Accession | ARO:3000760 |
Definition | Cycloserine is an anti-mycobacterial agent, and is active against enterobacteria, streptococci, M. tuberculosis, Staphylococcus aureus, and many Gram-negative and Gram-positive bacteria. It inhibits cell wall biosynthesis. |
SMILES | N/A |
PubChem | 6234 |
Drug Class | cycloserine-like antibiotic |
Classification | 2 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show + cycloserine-like antibiotic [Drug Class] |
Sub-Term(s) | 5 ontology terms | Show + cycloserine sensitive alr targeted_by_antibiotic + cycloserine sensitive D-alanine synthetase targeted_by_antibiotic + Mycobacterium tuberculosis ald mutations confer resistance to cycloserine confers_resistance_to_antibiotic + Mycobacterium tuberculosis alr with mutation conferring resistance to cycloserine confers_resistance_to_antibiotic + Mycobacterium tuberculosis ddlA mutations confer resistance to cycloserine confers_resistance_to_antibiotic |
Publications | Lambert MP and Neuhaus FC. 1972. J Bacteriol 110(3): 978-987. Mechanism of D-cycloserine action: alanine racemase from Escherichia coli W. (PMID 4555420) NEUHAUS FC and LYNCH JL. 1962. Biochem Biophys Res Commun 8: 377-382. Studies on the inhibition of D-alanyl-D-alanine synthetase by the antibiotic D-cycloserine. (PMID 14479178) |
Curator | Description | Most Recent Edit |
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