| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3003394 |
| Synonym(s) | Rv2043c |
| CARD Short Name | Mtub_pncA_PZA |
| Definition | pncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide. Some mutation within pncA are associated with loss of enzyme activity, resulting in pyrazinamide resistance. |
| AMR Gene Family | Pyrazinamide resistant pncA |
| Drug Class | pyrazine antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic resistance gene variant or mutant + pyrazine antibiotic [Drug Class] + antibiotic resistant pncA |
| Parent Term(s) | 2 ontology terms | Show + confers_resistance_to_antibiotic pyrazinamide [Antibiotic] + Pyrazinamide resistant pncA [AMR Gene Family] |
| Resistomes with Sequence Variants | Mycobacterium tuberculosisg+wgs |
| Publications | Campbell PJ, et al. 2011. Antimicrob Agents Chemother 55(5): 2032-2041. Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis. (PMID 21300839) Scorpio A, et al. 1997. Antimicrob Agents Chemother 41(3): 540-543. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis. (PMID 9055989) Lemaitre N, et al. 1999. Antimicrob Agents Chemother 43(7): 1761-1763. Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA. (PMID 10390238) Hirano K, et al. 1998. Tuber Lung Dis 78(2): 117-122. Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis. (PMID 9692180) Cheng SJ, et al. 2000. Antimicrob Agents Chemother 44(3): 528-532. pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada. (PMID 10681313) Hou L, et al. 2000. Epidemiol Infect 124(2): 227-232. Molecular characterization of pncA gene mutations in Mycobacterium tuberculosis clinical isolates from China. (PMID 10813147) Chan RC, et al. 2007. J Antimicrob Chemother 59(5): 866-873. Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong. (PMID 17360809) Stavrum R, et al. 2009. PLoS One 4(2): E4540. In-depth molecular characterization of Mycobacterium tuberculosis from New Delhi--predominance of drug resistant isolates of the 'modern' (TbD1) type. (PMID 19234602) Morlock GP, et al. 2000. Antimicrob Agents Chemother 44(12): 3298-3301. Characterization of spontaneous, In vitro-selected, rifampin-resistant mutants of Mycobacterium tuberculosis strain H37Rv. (PMID 11083630) Marttila HJ, et al. 1999. Antimicrob. Agents Chemother. 43(7):1764-6 pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia. (PMID 10390239) Sreevatsan S, et al. 1997. Antimicrob. Agents Chemother. 41(3):636-40 Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms. (PMID 9056006) Hannan MM, et al. 2001. J. Clin. Microbiol. 39(2):647-50 Pyrazinamide-monoresistant Mycobacterium tuberculosis in the United States. (PMID 11158123) Lee KW, et al. 2001. J. Korean Med. Sci. 16(5):537-43 Characterization of pncA mutations of pyrazinamide-resistant Mycobacterium tuberculosis in Korea. (PMID 11641519) Mestdagh M, et al. 1999. Antimicrob. Agents Chemother. 43(9):2317-9 Relationship between pyrazinamide resistance, loss of pyrazinamidase activity, and mutations in the pncA locus in multidrug-resistant clinical isolates of Mycobacterium tuberculosis. (PMID 10471589) Sekiguchi J, et al. 2007. J. Clin. Microbiol. 45(9):2802-7 Development and evaluation of a line probe assay for rapid identification of pncA mutations in pyrazinamide-resistant mycobacterium tuberculosis strains. (PMID 17596354) Miotto P, et al. 2014. MBio 5(5):e01819-14 Mycobacterium tuberculosis pyrazinamide resistance determinants: a multicenter study. (PMID 25336456) Xia H, et al. 2020. BMC Infect. Dis. 20(1):19 Value of pyrazinamide for composition of new treatment regimens for multidrug-resistant Mycobacterium tuberculosis in China. (PMID 31910878) Park SK, et al. 2001. BMC Infect Dis 1:4 pncA mutations in clinical Mycobacterium tuberculosis isolates from Korea. (PMID 11429043) Rajendran A, et al. 2022. Curr Microbiol 79(11):348 Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis: A Review and Update. (PMID 36209317) Ezewudo M, et al. 2018. Sci Rep 8(1):15382 Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. (PMID 30337678) The CRyPTIC Consortium 2022. PLoS Biol 20(8):e3001721 A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics. (PMID 35944069) World Health Organization. 2023. ISBN 978-92-4-008241-0. Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance. Second Edition. (ISBN 978-92-4-008241-0) Xavier V AM, et al. 2024. Indian J Tuberc 71 Suppl 1:S81-S85 Pyrazinamide resistance due to pncA gene mutation and its association with treatment outcome among tuberculosis patients of South India- A longitudinal observational study. (PMID 39067961) |
Prevalence of Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI | GRDI-AMR2 |
|---|---|---|---|---|---|
| Mycobacterium tuberculosis | 20.49% | 0% | 11.69% | 0% | 0% |
Model Type: protein variant model
Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.
Bit-score Cut-off (blastP): 300
PubMed: mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). CRyPTIC: mutation data acquired from the CRyPTIC catalog, evaluated as resistant (R), susceptible (S), or undetermined (U). ReSeqTB: mutation data acquired from the ReSeqTB catalog, evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. WHO: mutation data acquired from the WHO 2023 catalog, evaluated as resistant (R), susceptible (S), or undetermined (U).| Mutation | Mutation type | PubMed | ReSeqTB | CRyPTIC | WHO |
|---|---|---|---|---|---|
| M1L | single resistance variant | no data | no data | CRyPTIC-R | WHO-S |
| M1S | single resistance variant | PMID:11641519 | no data | no data | no data |
| M1Var | single resistance variant | no data | no data | no data | WHO-R |
| A3A | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| A3fs | frameshift mutation | no data | no data | no data | WHO-R |
| A3E | single resistance variant | PMID:17596354 | no data | CRyPTIC-R | WHO-R |
| L4S | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| L4V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| L4Ter | nonsense mutation | no data | no data | CRyPTIC-R | no data |
| L4fs | frameshift mutation | no data | no data | no data | WHO-R |
| L4F | single resistance variant | no data | no data | CRyPTIC-R | no data |
| L4W | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| I5S | single resistance variant | PMID:9055989 | no data | no data | WHO-R |
| I5M | single resistance variant | no data | no data | CRyPTIC-R | no data |
| I5F | single resistance variant | no data | no data | CRyPTIC-R | no data |
| I5T | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | no data |
| I5N | single resistance variant | no data | no data | CRyPTIC-R | no data |
| I6M | single resistance variant | no data | no data | CRyPTIC-R | no data |
| I6T | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| I6F | single resistance variant | no data | no data | CRyPTIC-R | no data |
| I6fs | frameshift mutation | no data | no data | no data | WHO-R |
| -7t>c | nucleotide substitution in promoter region | no data | no data | CRyPTIC-R | WHO-R |
| V7L | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| V7D | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | no data |
| V7fs | frameshift mutation | no data | no data | no data | WHO-R |
| V7F | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| V7A | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| V7G | single resistance variant | PMID:10390239 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| D8V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D8A | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| D8fs | frameshift mutation | no data | no data | no data | WHO-R |
| D8H | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| D8Y | single resistance variant | PMID:10390239 | no data | CRyPTIC-R | WHO-R |
| D8E | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| D8G | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| D8N | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| V9A | single resistance variant | PMID:31910878 | no data | no data | WHO-U |
| V9G | single resistance variant | PMID:11641519 | no data | no data | WHO-R |
| Q10Ter | nonsense mutation | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| Q10R | single resistance variant | PMID:10681313 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| Q10P,Y99D | multiple resistance variants | PMID:11641519 | no data | no data | no data |
| Q10H | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| Q10K | single resistance variant | PMID:10390239 | no data | no data | WHO-U |
| Q10P | single resistance variant | PMID:17596354 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| Q10L | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| Q10E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| N11T | single resistance variant | no data | no data | CRyPTIC-R | no data |
| -11a>g | nucleotide substitution in promoter region | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| -11a>c | nucleotide substitution in promoter region | no data | ReSeqTB-Minimal | no data | WHO-R |
| -11a>t | nucleotide substitution in promoter region | no data | no data | no data | WHO-R |
| D12A | single resistance variant | PMID:10813147 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| D12E | single resistance variant | PMID:21300839 | no data | CRyPTIC-R | WHO-R |
| D12fs | frameshift mutation | no data | no data | no data | WHO-R |
| -12t>c | nucleotide substitution in promoter region | no data | no data | CRyPTIC-R | WHO-R |
| D12Y | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D12N | single resistance variant | PMID:9055989 | no data | CRyPTIC-R | WHO-R |
| D12G | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| D12H | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| F13S | single resistance variant | no data | no data | no data | WHO-R |
| F13I | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| F13Y | single resistance variant | no data | no data | CRyPTIC-R | no data |
| F13fs | frameshift mutation | no data | no data | no data | WHO-R |
| F13V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| F13L | single resistance variant | no data | no data | no data | WHO-R |
| C14Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| C14W | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| C14Y | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | WHO-U |
| C14R | single resistance variant | PMID:11641519 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| E15Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| E15fs | frameshift mutation | no data | no data | no data | WHO-R |
| G16R | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G16G | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| G16V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G17S | single resistance variant | PMID:31910878 | no data | CRyPTIC-S | no data |
| G17D | single resistance variant | PMID:9692180 | no data | CRyPTIC-R | WHO-R |
| G17fs | frameshift mutation | no data | no data | no data | WHO-R |
| G17C | single resistance variant | no data | no data | CRyPTIC-R | no data |
| S18Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| S18T | single resistance variant | no data | no data | CRyPTIC-R | no data |
| S18L | single resistance variant | no data | no data | CRyPTIC-R | no data |
| S18fs | frameshift mutation | no data | no data | no data | WHO-R |
| L19P | single resistance variant | PMID:10813147 | no data | CRyPTIC-R | WHO-R |
| L19L | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| L19Q | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A20fs | frameshift mutation | no data | no data | no data | WHO-R |
| V21G | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| V21fs | frameshift mutation | no data | no data | no data | WHO-R |
| V21A | single resistance variant | no data | no data | CRyPTIC-R | WHO-S |
| V21E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| T22I | single resistance variant | no data | no data | CRyPTIC-R | no data |
| T22fs | frameshift mutation | no data | no data | no data | WHO-R |
| G23fs | frameshift mutation | no data | no data | no data | WHO-R |
| G23V | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | no data |
| G24V | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| G24fs | frameshift mutation | no data | no data | no data | WHO-R |
| G24D | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| A25E,A26G,A28D | multiple resistance variants | PMID:11641519 | no data | no data | no data |
| A26fs | frameshift mutation | no data | no data | no data | WHO-R |
| A26V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A26G | single resistance variant | PMID:9055989 | no data | no data | no data |
| L27Q | single resistance variant | no data | no data | CRyPTIC-R | no data |
| L27P | single resistance variant | PMID:17596354 | no data | CRyPTIC-R | WHO-R |
| A28S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A28fs | frameshift mutation | no data | no data | no data | WHO-R |
| R29fs | frameshift mutation | no data | no data | no data | WHO-R |
| R29C | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A30S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A30V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A30P | single resistance variant | no data | no data | CRyPTIC-R | no data |
| I31N | single resistance variant | no data | no data | CRyPTIC-R | no data |
| I31S | single resistance variant | no data | no data | no data | WHO-R |
| I31F | single resistance variant | no data | no data | CRyPTIC-R | no data |
| I31T | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| S32I | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| S32fs | frameshift mutation | no data | no data | no data | WHO-R |
| S32N | single resistance variant | no data | no data | CRyPTIC-R | no data |
| Y34D | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| Y34Ter | nonsense mutation | no data | no data | no data | WHO-R |
| Y34Y | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| Y34S | single resistance variant | PMID:9692180 | no data | no data | WHO-R |
| L35P | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| A36fs | frameshift mutation | no data | no data | no data | WHO-R |
| A36S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A36D | single resistance variant | no data | no data | CRyPTIC-R | no data |
| E37Ter | nonsense mutation | no data | no data | CRyPTIC-R | no data |
| E37fs | frameshift mutation | no data | no data | no data | WHO-R |
| A38A | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| A38G | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A38S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A39fs | frameshift mutation | no data | no data | no data | WHO-R |
| D40fs | frameshift mutation | no data | no data | no data | WHO-R |
| Y41Y | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| Y41Ter | nonsense mutation | PMID:10813147 | no data | CRyPTIC-R | WHO-R |
| Y41H | single resistance variant | PMID:10813147 | no data | CRyPTIC-R | no data |
| H42fs | frameshift mutation | no data | no data | no data | WHO-R |
| H42Q | single resistance variant | no data | no data | CRyPTIC-R | no data |
| H42N | single resistance variant | no data | no data | CRyPTIC-R | no data |
| H43fs | frameshift mutation | no data | no data | no data | WHO-R |
| H43P | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| H43Q | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V44G | single resistance variant | no data | no data | no data | WHO-R |
| V44D | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V45fs | frameshift mutation | no data | no data | no data | WHO-R |
| V45G | single resistance variant | PMID:11641519 | no data | no data | WHO-U |
| A46E | single resistance variant | PMID:10681313 | no data | CRyPTIC-R | WHO-R |
| A46P | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A46A | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| A46V | single resistance variant | PMID:10681313 | no data | CRyPTIC-R | WHO-R |
| T47S | single resistance variant | PMID:10390239 | no data | CRyPTIC-R | no data |
| T47A | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| T47P | single resistance variant | PMID:10813147 | no data | no data | WHO-R |
| K48fs | frameshift mutation | no data | no data | no data | WHO-R |
| K48T | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| K48E | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| K48Ter | nonsense mutation | no data | no data | CRyPTIC-R | no data |
| D49V | single resistance variant | PMID:10390239 | no data | CRyPTIC-R | no data |
| D49N | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| D49A | single resistance variant | PMID:11641519 | no data | no data | WHO-R |
| D49E | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| D49H | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D49Y | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| D49G | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| D49fs | frameshift mutation | no data | no data | no data | WHO-R |
| F50F | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| H51L | single resistance variant | no data | no data | CRyPTIC-R | no data |
| H51Y | single resistance variant | PMID:10471589 | no data | CRyPTIC-R | WHO-R |
| H51fs | frameshift mutation | no data | no data | no data | WHO-R |
| H51N | single resistance variant | no data | no data | CRyPTIC-R | no data |
| H51D | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| H51Q | single resistance variant | PMID:17596354 | no data | CRyPTIC-R | WHO-R |
| H51P | single resistance variant | no data | no data | no data | WHO-R |
| H51R | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| I52T | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D53A | single resistance variant | PMID:10681313 | no data | no data | no data |
| P54Q | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| P54R | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| P54S | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| P54T | single resistance variant | PMID:9056006 | no data | CRyPTIC-R | WHO-R |
| P54L | single resistance variant | PMID:17596354 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| G55C | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G55fs | frameshift mutation | no data | no data | no data | WHO-R |
| D56D | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| D56fs | frameshift mutation | no data | no data | no data | WHO-R |
| H57R | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| H57D | single resistance variant | PMID:11641519 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| H57Q | single resistance variant | PMID:31910878 | no data | CRyPTIC-R | WHO-R |
| H57Y | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| H57fs | frameshift mutation | no data | no data | no data | WHO-R |
| H57L | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| H57N | single resistance variant | no data | no data | CRyPTIC-R | no data |
| H57P | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| F58S | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| F58I | single resistance variant | no data | no data | CRyPTIC-R | no data |
| F58C | single resistance variant | no data | no data | no data | WHO-R |
| F58L | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| S59F | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| S59P | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| T61fs | frameshift mutation | no data | no data | no data | WHO-R |
| T61P | single resistance variant | no data | no data | no data | WHO-R |
| P62Q | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| P62A | single resistance variant | no data | no data | CRyPTIC-R | no data |
| P62T | single resistance variant | no data | no data | no data | WHO-R |
| P62R | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| P62H | single resistance variant | PMID:10471589 | no data | no data | no data |
| P62S | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| P62P | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| P62L | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| D63Y | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D63Y,T142K | multiple resistance variants | PMID:31910878 | no data | no data | no data |
| D63H | single resistance variant | PMID:36209317 | no data | CRyPTIC-R | no data |
| D63G | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| D63A | single resistance variant | no data | no data | CRyPTIC-S | WHO-R |
| D63fs | frameshift mutation | no data | no data | no data | WHO-R |
| D63E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D63_S67del | deletion mutation from peptide sequence | no data | no data | no data | WHO-R |
| Y64fs | frameshift mutation | no data | no data | no data | WHO-R |
| Y64D | single resistance variant | PMID:11641519 | no data | CRyPTIC-S | WHO-R |
| Y64Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| S65fs | frameshift mutation | no data | no data | no data | WHO-R |
| S65F | single resistance variant | no data | no data | CRyPTIC-R | no data |
| S66P | single resistance variant | PMID:10390239 | no data | CRyPTIC-R | WHO-R |
| S66Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| S67Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| S67P | single resistance variant | PMID:11641519 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| W68G | single resistance variant | PMID:11641519 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| W68L | single resistance variant | PMID:9056006 | no data | CRyPTIC-R | WHO-R |
| W68C | single resistance variant | PMID:25336456 | no data | CRyPTIC-R | WHO-R |
| W68S | single resistance variant | PMID:11641519 | no data | no data | WHO-U |
| W68R | single resistance variant | PMID:11641519 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| W68Ter | nonsense mutation | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| P69R | single resistance variant | PMID:9055989 | ReSeqTB-High | no data | WHO-U |
| P69Q | single resistance variant | no data | no data | CRyPTIC-R | no data |
| P69L | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| P70S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| P70A | single resistance variant | no data | no data | CRyPTIC-R | no data |
| H71Y | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| H71P | single resistance variant | no data | no data | no data | WHO-R |
| H71N | single resistance variant | no data | no data | CRyPTIC-R | no data |
| H71D | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| H71R | single resistance variant | no data | ReSeqTB-Moderate | CRyPTIC-R | WHO-R |
| H71E | single resistance variant | PMID:10681313 | no data | no data | no data |
| H71Q | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| H71H | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| H71L | single resistance variant | no data | no data | CRyPTIC-R | no data |
| C72R | single resistance variant | PMID:10813147 | no data | CRyPTIC-R | WHO-R |
| C72F | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| C72Ter | nonsense mutation | no data | no data | CRyPTIC-R | no data |
| C72Y | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| C72W | single resistance variant | PMID:17596354 | no data | CRyPTIC-R | WHO-U |
| S74fs | frameshift mutation | no data | no data | no data | WHO-R |
| G75V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| T76I | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| T76fs | frameshift mutation | no data | no data | no data | WHO-R |
| T76P | single resistance variant | PMID:11641519 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| T76S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| P77S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G78fs | frameshift mutation | no data | no data | no data | WHO-R |
| G78S | single resistance variant | no data | no data | no data | WHO-R |
| G78D | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| G78V | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| G78C | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| A79fs | frameshift mutation | no data | no data | no data | WHO-R |
| A79A | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| A79P | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D80fs | frameshift mutation | no data | no data | no data | WHO-R |
| D80H | single resistance variant | no data | no data | CRyPTIC-R | no data |
| F81V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| F81S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| F81fs | frameshift mutation | no data | no data | no data | WHO-R |
| H82L | single resistance variant | no data | no data | CRyPTIC-R | no data |
| H82R | single resistance variant | PMID:10681313 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| P83fs | frameshift mutation | no data | no data | no data | WHO-R |
| S84fs | frameshift mutation | no data | no data | no data | WHO-R |
| L85R | single resistance variant | PMID:10681313 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| L85P | single resistance variant | PMID:10813147 | no data | CRyPTIC-R | WHO-R |
| L85fs | frameshift mutation | no data | no data | no data | WHO-R |
| L85Q | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D86V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D86fs | frameshift mutation | no data | no data | no data | WHO-R |
| T87fs | frameshift mutation | no data | no data | no data | WHO-R |
| S88Ter | nonsense mutation | PMID:10813147 | no data | CRyPTIC-R | no data |
| S88T | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A89V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| I90N | single resistance variant | no data | no data | no data | WHO-R |
| I90S | single resistance variant | PMID:11158123 | no data | no data | WHO-R |
| I90T | single resistance variant | no data | no data | no data | WHO-R |
| E91Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| A92E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V93L | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| V93A | single resistance variant | no data | no data | no data | WHO-R |
| V93E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| F94L | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| F94fs | frameshift mutation | no data | no data | no data | WHO-R |
| F94C | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| F94F | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| F94S | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| F94P | single resistance variant | PMID:9056006 | no data | no data | no data |
| Y95fs | frameshift mutation | no data | no data | no data | WHO-R |
| Y95Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| Y95D | single resistance variant | no data | no data | no data | WHO-R |
| K96E | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| K96R | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| K96Ter | nonsense mutation | no data | no data | CRyPTIC-R | no data |
| K96M | single resistance variant | PMID:31910878 | no data | CRyPTIC-R | WHO-U |
| K96fs | frameshift mutation | no data | no data | no data | WHO-R |
| K96Q | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| K96T | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| K96N | single resistance variant | PMID:10813147 | no data | CRyPTIC-R | WHO-R |
| G97R | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| G97fs | frameshift mutation | no data | no data | no data | WHO-R |
| G97D | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| G97S | single resistance variant | PMID:10681313 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| G97V | single resistance variant | no data | no data | no data | WHO-R |
| G97C | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| A98fs | frameshift mutation | no data | no data | no data | WHO-R |
| Y99Ter | nonsense mutation | PMID:25336456 | no data | CRyPTIC-R | WHO-R |
| Y99fs | frameshift mutation | no data | no data | no data | WHO-R |
| T100P | single resistance variant | PMID:31910878 | ReSeqTB-High | no data | WHO-R |
| G101E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G101Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| A102P | single resistance variant | no data | no data | CRyPTIC-S | WHO-R |
| A102V | single resistance variant | PMID:10390239 | no data | no data | WHO-S |
| A102T | single resistance variant | PMID:10390239 | no data | no data | WHO-R |
| A102fs | frameshift mutation | no data | no data | no data | WHO-R |
| Y103Ter | nonsense mutation | PMID:11641519 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| Y103fs | frameshift mutation | no data | no data | no data | WHO-R |
| Y103H | single resistance variant | PMID:10471589 | no data | CRyPTIC-R | WHO-R |
| Y103S | single resistance variant | PMID:11641519 | no data | no data | WHO-U |
| Y103D | single resistance variant | no data | no data | no data | WHO-R |
| Y103C | single resistance variant | no data | no data | no data | WHO-R |
| S104I | single resistance variant | no data | no data | no data | WHO-R |
| S104C | single resistance variant | PMID:11158123 | no data | CRyPTIC-R | no data |
| S104_G108del | deletion mutation from peptide sequence | no data | no data | no data | WHO-R |
| S104G | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| S104R | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| G105D | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| G105R | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G105V | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| F106S | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| F106L | single resistance variant | no data | no data | no data | WHO-R |
| F106fs | frameshift mutation | no data | no data | no data | WHO-R |
| F106Y | single resistance variant | no data | no data | CRyPTIC-R | no data |
| E107Ter | nonsense mutation | no data | no data | no data | WHO-R |
| E107E | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| G108Ter | nonsense mutation | no data | ReSeqTB-High | CRyPTIC-R | no data |
| G108E | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| G108R | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| V109L | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D110N | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D110H | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D110E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| E111Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| N112fs | frameshift mutation | no data | no data | no data | WHO-R |
| N112S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| T114P | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| T114T | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| T114fs | frameshift mutation | no data | ReSeqTB-High | no data | WHO-R |
| T114A | single resistance variant | no data | no data | CRyPTIC-R | no data |
| P115A | single resistance variant | no data | no data | CRyPTIC-R | no data |
| P115R | single resistance variant | no data | no data | CRyPTIC-R | no data |
| P115fs | frameshift mutation | no data | no data | no data | WHO-R |
| L116P | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| L116R | single resistance variant | PMID:10390239 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| L116Q | single resistance variant | no data | no data | CRyPTIC-R | no data |
| L117Q | single resistance variant | no data | no data | CRyPTIC-R | no data |
| L117fs | frameshift mutation | no data | ReSeqTB-High | no data | WHO-R |
| N118Y | single resistance variant | no data | no data | CRyPTIC-R | no data |
| N118T | single resistance variant | PMID:10813147 | no data | no data | no data |
| N118N | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| W119L | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| W119Ter | nonsense mutation | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| W119fs | frameshift mutation | no data | no data | no data | WHO-R |
| W119G | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| W119R | single resistance variant | PMID:9056006 | no data | CRyPTIC-R | WHO-R |
| W119C | single resistance variant | no data | no data | no data | WHO-R |
| L120P | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| L120R | single resistance variant | no data | no data | no data | WHO-R |
| L120Q | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| R121P | single resistance variant | PMID:10813147 | no data | no data | WHO-R |
| Q122fs | frameshift mutation | no data | no data | no data | WHO-R |
| Q122K | single resistance variant | no data | no data | CRyPTIC-R | no data |
| Q122Ter | nonsense mutation | PMID:31910878 | no data | CRyPTIC-R | WHO-R |
| Q122Q | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| R123P | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| R123S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G124S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V125A | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V125F | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| V125D | single resistance variant | PMID:10390239 | no data | CRyPTIC-R | no data |
| V125fs | frameshift mutation | no data | no data | no data | WHO-R |
| V125G | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| V125V | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| D126_V130del | deletion mutation from peptide sequence | no data | no data | no data | WHO-R |
| D126fs | frameshift mutation | no data | no data | no data | WHO-R |
| E127Ter | nonsense mutation | no data | no data | CRyPTIC-R | no data |
| E127D | single resistance variant | no data | no data | CRyPTIC-R | no data |
| E127_D129del | deletion mutation from peptide sequence | no data | no data | no data | WHO-R |
| V128fs | frameshift mutation | no data | no data | no data | WHO-R |
| V128A | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V128D | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V128G | single resistance variant | no data | ReSeqTB-Moderate | CRyPTIC-R | WHO-R |
| D129E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D129_V131del | deletion mutation from peptide sequence | no data | no data | no data | WHO-R |
| D129N | single resistance variant | no data | no data | CRyPTIC-S | WHO-R |
| D129fs | frameshift mutation | no data | no data | no data | WHO-R |
| V130M | single resistance variant | no data | no data | no data | WHO-R |
| V130G | single resistance variant | no data | no data | no data | WHO-R |
| V130fs | frameshift mutation | no data | no data | no data | WHO-R |
| V130E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V131fs | frameshift mutation | no data | ReSeqTB-High | no data | WHO-R |
| V131I | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V131F | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| V131G | single resistance variant | no data | no data | no data | WHO-R |
| V131D | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G132C | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| G132fs | frameshift mutation | no data | no data | no data | WHO-R |
| G132D | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| G132R | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G132V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G132A | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| G132S | single resistance variant | PMID:17596354 | no data | CRyPTIC-R | WHO-R |
| I133T | single resistance variant | PMID:17596354 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| I133F | single resistance variant | no data | no data | CRyPTIC-R | no data |
| I133fs | frameshift mutation | no data | no data | no data | WHO-R |
| I133N | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| A134V | single resistance variant | PMID:10681313 | no data | CRyPTIC-R | WHO-R |
| A134P | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| T135P | single resistance variant | PMID:11641519 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| T135I | single resistance variant | no data | no data | CRyPTIC-R | no data |
| T135N | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| T135S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| D136Y | single resistance variant | PMID:17596354 | ReSeqTB-High | CRyPTIC-R | WHO-U |
| D136H | single resistance variant | PMID:10471589 | no data | CRyPTIC-R | WHO-U |
| D136V | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| D136fs | frameshift mutation | no data | ReSeqTB-High | no data | WHO-R |
| D136N | single resistance variant | PMID:11641519 | no data | CRyPTIC-R | no data |
| D136G | single resistance variant | no data | no data | no data | WHO-R |
| H137R | single resistance variant | PMID:9056006 | no data | CRyPTIC-R | WHO-S |
| H137P | single resistance variant | PMID:10471589 | no data | CRyPTIC-R | WHO-R |
| H137D | single resistance variant | no data | no data | CRyPTIC-R | no data |
| C138Ter | nonsense mutation | no data | no data | CRyPTIC-R | no data |
| C138G | single resistance variant | no data | no data | CRyPTIC-R | no data |
| C138Y | single resistance variant | PMID:10813147 | no data | CRyPTIC-R | no data |
| C138R | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| C138S | single resistance variant | PMID:10681313 | no data | CRyPTIC-R | WHO-U |
| C138W | single resistance variant | PMID:31910878 | no data | no data | no data |
| C138F | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V139G | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| V139E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V139A | single resistance variant | PMID:10813147 | no data | CRyPTIC-R | WHO-R |
| V139L | single resistance variant | PMID:10813147 | no data | CRyPTIC-R | WHO-R |
| V139M | single resistance variant | PMID:10681313 | no data | CRyPTIC-R | WHO-R |
| R140fs | frameshift mutation | no data | no data | no data | WHO-R |
| R140S | single resistance variant | PMID:10681313 | no data | no data | no data |
| R140G | single resistance variant | PMID:31910878 | no data | no data | no data |
| R140P | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| Q141P | single resistance variant | PMID:10681313 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| Q141Ter | nonsense mutation | PMID:11641519 | no data | CRyPTIC-R | WHO-R |
| T142R | single resistance variant | no data | no data | CRyPTIC-R | no data |
| T142P | single resistance variant | no data | no data | no data | WHO-R |
| T142A | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| T142T | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| T142K | single resistance variant | PMID:10813147 | no data | CRyPTIC-R | WHO-R |
| T142M | single resistance variant | PMID:10471589 | no data | CRyPTIC-R | WHO-R |
| A143D | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A143fs | frameshift mutation | no data | no data | no data | WHO-R |
| A143G | single resistance variant | no data | no data | no data | WHO-R |
| E144Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| E144fs | frameshift mutation | no data | no data | no data | WHO-R |
| D145E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A146E | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| A146T | single resistance variant | PMID:11641519 | no data | CRyPTIC-S | WHO-R |
| A146V | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| A146S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V147A | single resistance variant | no data | no data | CRyPTIC-R | no data |
| N149fs | frameshift mutation | no data | no data | no data | WHO-R |
| N149I | single resistance variant | no data | no data | CRyPTIC-R | no data |
| N149Y | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G150fs | frameshift mutation | no data | no data | no data | WHO-R |
| G150G | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| L151Ter | nonsense mutation | no data | no data | CRyPTIC-R | no data |
| L151fs | frameshift mutation | no data | no data | no data | WHO-R |
| L151S | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| A152fs | frameshift mutation | no data | no data | no data | WHO-R |
| A152V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| T153fs | frameshift mutation | no data | no data | no data | WHO-R |
| T153N | single resistance variant | no data | no data | CRyPTIC-R | no data |
| R154fs | frameshift mutation | no data | no data | no data | WHO-R |
| R154W | single resistance variant | PMID:31910878 | no data | no data | no data |
| R154M | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| R154G | single resistance variant | PMID:10390239 | no data | no data | WHO-R |
| V155fs | frameshift mutation | no data | no data | no data | WHO-R |
| V155G | single resistance variant | PMID:10681313 | no data | CRyPTIC-R | WHO-R |
| V155M | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| V155A | single resistance variant | no data | no data | no data | WHO-R |
| V155E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| L156R | single resistance variant | no data | no data | CRyPTIC-R | no data |
| L156fs | frameshift mutation | no data | no data | no data | WHO-R |
| L156P | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| V157G | single resistance variant | PMID:31910878 | no data | no data | WHO-U |
| V157fs | frameshift mutation | no data | no data | no data | WHO-R |
| D158fs | frameshift mutation | no data | no data | no data | WHO-R |
| D158G | single resistance variant | no data | no data | CRyPTIC-R | no data |
| L159fs | frameshift mutation | no data | no data | no data | WHO-R |
| L159V | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| L159R | single resistance variant | PMID:11641519 | no data | no data | WHO-R |
| L159P | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| L159Q | single resistance variant | no data | no data | CRyPTIC-R | no data |
| T160P | single resistance variant | PMID:10390239 | no data | CRyPTIC-R | WHO-R |
| T160R | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| T160K | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| A161P | single resistance variant | PMID:10390239 | no data | CRyPTIC-R | WHO-U |
| A161fs | frameshift mutation | no data | no data | no data | WHO-R |
| A161G | single resistance variant | PMID:31910878 | no data | no data | no data |
| G162D | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| G162V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| G162A | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V163fs | frameshift mutation | no data | no data | no data | WHO-R |
| V163E | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V163A | single resistance variant | no data | no data | no data | WHO-R |
| S164fs | frameshift mutation | no data | no data | no data | WHO-R |
| S164P | single resistance variant | PMID:31910878 | no data | CRyPTIC-R | WHO-R |
| S164S | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| S164T | single resistance variant | no data | no data | CRyPTIC-R | no data |
| S164Ter | nonsense mutation | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| A165D | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A165fs | frameshift mutation | no data | no data | no data | WHO-R |
| D166fs | frameshift mutation | no data | no data | no data | WHO-R |
| D166V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| T168N | single resistance variant | PMID:10681313 | no data | no data | no data |
| T168P | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| A170V | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A170S | single resistance variant | no data | no data | CRyPTIC-R | no data |
| A171E | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| A171V | single resistance variant | PMID:10471589 | no data | no data | no data |
| A171P | single resistance variant | PMID:9055989 | no data | no data | WHO-R |
| A171T | single resistance variant | PMID:10471589 | no data | CRyPTIC-R | WHO-U |
| A171A | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| L172fs | frameshift mutation | no data | no data | no data | WHO-R |
| L172A | single resistance variant | PMID:10471589 | no data | no data | no data |
| L172P | single resistance variant | PMID:31910878 | no data | CRyPTIC-R | WHO-R |
| E173fs | frameshift mutation | no data | no data | no data | WHO-R |
| E173G | single resistance variant | no data | no data | CRyPTIC-R | no data |
| E173Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| E174K | single resistance variant | no data | no data | CRyPTIC-R | no data |
| E174G | single resistance variant | PMID:31910878 | no data | CRyPTIC-R | no data |
| E174Ter | nonsense mutation | no data | no data | no data | WHO-R |
| M175I | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| M175R | single resistance variant | no data | no data | no data | WHO-R |
| M175K | single resistance variant | no data | no data | CRyPTIC-R | no data |
| M175T | single resistance variant | no data | no data | CRyPTIC-R | WHO-R |
| M175V | single resistance variant | PMID:17596354 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| M175fs | frameshift mutation | no data | no data | no data | WHO-R |
| R176P | single resistance variant | no data | no data | CRyPTIC-R | no data |
| T177fs | frameshift mutation | no data | no data | no data | WHO-R |
| T177T | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| T177P | single resistance variant | no data | no data | no data | WHO-R |
| A178_S179del | deletion mutation from peptide sequence | no data | no data | no data | WHO-R |
| A178fs | frameshift mutation | no data | no data | no data | WHO-R |
| S179N | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V180A | single resistance variant | no data | ReSeqTB-High | no data | WHO-R |
| V180G | single resistance variant | no data | ReSeqTB-High | CRyPTIC-R | WHO-R |
| V180D | single resistance variant | no data | no data | CRyPTIC-R | WHO-U |
| V180F | single resistance variant | PMID:11641519 | ReSeqTB-High | CRyPTIC-R | WHO-R |
| E181Ter | nonsense mutation | no data | no data | CRyPTIC-R | WHO-R |
| E181fs | frameshift mutation | no data | no data | no data | WHO-R |
| E181K | single resistance variant | no data | no data | CRyPTIC-R | no data |
| L182S | single resistance variant | PMID:31910878 | ReSeqTB-High | CRyPTIC-S | WHO-R |
| L182W | single resistance variant | no data | no data | no data | WHO-R |
| V183D | single resistance variant | no data | no data | CRyPTIC-R | no data |
| V183V | synonymous substitution for alternative promoter | no data | no data | CRyPTIC-R | no data |
| C184R | single resistance variant | no data | no data | CRyPTIC-R | no data |
| S186F | single resistance variant | no data | no data | CRyPTIC-R | no data |
| Curator | Description | Most Recent Edit |
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