| Accession | ARO:3004937 |
| Synonym(s) | rrl |
| CARD Short Name | Mtub_23S_CAP |
| Definition | Point mutations in 23S rRNA of Mycobacterium tuberculosis can confer resistance to capreomycin. |
| AMR Gene Family | 23s rRNA with mutation conferring resistance to aminoglycoside antibiotics |
| Drug Class | aminoglycoside antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 10 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic resistant gene variant or mutant + rRNA with mutation conferring antibiotic resistance + antibiotic molecule + 23S rRNA with mutation conferring antibiotic resistance + aminoglycoside antibiotic [Drug Class] |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic capreomycin [Antibiotic] + 23s rRNA with mutation conferring resistance to aminoglycoside antibiotics [AMR Gene Family] |
| Publications | Johansen SK, et al. 2006. Mol Cell 23(2):173-82 Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs. (PMID 16857584) Ezewudo M, et al. 2018. Sci Rep 8(1):15382 Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. (PMID 30337678) |
Private model - RGI is not currently using this model.
| Curator | Description | Most Recent Edit |
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