Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide

Download Sequences

Accession	ARO:3004978
Synonym(s)	Rv2940c
CARD Short Name	Mtub_mas_PZA
Definition	Mutations in mas that can contribute to or confer resistance to pyrazinamide.
AMR Gene Family	pyrazinamide resistant mas
Drug Class	pyrazine antibiotic
Resistance Mechanism	antibiotic target alteration
Classification	9 ontology terms \| Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic resistant gene variant or mutant + pyrazine antibiotic [Drug Class] + antibiotic resistant mas
Parent Term(s)	2 ontology terms \| Show + confers_resistance_to_antibiotic pyrazinamide [Antibiotic] + pyrazinamide resistant mas [AMR Gene Family]
Publications	Gopal P, et al. 2016. ACS Infect Dis 2(9):616-626 Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor Synthesis. (PMID 27759369) Ezewudo M, et al. 2018. Sci Rep 8(1):15382 Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. (PMID 30337678)

Resistomes

Prevalence of Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model

Species	NCBI Chromosome	NCBI Plasmid	NCBI WGS	NCBI GI	GRDI-AMR2
No prevalence data

Detection Models

protein variant model

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 4180

PubMed: mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). CRyPTIC: mutation data acquired from the CRyPTIC catalog, evaluated as resistant (R), susceptible (S), or undetermined (U). ReSeqTB: mutation data acquired from the ReSeqTB catalog, evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. WHO: mutation data acquired from the WHO 2023 catalog, evaluated as resistant (R), susceptible (S), or undetermined (U).

Mutation	Mutation type	PubMed	ReSeqTB	CRyPTIC	WHO
L98M	single resistance variant	no data	ReSeqTB-Minimal	no data	no data
S213C	single resistance variant	no data	ReSeqTB-High	no data	no data
P398R	single resistance variant	no data	ReSeqTB-High	no data	no data
P495R	single resistance variant	no data	ReSeqTB-High	no data	no data
T2005P	single resistance variant	no data	ReSeqTB-Minimal	no data	no data

Protein
DNA

>gb|NP_217456.1|-|Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide [Mycobacterium tuberculosis H37Rv] MESRVTPVAVIGMGCRLPGGINSPDKLWESLLRGDDLVTEIPPDRWDADDYYDPEPGVPGRSVSRWGGFLDDVAGFDAEFFGISEREATSIDPQQRLLLETSWEAIEHAGLDPASLAGSSTAVFTGLTHEDYLVLTTTAGGLASPYVVTGLNNSVASGRIAHTLGLHGPAMTFDTACSSGLMAVHLACRSLHDGEADLALAGGCAVLLEPHASVAASAQGMLSSTGRCHSFDADADGFVRSEGCAMVLLKRLPDALRDGNRIFAVVRGTATNQDGRTETLTMPSEDAQVAVYRAALAAAGVQPETVGVVEAHGTGTPIGDPIEYRSLARVYGAGTPCALGSAKSNMGHSTASAGTVGLIKAILSLRHGVVPPLLHFNRLPDELSDVETGLFVPQAVTPWPNGNDHTPKRVAVSSFGMSGTNVHAIVEEAPAEASAPESSPGDAEVGPRLFMLSSTSSDALRQTARQLATWVEEHQDCVAASDLAYTLARGRAHRPVRTAVVAANLPELVEGLREVADGDALYDAAVGHGDRGPVWVFSGQGSQWAAMGTQLLASEPVFAATIAKLEPVIAAESGFSVTEAITAQQTVTGIDKVQPAVFAVQVALAATMEQTYGVRPGAVVGHSMGESAAAVVAGALSLEDAARVICRRSKLMTRIAGAGAMGSVELPAKQVNSELMARGIDDVVVSVVASPQSTVIGGTSDTVRDLIARWEQRDVMAREVAVDVASHSPQVDPILDDLAAALADIAPMTPKVPYYSATLFDPREQPVCDGAYWVDNLRNTVQFAAAVQAAMEDGYRVFAELSPHPLLTHAVEQTGRSLDMSVAALAGMRREQPLPHGLRGLLTELHRAGAALDYSALYPAGRLVDAPLPAWTHARLFIDDDGQEQRAQGACTITVHPLLGSHVRLTEEPERHVWQGDVGTSVLSWLSDHQVHNVAALPGAAYCEMALAAAAEVFGEAAEVRDITFEQMLLLDEQTPIDAVASIDAPGVVNFTVETNRDGETTRHATAALRAAEDDCPPPGYDITALLQAHPHAVNGTAMRESFAERGVTLGAAFGGLTTAHTAEAGAATVLAEVALPASIRFQQGAYRIHPALLDACFQSVGAGVQAGTATGGLLLPLGVRSLRAYGPTRNARYCYTRLTKAFNDGTRGGEADLDVLDEHGTVLLAVRGLRMGTGTSERDERDRLVSERLLTLGWQQRALPEVGDGEAGSWLLIDTSNAVDTPDMLASTLTDALKSHGPQGTECASLSWSVQDTPPNDQAGLEKLGSQLRGRDGVVIVYGPRVGDPDEHSLLAGREQVRHLVRITRELAEFEGELPRLFVVTRQAQIVKPHDSGERANLEQAGLRGLLRVISSEHPMLRTTLIDVDEHTDVERVAQQLLSGSEEDETAWRNGDWYVARLTPSPLGHEERRTAVLDPDHDGMRVQVRRPGDLQTLEFVASDRVPPGPGQIEVAVSMSSINFADVLIAFGRFPIIDDREPQLGMDFVGVVTAVGEGVTGHQVGDRVGGFSEGGCWRTFLTCDANLAVTLPPGLTDEQAITAATAHATAWYGLNDLAQIKAGDKVLIHSATGGVGQAAISIARAKGAEIFATAGNPAKRAMLRDMGVEHVYDSRSVEFAEQIRRDTDGYGVDIVLNSLTGAAQRAGLELLAFGGRFVEIGKADVYGNTRLGLFPFRRGLTFYYLDLALMSVTQPDRVRELLATVFKLTADGVLTAPQCTHYPLAEAADAIRAMSNAEHTGKLVLDVPRSGRRSVAVTPEQAPLYRRDGSYIITGGLGGLGLFFASKLAAAGCGRIVLTARSQPNPKARQTIEGLRAAGADIVVECGNIAEPDTADRLVSAATATGLPLRGVLHSAAVVEDATLTNITDELIDRDWSPKVFGSWNLHRATLGQPLDWFCLFSSGAALLGSPGQGAYAAANSWVDVFAHWRRAQGLPVSAIAWGAWGEVGRATFLAEGGEIMITPEEGAYAFETLVRHDRAYSGYIPILGAPWLADLVRRSPWGEMFASTGQRSRGPSKFRMELLSLPQDEWAGRLRRLLVEQASVILRRTIDADRSFIEYGLDSLGMLEMRTHVETETGIRLTPKVIATNNTARALAQYLADTLAEEQAAAPAAS

>gb|NP_217456.1|-|Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide [Mycobacterium tuberculosis H37Rv]
MESRVTPVAVIGMGCRLPGGINSPDKLWESLLRGDDLVTEIPPDRWDADDYYDPEPGVPG
RSVSRWGGFLDDVAGFDAEFFGISEREATSIDPQQRLLLETSWEAIEHAGLDPASLAGSS
TAVFTGLTHEDYLVLTTTAGGLASPYVVTGLNNSVASGRIAHTLGLHGPAMTFDTACSSG
LMAVHLACRSLHDGEADLALAGGCAVLLEPHASVAASAQGMLSSTGRCHSFDADADGFVR
SEGCAMVLLKRLPDALRDGNRIFAVVRGTATNQDGRTETLTMPSEDAQVAVYRAALAAAG
VQPETVGVVEAHGTGTPIGDPIEYRSLARVYGAGTPCALGSAKSNMGHSTASAGTVGLIK
AILSLRHGVVPPLLHFNRLPDELSDVETGLFVPQAVTPWPNGNDHTPKRVAVSSFGMSGT
NVHAIVEEAPAEASAPESSPGDAEVGPRLFMLSSTSSDALRQTARQLATWVEEHQDCVAA
SDLAYTLARGRAHRPVRTAVVAANLPELVEGLREVADGDALYDAAVGHGDRGPVWVFSGQ
GSQWAAMGTQLLASEPVFAATIAKLEPVIAAESGFSVTEAITAQQTVTGIDKVQPAVFAV
QVALAATMEQTYGVRPGAVVGHSMGESAAAVVAGALSLEDAARVICRRSKLMTRIAGAGA
MGSVELPAKQVNSELMARGIDDVVVSVVASPQSTVIGGTSDTVRDLIARWEQRDVMAREV
AVDVASHSPQVDPILDDLAAALADIAPMTPKVPYYSATLFDPREQPVCDGAYWVDNLRNT
VQFAAAVQAAMEDGYRVFAELSPHPLLTHAVEQTGRSLDMSVAALAGMRREQPLPHGLRG
LLTELHRAGAALDYSALYPAGRLVDAPLPAWTHARLFIDDDGQEQRAQGACTITVHPLLG
SHVRLTEEPERHVWQGDVGTSVLSWLSDHQVHNVAALPGAAYCEMALAAAAEVFGEAAEV
RDITFEQMLLLDEQTPIDAVASIDAPGVVNFTVETNRDGETTRHATAALRAAEDDCPPPG
YDITALLQAHPHAVNGTAMRESFAERGVTLGAAFGGLTTAHTAEAGAATVLAEVALPASI
RFQQGAYRIHPALLDACFQSVGAGVQAGTATGGLLLPLGVRSLRAYGPTRNARYCYTRLT
KAFNDGTRGGEADLDVLDEHGTVLLAVRGLRMGTGTSERDERDRLVSERLLTLGWQQRAL
PEVGDGEAGSWLLIDTSNAVDTPDMLASTLTDALKSHGPQGTECASLSWSVQDTPPNDQA
GLEKLGSQLRGRDGVVIVYGPRVGDPDEHSLLAGREQVRHLVRITRELAEFEGELPRLFV
VTRQAQIVKPHDSGERANLEQAGLRGLLRVISSEHPMLRTTLIDVDEHTDVERVAQQLLS
GSEEDETAWRNGDWYVARLTPSPLGHEERRTAVLDPDHDGMRVQVRRPGDLQTLEFVASD
RVPPGPGQIEVAVSMSSINFADVLIAFGRFPIIDDREPQLGMDFVGVVTAVGEGVTGHQV
GDRVGGFSEGGCWRTFLTCDANLAVTLPPGLTDEQAITAATAHATAWYGLNDLAQIKAGD
KVLIHSATGGVGQAAISIARAKGAEIFATAGNPAKRAMLRDMGVEHVYDSRSVEFAEQIR
RDTDGYGVDIVLNSLTGAAQRAGLELLAFGGRFVEIGKADVYGNTRLGLFPFRRGLTFYY
LDLALMSVTQPDRVRELLATVFKLTADGVLTAPQCTHYPLAEAADAIRAMSNAEHTGKLV
LDVPRSGRRSVAVTPEQAPLYRRDGSYIITGGLGGLGLFFASKLAAAGCGRIVLTARSQP
NPKARQTIEGLRAAGADIVVECGNIAEPDTADRLVSAATATGLPLRGVLHSAAVVEDATL
TNITDELIDRDWSPKVFGSWNLHRATLGQPLDWFCLFSSGAALLGSPGQGAYAAANSWVD
VFAHWRRAQGLPVSAIAWGAWGEVGRATFLAEGGEIMITPEEGAYAFETLVRHDRAYSGY
IPILGAPWLADLVRRSPWGEMFASTGQRSRGPSKFRMELLSLPQDEWAGRLRRLLVEQAS
VILRRTIDADRSFIEYGLDSLGMLEMRTHVETETGIRLTPKVIATNNTARALAQYLADTL
AEEQAAAPAAS

>gb|NC_000962.3|-|3276380-3282715|Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide [Mycobacterium tuberculosis H37Rv]
ATGGAATCACGTGTCACTCCCGTTGCGGTGATCGGGATGGGATGTCGGCTTCCTGGGGGGATCAACTCGCCCGACAAACTGTGGGAGTCG
TTGCTGCGCGGTGATGACTTGGTCACCGAGATTCCGCCCGACCGCTGGGACGCCGACGACTATTACGACCCTGAGCCAGGGGTTCCCGGG
CGGTCGGTGTCCCGGTGGGGTGGGTTCCTTGACGACGTCGCCGGTTTCGATGCTGAGTTCTTCGGGATTAGCGAGCGGGAAGCGACCTCG
ATCGATCCGCAGCAGCGGCTACTGCTGGAAACGTCGTGGGAGGCGATCGAGCATGCTGGTCTGGATCCGGCGTCGTTGGCCGGGTCCTCG
ACGGCCGTTTTTACTGGGCTGACCCACGAGGACTACCTGGTACTCACCACAACGGCGGGCGGTTTGGCCAGTCCATATGTGGTTACCGGC
CTCAACAACAGTGTGGCGTCAGGGCGGATCGCGCACACATTGGGTCTACATGGTCCGGCGATGACGTTTGACACCGCGTGTTCTTCGGGT
CTGATGGCGGTGCACCTGGCCTGCCGCAGCCTGCATGACGGCGAAGCTGACCTCGCTTTGGCGGGCGGTTGTGCGGTGCTGCTGGAGCCG
CATGCCAGTGTGGCGGCGTCTGCGCAGGGCATGCTGTCGTCAACCGGTCGGTGCCATTCATTCGATGCTGACGCGGATGGGTTTGTGCGT
TCCGAGGGCTGCGCGATGGTGTTGCTGAAGCGACTGCCGGATGCGCTGCGCGACGGTAATCGGATCTTCGCCGTGGTGCGTGGCACGGCC
ACCAATCAGGACGGCCGCACGGAGACGCTCACCATGCCGTCCGAGGACGCCCAGGTTGCCGTGTACCGTGCGGCGTTGGCGGCGGCGGGC
GTGCAGCCCGAAACGGTCGGTGTGGTCGAGGCGCACGGCACCGGTACGCCAATCGGCGACCCGATTGAGTACCGCAGCCTGGCGCGGGTG
TATGGCGCGGGCACCCCCTGCGCGCTTGGATCGGCCAAGAGCAACATGGGGCACAGCACGGCATCGGCGGGGACCGTCGGGCTGATCAAG
GCAATTCTGTCACTGCGGCACGGGGTGGTGCCGCCGCTGCTGCATTTCAATCGGCTGCCCGATGAGCTTTCCGACGTCGAGACCGGGCTC
TTTGTGCCGCAAGCGGTTACGCCGTGGCCCAACGGTAATGATCACACACCGAAGCGGGTCGCGGTGTCCTCGTTCGGGATGTCCGGGACC
AACGTGCATGCCATCGTGGAAGAGGCCCCAGCAGAAGCTTCCGCACCCGAGAGTTCACCGGGCGACGCTGAGGTGGGCCCGCGGCTATTC
ATGCTGTCGTCCACGTCCAGCGACGCACTGCGCCAGACGGCCCGCCAACTAGCCACCTGGGTGGAAGAACACCAGGACTGCGTGGCGGCC
TCGGATCTGGCCTACACGCTGGCGCGTGGCCGCGCGCACCGGCCGGTGCGCACCGCGGTGGTTGCCGCCAACCTGCCGGAGCTCGTCGAG
GGTTTGCGCGAGGTGGCCGACGGTGACGCCCTCTATGACGCGGCGGTGGGACACGGTGATCGAGGACCGGTCTGGGTCTTCTCCGGGCAA
GGGTCGCAGTGGGCGGCGATGGGCACGCAATTGCTCGCCAGCGAACCAGTGTTCGCGGCCACCATCGCCAAGCTGGAGCCGGTGATCGCC
GCAGAATCGGGATTCTCGGTGACCGAGGCGATAACGGCGCAGCAGACCGTGACCGGAATCGACAAAGTGCAGCCGGCAGTGTTCGCCGTT
CAGGTCGCGTTGGCCGCCACCATGGAGCAAACCTACGGAGTGCGGCCGGGCGCGGTCGTCGGACACTCGATGGGTGAGTCGGCCGCGGCC
GTCGTCGCGGGGGCACTGTCGCTCGAGGACGCGGCGCGCGTCATTTGCCGCCGCTCGAAGCTGATGACCCGCATAGCCGGTGCTGGTGCC
ATGGGCTCGGTGGAATTGCCCGCCAAGCAAGTGAATTCGGAGCTGATGGCACGCGGAATCGACGATGTTGTGGTCTCGGTGGTGGCGTCC
CCGCAATCCACGGTGATCGGCGGTACGAGCGACACCGTTCGTGACCTCATCGCCCGTTGGGAGCAGCGGGACGTGATGGCGCGCGAGGTG
GCCGTCGACGTGGCGTCGCACTCGCCTCAAGTCGATCCGATACTCGACGATTTGGCCGCGGCGCTGGCGGACATTGCTCCGATGACGCCC
AAGGTGCCGTACTACTCGGCGACCCTGTTCGACCCGCGCGAGCAGCCGGTGTGCGATGGCGCTTACTGGGTGGACAATCTGCGCAACACG
GTGCAGTTCGCCGCGGCGGTGCAGGCTGCGATGGAGGACGGCTACCGGGTCTTCGCGGAGCTGTCGCCCCACCCGCTGCTTACCCACGCC
GTCGAACAGACGGGCCGAAGCCTCGACATGTCGGTCGCCGCCCTGGCCGGCATGCGGCGAGAGCAGCCTCTGCCGCATGGTCTGCGCGGC
TTGCTGACGGAGCTGCACCGCGCGGGCGCCGCTTTGGACTATTCGGCGCTGTATCCCGCTGGGCGGCTGGTGGATGCGCCGCTGCCGGCG
TGGACCCACGCCCGCCTATTCATCGACGATGATGGGCAAGAACAGCGGGCACAAGGTGCCTGCACCATCACCGTGCATCCGTTGCTTGGC
TCGCATGTGCGGCTGACTGAGGAACCTGAGCGCCACGTCTGGCAGGGCGACGTTGGCACCTCGGTGCTGTCCTGGCTCAGCGATCATCAG
GTGCATAACGTTGCCGCCCTTCCCGGCGCCGCCTACTGCGAGATGGCTTTGGCTGCGGCCGCTGAGGTCTTCGGCGAAGCGGCTGAGGTT
CGCGACATCACCTTTGAGCAGATGTTGTTGCTCGACGAGCAGACCCCGATCGACGCCGTCGCATCGATCGACGCGCCTGGTGTCGTCAAC
TTCACCGTGGAGACCAACCGGGACGGTGAAACCACCCGGCATGCCACCGCGGCGCTGCGCGCCGCCGAAGATGACTGCCCGCCGCCGGGG
TACGACATCACCGCTCTGCTGCAGGCGCATCCGCACGCCGTGAACGGGACCGCCATGCGGGAATCGTTCGCCGAGCGTGGTGTTACTTTG
GGCGCCGCGTTCGGTGGTCTGACCACCGCGCATACCGCCGAGGCGGGAGCCGCGACGGTGCTGGCCGAGGTCGCGCTGCCCGCGTCGATC
CGGTTCCAGCAGGGCGCCTACCGAATCCACCCGGCGCTGCTGGACGCTTGTTTCCAGTCGGTCGGCGCGGGCGTCCAGGCCGGTACGGCC
ACTGGTGGCCTGCTGTTGCCGTTGGGTGTGCGCAGCCTGCGTGCCTACGGGCCTACCCGCAATGCCCGCTACTGCTACACGCGGTTGACC
AAGGCCTTCAACGACGGGACCCGAGGTGGTGAGGCCGACCTCGACGTGCTGGACGAGCACGGGACCGTCCTGTTGGCCGTGCGTGGGCTA
CGCATGGGAACCGGGACCTCCGAACGCGACGAGCGTGACCGCCTAGTCAGCGAGCGGCTACTGACCCTCGGATGGCAGCAGCGAGCGCTG
CCCGAGGTTGGCGACGGCGAGGCTGGATCGTGGCTATTGATCGACACTTCCAACGCCGTCGACACCCCCGACATGTTGGCTTCCACGTTG
ACGGACGCGCTGAAGTCCCACGGCCCCCAAGGCACCGAATGCGCCAGCCTGTCCTGGTCGGTCCAGGACACCCCGCCCAACGATCAAGCT
GGCCTCGAAAAGCTGGGCAGCCAGCTGCGTGGCCGCGATGGTGTGGTGATCGTGTATGGGCCTCGCGTCGGCGACCCCGATGAGCACAGT
CTGCTGGCCGGTCGTGAACAGGTCCGTCACCTGGTTCGGATCACCCGGGAACTGGCTGAATTCGAGGGCGAGCTGCCGCGCTTGTTCGTG
GTGACCAGACAAGCCCAGATAGTGAAGCCGCACGACTCGGGAGAAAGAGCCAACCTGGAGCAGGCCGGCCTGCGTGGTCTGCTACGGGTG
ATCAGCAGTGAACATCCGATGCTGCGCACCACCTTGATCGATGTGGACGAACACACGGACGTTGAGCGGGTGGCCCAGCAGCTGCTGAGC
GGATCGGAAGAGGACGAGACGGCCTGGCGGAATGGCGACTGGTATGTGGCCCGCTTGACCCCCAGTCCGCTGGGCCATGAAGAGCGGCGC
ACCGCGGTCTTGGATCCCGACCACGACGGTATGCGGGTGCAGGTCCGCAGGCCGGGAGACTTGCAAACGTTGGAATTCGTTGCGAGTGAC
CGAGTTCCGCCCGGCCCCGGGCAAATCGAAGTCGCGGTCAGCATGTCCAGCATCAACTTCGCCGACGTTTTGATCGCGTTTGGACGATTC
CCCATTATCGATGACCGCGAGCCGCAGTTGGGTATGGATTTCGTCGGTGTGGTGACTGCGGTCGGGGAAGGTGTCACCGGTCACCAGGTC
GGTGATCGTGTTGGCGGTTTCTCCGAAGGTGGCTGTTGGCGGACGTTCCTCACCTGTGACGCCAACCTCGCGGTCACGCTGCCGCCCGGC
TTGACCGATGAGCAGGCGATCACGGCGGCCACCGCGCATGCCACCGCCTGGTATGGGCTCAACGACCTGGCTCAGATCAAGGCCGGTGAC
AAAGTGTTGATTCACTCCGCCACCGGCGGTGTGGGGCAGGCGGCCATATCGATTGCCCGCGCCAAGGGAGCGGAGATTTTCGCGACCGCC
GGCAATCCCGCGAAGCGAGCCATGCTGCGCGACATGGGCGTCGAGCATGTCTACGATTCGCGCAGCGTCGAGTTCGCCGAGCAGATCCGG
CGCGACACCGACGGGTACGGCGTGGATATCGTGCTGAACTCGCTGACCGGCGCCGCCCAACGTGCGGGGCTGGAGTTGTTGGCCTTCGGC
GGACGCTTCGTCGAAATCGGCAAGGCCGACGTTTACGGCAACACCCGGCTGGGGCTGTTCCCGTTCCGTCGCGGACTGACCTTCTACTAC
TTGGACCTCGCGCTGATGTCGGTCACCCAGCCCGACCGGGTCCGTGAGTTGCTGGCCACGGTGTTCAAGCTCACCGCAGACGGGGTGCTG
ACCGCACCGCAATGCACTCATTACCCGTTGGCCGAGGCGGCCGACGCCATCCGGGCAATGAGCAACGCCGAGCACACCGGCAAACTCGTG
CTCGACGTACCGCGTAGCGGCCGTAGAAGCGTGGCGGTCACCCCGGAGCAAGCTCCGCTGTACCGCCGCGACGGCTCCTACATCATCACC
GGCGGCCTGGGTGGCCTCGGCCTGTTCTTCGCCTCGAAGCTGGCCGCGGCGGGCTGTGGCCGGATCGTGCTGACCGCACGTTCCCAGCCC
AACCCCAAAGCGCGGCAGACCATCGAAGGCCTGCGCGCGGCTGGGGCCGACATCGTGGTGGAGTGTGGCAACATCGCCGAACCCGACACG
GCGGACCGGCTGGTGAGTGCGGCGACCGCTACCGGGCTTCCGCTGCGCGGTGTGCTGCACTCGGCGGCGGTGGTCGAGGATGCCACGCTG
ACCAACATCACCGATGAGCTCATCGATCGCGACTGGTCGCCCAAGGTGTTCGGATCCTGGAACCTACACCGCGCCACCCTCGGTCAGCCG
CTGGACTGGTTCTGCTTGTTCTCCTCGGGAGCGGCATTGCTCGGCTCGCCGGGTCAGGGCGCCTACGCGGCGGCCAACAGCTGGGTCGAC
GTCTTCGCGCACTGGCGCCGCGCCCAGGGCCTGCCGGTCAGCGCGATTGCGTGGGGTGCGTGGGGCGAGGTCGGCCGCGCCACGTTCTTG
GCCGAGGGGGGCGAAATCATGATCACCCCGGAGGAAGGTGCGTATGCCTTCGAGACGCTCGTGCGCCACGACCGCGCCTACAGCGGTTAC
ATTCCGATCCTCGGGGCGCCATGGCTGGCCGACCTTGTCCGACGCAGCCCGTGGGGTGAAATGTTCGCATCCACTGGGCAGCGGTCAAGG
GGCCCAAGCAAATTCCGCATGGAGCTCCTTTCGCTGCCGCAAGATGAATGGGCCGGCCGGCTACGGCGTCTGCTGGTTGAGCAGGCCAGT
GTGATCCTGCGTCGCACGATCGACGCTGACCGCTCATTCATCGAGTACGGCCTGGATTCGCTGGGCATGCTCGAGATGCGTACCCACGTT
GAAACCGAGACCGGGATACGCCTGACCCCCAAGGTCATCGCCACAAACAACACCGCCCGCGCTTTGGCCCAGTACTTGGCGGACACGCTG
GCCGAGGAGCAGGCGGCGGCACCGGCGGCATCATAG

>gb|NC_000962.3|-|3276380-3282715|Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide [Mycobacterium tuberculosis H37Rv] ATGGAATCACGTGTCACTCCCGTTGCGGTGATCGGGATGGGATGTCGGCTTCCTGGGGGGATCAACTCGCCCGACAAACTGTGGGAGTCGTTGCTGCGCGGTGATGACTTGGTCACCGAGATTCCGCCCGACCGCTGGGACGCCGACGACTATTACGACCCTGAGCCAGGGGTTCCCGGGCGGTCGGTGTCCCGGTGGGGTGGGTTCCTTGACGACGTCGCCGGTTTCGATGCTGAGTTCTTCGGGATTAGCGAGCGGGAAGCGACCTCGATCGATCCGCAGCAGCGGCTACTGCTGGAAACGTCGTGGGAGGCGATCGAGCATGCTGGTCTGGATCCGGCGTCGTTGGCCGGGTCCTCGACGGCCGTTTTTACTGGGCTGACCCACGAGGACTACCTGGTACTCACCACAACGGCGGGCGGTTTGGCCAGTCCATATGTGGTTACCGGCCTCAACAACAGTGTGGCGTCAGGGCGGATCGCGCACACATTGGGTCTACATGGTCCGGCGATGACGTTTGACACCGCGTGTTCTTCGGGTCTGATGGCGGTGCACCTGGCCTGCCGCAGCCTGCATGACGGCGAAGCTGACCTCGCTTTGGCGGGCGGTTGTGCGGTGCTGCTGGAGCCGCATGCCAGTGTGGCGGCGTCTGCGCAGGGCATGCTGTCGTCAACCGGTCGGTGCCATTCATTCGATGCTGACGCGGATGGGTTTGTGCGTTCCGAGGGCTGCGCGATGGTGTTGCTGAAGCGACTGCCGGATGCGCTGCGCGACGGTAATCGGATCTTCGCCGTGGTGCGTGGCACGGCCACCAATCAGGACGGCCGCACGGAGACGCTCACCATGCCGTCCGAGGACGCCCAGGTTGCCGTGTACCGTGCGGCGTTGGCGGCGGCGGGCGTGCAGCCCGAAACGGTCGGTGTGGTCGAGGCGCACGGCACCGGTACGCCAATCGGCGACCCGATTGAGTACCGCAGCCTGGCGCGGGTGTATGGCGCGGGCACCCCCTGCGCGCTTGGATCGGCCAAGAGCAACATGGGGCACAGCACGGCATCGGCGGGGACCGTCGGGCTGATCAAGGCAATTCTGTCACTGCGGCACGGGGTGGTGCCGCCGCTGCTGCATTTCAATCGGCTGCCCGATGAGCTTTCCGACGTCGAGACCGGGCTCTTTGTGCCGCAAGCGGTTACGCCGTGGCCCAACGGTAATGATCACACACCGAAGCGGGTCGCGGTGTCCTCGTTCGGGATGTCCGGGACCAACGTGCATGCCATCGTGGAAGAGGCCCCAGCAGAAGCTTCCGCACCCGAGAGTTCACCGGGCGACGCTGAGGTGGGCCCGCGGCTATTCATGCTGTCGTCCACGTCCAGCGACGCACTGCGCCAGACGGCCCGCCAACTAGCCACCTGGGTGGAAGAACACCAGGACTGCGTGGCGGCCTCGGATCTGGCCTACACGCTGGCGCGTGGCCGCGCGCACCGGCCGGTGCGCACCGCGGTGGTTGCCGCCAACCTGCCGGAGCTCGTCGAGGGTTTGCGCGAGGTGGCCGACGGTGACGCCCTCTATGACGCGGCGGTGGGACACGGTGATCGAGGACCGGTCTGGGTCTTCTCCGGGCAAGGGTCGCAGTGGGCGGCGATGGGCACGCAATTGCTCGCCAGCGAACCAGTGTTCGCGGCCACCATCGCCAAGCTGGAGCCGGTGATCGCCGCAGAATCGGGATTCTCGGTGACCGAGGCGATAACGGCGCAGCAGACCGTGACCGGAATCGACAAAGTGCAGCCGGCAGTGTTCGCCGTTCAGGTCGCGTTGGCCGCCACCATGGAGCAAACCTACGGAGTGCGGCCGGGCGCGGTCGTCGGACACTCGATGGGTGAGTCGGCCGCGGCCGTCGTCGCGGGGGCACTGTCGCTCGAGGACGCGGCGCGCGTCATTTGCCGCCGCTCGAAGCTGATGACCCGCATAGCCGGTGCTGGTGCCATGGGCTCGGTGGAATTGCCCGCCAAGCAAGTGAATTCGGAGCTGATGGCACGCGGAATCGACGATGTTGTGGTCTCGGTGGTGGCGTCCCCGCAATCCACGGTGATCGGCGGTACGAGCGACACCGTTCGTGACCTCATCGCCCGTTGGGAGCAGCGGGACGTGATGGCGCGCGAGGTGGCCGTCGACGTGGCGTCGCACTCGCCTCAAGTCGATCCGATACTCGACGATTTGGCCGCGGCGCTGGCGGACATTGCTCCGATGACGCCCAAGGTGCCGTACTACTCGGCGACCCTGTTCGACCCGCGCGAGCAGCCGGTGTGCGATGGCGCTTACTGGGTGGACAATCTGCGCAACACGGTGCAGTTCGCCGCGGCGGTGCAGGCTGCGATGGAGGACGGCTACCGGGTCTTCGCGGAGCTGTCGCCCCACCCGCTGCTTACCCACGCCGTCGAACAGACGGGCCGAAGCCTCGACATGTCGGTCGCCGCCCTGGCCGGCATGCGGCGAGAGCAGCCTCTGCCGCATGGTCTGCGCGGCTTGCTGACGGAGCTGCACCGCGCGGGCGCCGCTTTGGACTATTCGGCGCTGTATCCCGCTGGGCGGCTGGTGGATGCGCCGCTGCCGGCGTGGACCCACGCCCGCCTATTCATCGACGATGATGGGCAAGAACAGCGGGCACAAGGTGCCTGCACCATCACCGTGCATCCGTTGCTTGGCTCGCATGTGCGGCTGACTGAGGAACCTGAGCGCCACGTCTGGCAGGGCGACGTTGGCACCTCGGTGCTGTCCTGGCTCAGCGATCATCAGGTGCATAACGTTGCCGCCCTTCCCGGCGCCGCCTACTGCGAGATGGCTTTGGCTGCGGCCGCTGAGGTCTTCGGCGAAGCGGCTGAGGTTCGCGACATCACCTTTGAGCAGATGTTGTTGCTCGACGAGCAGACCCCGATCGACGCCGTCGCATCGATCGACGCGCCTGGTGTCGTCAACTTCACCGTGGAGACCAACCGGGACGGTGAAACCACCCGGCATGCCACCGCGGCGCTGCGCGCCGCCGAAGATGACTGCCCGCCGCCGGGGTACGACATCACCGCTCTGCTGCAGGCGCATCCGCACGCCGTGAACGGGACCGCCATGCGGGAATCGTTCGCCGAGCGTGGTGTTACTTTGGGCGCCGCGTTCGGTGGTCTGACCACCGCGCATACCGCCGAGGCGGGAGCCGCGACGGTGCTGGCCGAGGTCGCGCTGCCCGCGTCGATCCGGTTCCAGCAGGGCGCCTACCGAATCCACCCGGCGCTGCTGGACGCTTGTTTCCAGTCGGTCGGCGCGGGCGTCCAGGCCGGTACGGCCACTGGTGGCCTGCTGTTGCCGTTGGGTGTGCGCAGCCTGCGTGCCTACGGGCCTACCCGCAATGCCCGCTACTGCTACACGCGGTTGACCAAGGCCTTCAACGACGGGACCCGAGGTGGTGAGGCCGACCTCGACGTGCTGGACGAGCACGGGACCGTCCTGTTGGCCGTGCGTGGGCTACGCATGGGAACCGGGACCTCCGAACGCGACGAGCGTGACCGCCTAGTCAGCGAGCGGCTACTGACCCTCGGATGGCAGCAGCGAGCGCTGCCCGAGGTTGGCGACGGCGAGGCTGGATCGTGGCTATTGATCGACACTTCCAACGCCGTCGACACCCCCGACATGTTGGCTTCCACGTTGACGGACGCGCTGAAGTCCCACGGCCCCCAAGGCACCGAATGCGCCAGCCTGTCCTGGTCGGTCCAGGACACCCCGCCCAACGATCAAGCTGGCCTCGAAAAGCTGGGCAGCCAGCTGCGTGGCCGCGATGGTGTGGTGATCGTGTATGGGCCTCGCGTCGGCGACCCCGATGAGCACAGTCTGCTGGCCGGTCGTGAACAGGTCCGTCACCTGGTTCGGATCACCCGGGAACTGGCTGAATTCGAGGGCGAGCTGCCGCGCTTGTTCGTGGTGACCAGACAAGCCCAGATAGTGAAGCCGCACGACTCGGGAGAAAGAGCCAACCTGGAGCAGGCCGGCCTGCGTGGTCTGCTACGGGTGATCAGCAGTGAACATCCGATGCTGCGCACCACCTTGATCGATGTGGACGAACACACGGACGTTGAGCGGGTGGCCCAGCAGCTGCTGAGCGGATCGGAAGAGGACGAGACGGCCTGGCGGAATGGCGACTGGTATGTGGCCCGCTTGACCCCCAGTCCGCTGGGCCATGAAGAGCGGCGCACCGCGGTCTTGGATCCCGACCACGACGGTATGCGGGTGCAGGTCCGCAGGCCGGGAGACTTGCAAACGTTGGAATTCGTTGCGAGTGACCGAGTTCCGCCCGGCCCCGGGCAAATCGAAGTCGCGGTCAGCATGTCCAGCATCAACTTCGCCGACGTTTTGATCGCGTTTGGACGATTCCCCATTATCGATGACCGCGAGCCGCAGTTGGGTATGGATTTCGTCGGTGTGGTGACTGCGGTCGGGGAAGGTGTCACCGGTCACCAGGTCGGTGATCGTGTTGGCGGTTTCTCCGAAGGTGGCTGTTGGCGGACGTTCCTCACCTGTGACGCCAACCTCGCGGTCACGCTGCCGCCCGGCTTGACCGATGAGCAGGCGATCACGGCGGCCACCGCGCATGCCACCGCCTGGTATGGGCTCAACGACCTGGCTCAGATCAAGGCCGGTGACAAAGTGTTGATTCACTCCGCCACCGGCGGTGTGGGGCAGGCGGCCATATCGATTGCCCGCGCCAAGGGAGCGGAGATTTTCGCGACCGCCGGCAATCCCGCGAAGCGAGCCATGCTGCGCGACATGGGCGTCGAGCATGTCTACGATTCGCGCAGCGTCGAGTTCGCCGAGCAGATCCGGCGCGACACCGACGGGTACGGCGTGGATATCGTGCTGAACTCGCTGACCGGCGCCGCCCAACGTGCGGGGCTGGAGTTGTTGGCCTTCGGCGGACGCTTCGTCGAAATCGGCAAGGCCGACGTTTACGGCAACACCCGGCTGGGGCTGTTCCCGTTCCGTCGCGGACTGACCTTCTACTACTTGGACCTCGCGCTGATGTCGGTCACCCAGCCCGACCGGGTCCGTGAGTTGCTGGCCACGGTGTTCAAGCTCACCGCAGACGGGGTGCTGACCGCACCGCAATGCACTCATTACCCGTTGGCCGAGGCGGCCGACGCCATCCGGGCAATGAGCAACGCCGAGCACACCGGCAAACTCGTGCTCGACGTACCGCGTAGCGGCCGTAGAAGCGTGGCGGTCACCCCGGAGCAAGCTCCGCTGTACCGCCGCGACGGCTCCTACATCATCACCGGCGGCCTGGGTGGCCTCGGCCTGTTCTTCGCCTCGAAGCTGGCCGCGGCGGGCTGTGGCCGGATCGTGCTGACCGCACGTTCCCAGCCCAACCCCAAAGCGCGGCAGACCATCGAAGGCCTGCGCGCGGCTGGGGCCGACATCGTGGTGGAGTGTGGCAACATCGCCGAACCCGACACGGCGGACCGGCTGGTGAGTGCGGCGACCGCTACCGGGCTTCCGCTGCGCGGTGTGCTGCACTCGGCGGCGGTGGTCGAGGATGCCACGCTGACCAACATCACCGATGAGCTCATCGATCGCGACTGGTCGCCCAAGGTGTTCGGATCCTGGAACCTACACCGCGCCACCCTCGGTCAGCCGCTGGACTGGTTCTGCTTGTTCTCCTCGGGAGCGGCATTGCTCGGCTCGCCGGGTCAGGGCGCCTACGCGGCGGCCAACAGCTGGGTCGACGTCTTCGCGCACTGGCGCCGCGCCCAGGGCCTGCCGGTCAGCGCGATTGCGTGGGGTGCGTGGGGCGAGGTCGGCCGCGCCACGTTCTTGGCCGAGGGGGGCGAAATCATGATCACCCCGGAGGAAGGTGCGTATGCCTTCGAGACGCTCGTGCGCCACGACCGCGCCTACAGCGGTTACATTCCGATCCTCGGGGCGCCATGGCTGGCCGACCTTGTCCGACGCAGCCCGTGGGGTGAAATGTTCGCATCCACTGGGCAGCGGTCAAGGGGCCCAAGCAAATTCCGCATGGAGCTCCTTTCGCTGCCGCAAGATGAATGGGCCGGCCGGCTACGGCGTCTGCTGGTTGAGCAGGCCAGTGTGATCCTGCGTCGCACGATCGACGCTGACCGCTCATTCATCGAGTACGGCCTGGATTCGCTGGGCATGCTCGAGATGCGTACCCACGTTGAAACCGAGACCGGGATACGCCTGACCCCCAAGGTCATCGCCACAAACAACACCGCCCGCGCTTTGGCCCAGTACTTGGCGGACACGCTGGCCGAGGAGCAGGCGGCGGCACCGGCGGCATCATAG

Curator Acknowledgements

Curator	Description	Most Recent Edit

Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide

Prevalence: protein variant model

Graph