Accession | VIRO:0000422 |
Synonym(s) | CNF1 CNFγ cytotoxic necrotizing factor |
Definition | cytotoxic necrotizing factor toxin from Yersinia pseudotuberculosis. This toxin activates the host Rho GTPase by deamidating the Gln63 residue and contributes to the activity of the Yop proteins. There is evidence to suggest that Y. pseudotuberculosis secretes membrane vesicles (MVs) in order to mediate the transfer of this toxin into host cells |
Classification | 12 ontology terms | Show + process or component of pathogenesis biology or chemistry + biological effect of virulence + host cell damaging + virulence factor + toxin [Virulence Factor] + molecular mechanism of bacterial virulence + exotoxin + organism associated with virulence + Actin-affecting toxins [Virulence Mechanism] + ADP-Ribosylation [Virulence Mechanism] + Rho-protein activator toxins [Virulence Factor] + Yersinia-specific virulence |
Parent Term(s) | 3 ontology terms | Show + Yersinia pseudotuberculosis factors of virulence + participates_in Deamidation [Virulence Mechanism] + Rho-protein activator toxins [Virulence Factor] |
Publications | Monnappa AK, et al. 2018. Sci Rep 8(1):14186 The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFy) is Carried on Extracellular Membrane Vesicles to Host Cells. (PMID 30242257) |
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