Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3003413 |
Definition | Pyrazinamide is an antimycobacterial. It is highly specific and active only against Mycobacterium tuberculosis. This compound is a prodrug and needs to be activated inside the cell. It interferes with the bacterium's ability to synthesize new fatty acids, causing cell death. |
SMILES | NC(=O)c1cnccn1 |
PubChem | 1046 |
CAS | 98-96-4 |
ChEMBL | CHEMBL614 |
Drug Class | pyrazine antibiotic |
Classification | 2 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show + pyrazine antibiotic [Drug Class] |
Sub-Term(s) | 12 ontology terms | Show + Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide confers_resistance_to_antibiotic + Mycobacterium tuberculosis Rv1258c mutations confer resistance to pyrazinamide, isoniazid, and streptomycin confers_resistance_to_antibiotic + Mycobacterium tuberculosis Rv0191 mutations confer resistance to pyrazinamide confers_resistance_to_antibiotic + Mycobacterium tuberculosis Rv1667 mutations confer resistance to pyrazinamide confers_resistance_to_antibiotic + Mycobacterium tuberculosis Rv2731 mutations confer resistance to pyrazinamide confers_resistance_to_antibiotic + Mycobacterium tuberculosis Rv3169 mutations confer resistance to pyrazinamide confers_resistance_to_antibiotic + Mycobacterium tuberculosis clpC1 with mutation conferring resistance to pyrazinamide confers_resistance_to_antibiotic + Mycobacterium tuberculosis gpsI with mutations conferring resistance to pyrazinamide confers_resistance_to_antibiotic + Mycobacterium tuberculosis mas mutations confer resistance to pyrazinamide confers_resistance_to_antibiotic + Mycobacterium tuberculosis ppsC mutations confer resistance to pyrazinamide confers_resistance_to_antibiotic + Mycobacterium tuberculosis ppsD mutations confer resistance to pyrazinamide confers_resistance_to_antibiotic + Mycobacterium tuberculosis rpsA mutations conferring resistance to pyrazinamide confers_resistance_to_antibiotic |
Publications | Zhang Y, et al. 2014. Microbiol Spectr 2(4):MGM2-0023-2013 Mechanisms of Pyrazinamide Action and Resistance. (PMID 26104205) |
Curator | Description | Most Recent Edit |
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