Streptolysin O

Accession VIRO:0000561
DefinitionStreptolysin O (SLO) is a pore-forming toxin with cholesterol-dependent cytolytic and hemolytic properties. Its primary function is to form large pore in host cell membranes as a method of immune evasion by inducing caspase-dependent apoptosis in macrophage, neutrophil and epithelial cells. However, its toxic properties also contribute to tissue damage at the site of infection
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show

Walker MJ, et al. 2014. Clin. Microbiol. Rev. 27(2):264-301 Disease manifestations and pathogenic mechanisms of Group A Streptococcus. (PMID 24696436)

Private model - RGI is not currently using this model.