs) in order to mediate the transfer of this toxin into host cells
Classification12 ontology terms | Show
Parent Term(s)3 ontology terms | Show
+ Yersinia pseudotuberculosis factors of virulence
+ participates_in Deamidation [Virulence Mechanism]
+ Rho-protein activator toxins [Virulence Factor]

Monnappa AK, et al. 2018. Sci Rep 8(1):14186 The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFy) is Carried on Extracellular Membrane Vesicles to Host Cells. (PMID 30242257)

Private model - RGI is not currently using this model.