Mycobacterium tuberculosis ald mutations confer resistance to cycloserine

Accession ARO:3004945
CARD Short NameMtub_ald_DCS
DefinitionMutations in the ald gene that contribute to or confer resistance to cycloserine.
AMR Gene Familycycloserine resistant ald
Drug Classcycloserine-like antibiotic
Resistance Mechanismantibiotic target alteration
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic cycloserine [Antibiotic]
+ cycloserine resistant ald [AMR Gene Family]
Publications

Desjardins CA, et al. 2016. Nat Genet 48(5):544-51 Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance. (PMID 27064254)

Ezewudo M, et al. 2018. Sci Rep 8(1):15382 Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. (PMID 30337678)

Resistomes

Prevalence of Mycobacterium tuberculosis ald mutations confer resistance to cycloserine among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
No prevalence data


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 700


>gb|NP_217296.1|+|Mycobacterium tuberculosis ald mutations confer resistance to cycloserine [Mycobacterium tuberculosis H37Rv]
MRVGIPTETKNNEFRVAITPAGVAELTRRGHEVLIQAGAGEGSAITDADFKAAGAQLVGTADQVWADADLLLKVKEPIAAEYGRLRHGQI
LFTFLHLAASRACTDALLDSGTTSIAYETVQTADGALPLLAPMSEVAGRLAAQVGAYHLMRTQGGRGVLMGGVPGVEPADVVVIGAGTAG
YNAARIANGMGATVTVLDINIDKLRQLDAEFCGRIHTRYSSAYELEGAVKRADLVIGAVLVPGAKAPKLVSNSLVAHMKPGAVLVDIAID
QGGCFEGSRPTTYDHPTFAVHDTLFYCVANMPASVPKTSTYALTNATMPYVLELADHGWRAACRSNPALAKGLSTHEGALLSERVATDLG
VPFTEPASVLA


>gb|NC_000962.3|+|3086820-3087935|Mycobacterium tuberculosis ald mutations confer resistance to cycloserine [Mycobacterium tuberculosis H37Rv]
ATGCGCGTCGGTATTCCGACCGAGACCAAAAACAACGAATTCCGGGTGGCCATCACCCCGGCCGGCGTCGCGGAACTAACCCGTCGTGGC
CATGAGGTGCTCATCCAGGCAGGTGCCGGAGAGGGCTCGGCTATCACCGACGCGGATTTCAAGGCGGCAGGCGCGCAACTGGTCGGCACC
GCCGACCAGGTGTGGGCCGACGCTGATTTATTGCTCAAGGTCAAAGAACCGATAGCGGCGGAATACGGCCGCCTGCGACACGGGCAGATC
TTGTTCACGTTCTTGCATTTGGCCGCGTCACGTGCTTGCACCGATGCGTTGTTGGATTCCGGCACCACGTCAATTGCCTACGAGACCGTC
CAGACCGCCGACGGCGCACTACCCCTGCTTGCCCCGATGAGCGAAGTCGCCGGTCGACTCGCCGCCCAGGTTGGCGCTTACCACCTGATG
CGAACCCAAGGGGGCCGCGGTGTGCTGATGGGCGGGGTGCCCGGCGTCGAACCGGCCGACGTCGTGGTGATCGGCGCCGGCACCGCCGGC
TACAACGCAGCCCGCATCGCCAACGGCATGGGCGCGACCGTTACGGTTCTAGACATCAACATCGACAAACTTCGGCAACTCGACGCCGAG
TTCTGCGGCCGGATCCACACTCGCTACTCATCGGCCTACGAGCTCGAGGGTGCCGTCAAACGTGCCGACCTGGTGATTGGGGCCGTCCTG
GTGCCAGGCGCCAAGGCACCCAAATTAGTCTCGAATTCACTTGTCGCGCATATGAAACCAGGTGCGGTACTGGTGGATATAGCCATCGAC
CAGGGCGGCTGTTTCGAAGGCTCACGACCGACCACCTACGACCACCCGACGTTCGCCGTGCACGACACGCTGTTTTACTGCGTGGCGAAC
ATGCCCGCCTCGGTGCCGAAGACGTCGACCTACGCGCTGACCAACGCGACGATGCCGTATGTGCTCGAGCTTGCCGACCATGGCTGGCGG
GCGGCGTGCCGGTCGAATCCGGCACTAGCCAAAGGTCTTTCGACGCACGAAGGGGCGTTACTGTCCGAACGGGTGGCCACCGACCTGGGG
GTGCCGTTCACCGAGCCCGCCAGCGTGCTGGCCTGA

Curator Acknowledgements
Curator Description Most Recent Edit