Cholesterol-dependent cytolysin toxins

Accession VIRO:0000239
Synonym(s)CDC CDCs
DefinitionA subclass of beta pore-forming toxins. Characterized by their binding to particularly cholesterol-rich membranes and forming relatively large transmembrane pores comprised of 35-50 monomers. Produced by over 20 species of gram-positive pathogens
Classification7 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ beta pore-forming toxin [Virulence Mechanism]
4 ontology terms | Show

Christie MP, et al. 2018. Biophys Rev 10(5):1337-1348 Cholesterol-dependent cytolysins: from water-soluble state to membrane pore. (PMID 30117093)

Lukoyanova N, et al. 2016. J. Cell. Sci. 129(11):2125-33 The membrane attack complex, perforin and cholesterol-dependent cytolysin superfamily of pore-forming proteins. (PMID 27179071)

Marriott HM, et al. 2008. Curr. Mol. Med. 8(6):497-509 Pneumolysin: a double-edged sword during the host-pathogen interaction. (PMID 18781957)