Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide

Accession ARO:3003394
Synonym(s)Rv2043c
CARD Short NameMtub_pncA_PZA
DefinitionpncA is a pyrazinamidase/nicotinamidase. It catalyzes the activation of pyrazinamide. Some mutation within pncA are associated with loss of enzyme activity, resulting in pyrazinamide resistance.
AMR Gene FamilyPyrazinamide resistant pncA
Drug Classpyrazine antibiotic
Resistance Mechanismantibiotic target alteration
Resistomes with Sequence VariantsMycobacterium tuberculosisg+wgs
Classification9 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ confers_resistance_to_antibiotic pyrazinamide [Antibiotic]
+ Pyrazinamide resistant pncA [AMR Gene Family]
Publications

Campbell PJ, et al. 2011. Antimicrob Agents Chemother 55(5): 2032-2041. Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis. (PMID 21300839)

Scorpio A, et al. 1997. Antimicrob Agents Chemother 41(3): 540-543. Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis. (PMID 9055989)

Lemaitre N, et al. 1999. Antimicrob Agents Chemother 43(7): 1761-1763. Characterization of new mutations in pyrazinamide-resistant strains of Mycobacterium tuberculosis and identification of conserved regions important for the catalytic activity of the pyrazinamidase PncA. (PMID 10390238)

Hirano K, et al. 1998. Tuber Lung Dis 78(2): 117-122. Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis. (PMID 9692180)

Cheng SJ, et al. 2000. Antimicrob Agents Chemother 44(3): 528-532. pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada. (PMID 10681313)

Hou L, et al. 2000. Epidemiol Infect 124(2): 227-232. Molecular characterization of pncA gene mutations in Mycobacterium tuberculosis clinical isolates from China. (PMID 10813147)

Chan RC, et al. 2007. J Antimicrob Chemother 59(5): 866-873. Genetic and phenotypic characterization of drug-resistant Mycobacterium tuberculosis isolates in Hong Kong. (PMID 17360809)

Stavrum R, et al. 2009. PLoS One 4(2): E4540. In-depth molecular characterization of Mycobacterium tuberculosis from New Delhi--predominance of drug resistant isolates of the 'modern' (TbD1) type. (PMID 19234602)

Morlock GP, et al. 2000. Antimicrob Agents Chemother 44(12): 3298-3301. Characterization of spontaneous, In vitro-selected, rifampin-resistant mutants of Mycobacterium tuberculosis strain H37Rv. (PMID 11083630)

Marttila HJ, et al. 1999. Antimicrob. Agents Chemother. 43(7):1764-6 pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia. (PMID 10390239)

Sreevatsan S, et al. 1997. Antimicrob. Agents Chemother. 41(3):636-40 Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms. (PMID 9056006)

Hannan MM, et al. 2001. J. Clin. Microbiol. 39(2):647-50 Pyrazinamide-monoresistant Mycobacterium tuberculosis in the United States. (PMID 11158123)

Lee KW, et al. 2001. J. Korean Med. Sci. 16(5):537-43 Characterization of pncA mutations of pyrazinamide-resistant Mycobacterium tuberculosis in Korea. (PMID 11641519)

Mestdagh M, et al. 1999. Antimicrob. Agents Chemother. 43(9):2317-9 Relationship between pyrazinamide resistance, loss of pyrazinamidase activity, and mutations in the pncA locus in multidrug-resistant clinical isolates of Mycobacterium tuberculosis. (PMID 10471589)

Sekiguchi J, et al. 2007. J. Clin. Microbiol. 45(9):2802-7 Development and evaluation of a line probe assay for rapid identification of pncA mutations in pyrazinamide-resistant mycobacterium tuberculosis strains. (PMID 17596354)

Miotto P, et al. 2014. MBio 5(5):e01819-14 Mycobacterium tuberculosis pyrazinamide resistance determinants: a multicenter study. (PMID 25336456)

Xia H, et al. 2020. BMC Infect. Dis. 20(1):19 Value of pyrazinamide for composition of new treatment regimens for multidrug-resistant Mycobacterium tuberculosis in China. (PMID 31910878)

Park SK, et al. 2001. BMC Infect Dis 1:4 pncA mutations in clinical Mycobacterium tuberculosis isolates from Korea. (PMID 11429043)

Rajendran A, et al. 2022. Curr Microbiol 79(11):348 Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis: A Review and Update. (PMID 36209317)

Ezewudo M, et al. 2018. Sci Rep 8(1):15382 Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase. (PMID 30337678)

The CRyPTIC Consortium 2022. PLoS Biol 20(8):e3001721 A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics. (PMID 35944069)

World Health Organization. 2023. ISBN 978-92-4-008241-0. Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance. Second Edition. (ISBN 978-92-4-008241-0)

Resistomes

Prevalence of Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein variant model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Mycobacterium tuberculosis20.49%0%11.69%0%0%
Show Perfect Only


Detection Models

Model Type: protein variant model

Model Definition: Protein Variant Models (PVM) perform a similar search as Protein Homolog Models (PHM), i.e. detect protein sequences based on their similarity to a curated reference sequence, but secondarily screen query sequences for curated sets of mutations to differentiate them from antibiotic susceptible wild-type alleles. PVMs are designed to detect AMR acquired via mutation of house-keeping genes or antibiotic targets, e.g. a mutated gyrase resistant to aminocoumarin antibiotics. PVMs include a protein reference sequence (often from antibiotic susceptible wild-type alleles), a curated bit-score cut-off, and mapped resistance variants. Mapped resistance variants may include any or all of single point mutations, insertions, or deletions curated from the scientific literature. A Strict RGI match has a BLASTP bit-score above the curated BLASTP cutoff value and contains at least one curated mutation from amongst the mapped resistance variants, while a Loose RGI match has a bit-score less than the curated BLASTP bit-score cut-off but still contains at least one curated mutation from amongst the mapped resistance variants.

Bit-score Cut-off (blastP): 300

PubMed: mutation data hand curated from the scientific literature, evaluated as conferring resistance (R). CRyPTIC: mutation data acquired from the CRyPTIC catalog, evaluated as resistant (R), susceptible (S), or undetermined (U). ReSeqTB: mutation data acquired from the ReSeqTB catalog, evaluated as conferring resistance (Minimal, Moderate, High), not conferring resistance (None), or Indeterminate. WHO: mutation data acquired from the WHO 2023 catalog, evaluated as resistant (R), susceptible (S), or undetermined (U).

MutationMutation typePubMedReSeqTBCRyPTICWHO
M1Lsingle resistance variantno datano dataCRyPTIC-RWHO-S
M1Varsingle resistance variantno datano datano dataWHO-R
M1Ssingle resistance variantPMID:11641519no datano datano data
-nt1:11deletion mutation from nucleotide sequencePMID:11429043no datano datano data
A3Asingle resistance variantno datano dataCRyPTIC-Rno data
A3Esingle resistance variantPMID:17596354no dataCRyPTIC-RWHO-R
L4Wsingle resistance variantPMID:11641519no dataCRyPTIC-RWHO-R
L4Fsingle resistance variantno datano dataCRyPTIC-Rno data
L4Ternonsense mutationno datano dataCRyPTIC-Rno data
L4Vsingle resistance variantno datano dataCRyPTIC-Rno data
L4Ssingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
I5Nsingle resistance variantno datano dataCRyPTIC-Rno data
I5Fsingle resistance variantno datano dataCRyPTIC-Rno data
I5Msingle resistance variantno datano dataCRyPTIC-Rno data
I5Tsingle resistance variantno dataReSeqTB-HighCRyPTIC-Rno data
I5Ssingle resistance variantPMID:9055989no datano dataWHO-R
I6Fsingle resistance variantno datano dataCRyPTIC-Rno data
I6Tsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
I6Msingle resistance variantno datano dataCRyPTIC-Rno data
V7Fsingle resistance variantPMID:11641519no dataCRyPTIC-RWHO-R
V7Dsingle resistance variantPMID:11641519no dataCRyPTIC-Rno data
V7Asingle resistance variantno datano dataCRyPTIC-RWHO-R
V7Lsingle resistance variantno datano dataCRyPTIC-RWHO-R
t-7csnp in promoter regionno datano dataCRyPTIC-RWHO-R
V7Gsingle resistance variantPMID:10390239ReSeqTB-HighCRyPTIC-RWHO-R
D8Asingle resistance variantno datano dataCRyPTIC-RWHO-R
D8Esingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
D8Gsingle resistance variantPMID:11641519no dataCRyPTIC-RWHO-R
D8Vsingle resistance variantno datano dataCRyPTIC-Rno data
D8Nsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
D8Hsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
D8Ysingle resistance variantPMID:10390239no dataCRyPTIC-RWHO-R
V9Asingle resistance variantPMID:31910878no datano dataWHO-U
V9Gsingle resistance variantPMID:11641519no datano dataWHO-R
Q10Esingle resistance variantno datano dataCRyPTIC-Rno data
Q10P,Y99Dmultiple resistance variantsPMID:11641519no datano datano data
Q10Ksingle resistance variantPMID:10390239no datano dataWHO-U
Q10Ternonsense mutationPMID:11641519no dataCRyPTIC-RWHO-R
Q10Hsingle resistance variantno datano dataCRyPTIC-RWHO-R
Q10Rsingle resistance variantPMID:10681313ReSeqTB-HighCRyPTIC-RWHO-R
Q10Lsingle resistance variantno datano dataCRyPTIC-RWHO-U
Q10Psingle resistance variantPMID:17596354ReSeqTB-HighCRyPTIC-RWHO-R
a-11tsnp in promoter regionno datano datano dataWHO-R
a-11csnp in promoter regionno dataReSeqTB-Minimalno dataWHO-R
a-11gsnp in promoter regionno dataReSeqTB-HighCRyPTIC-RWHO-R
N11Tsingle resistance variantno datano dataCRyPTIC-Rno data
D12Nsingle resistance variantPMID:9055989no dataCRyPTIC-RWHO-R
D12Gsingle resistance variantno datano dataCRyPTIC-RWHO-R
D12Ysingle resistance variantno datano dataCRyPTIC-Rno data
D12Asingle resistance variantPMID:10813147ReSeqTB-HighCRyPTIC-RWHO-R
D12Esingle resistance variantPMID:21300839no dataCRyPTIC-RWHO-R
t-12csnp in promoter regionno datano dataCRyPTIC-RWHO-R
D12Hsingle resistance variantno datano dataCRyPTIC-RWHO-U
F13Isingle resistance variantno datano dataCRyPTIC-RWHO-R
F13Ysingle resistance variantno datano dataCRyPTIC-Rno data
F13Vsingle resistance variantno datano dataCRyPTIC-Rno data
F13Ssingle resistance variantno datano datano dataWHO-R
F13Lsingle resistance variantno datano datano dataWHO-R
C14Ternonsense mutationno datano dataCRyPTIC-RWHO-R
C14Wsingle resistance variantno datano dataCRyPTIC-RWHO-R
C14Rsingle resistance variantPMID:11641519ReSeqTB-HighCRyPTIC-RWHO-R
C14Ysingle resistance variantPMID:11641519no dataCRyPTIC-RWHO-U
E15Ternonsense mutationno datano dataCRyPTIC-RWHO-R
G16Vsingle resistance variantno datano dataCRyPTIC-Rno data
G16Rsingle resistance variantno datano dataCRyPTIC-Rno data
G16Gsingle resistance variantno datano dataCRyPTIC-Rno data
G17Ssingle resistance variantPMID:31910878no dataCRyPTIC-Sno data
G17Dsingle resistance variantPMID:9692180no dataCRyPTIC-RWHO-R
G17Csingle resistance variantno datano dataCRyPTIC-Rno data
S18Tsingle resistance variantno datano dataCRyPTIC-Rno data
S18Lsingle resistance variantno datano dataCRyPTIC-Rno data
S18Ternonsense mutationno datano dataCRyPTIC-RWHO-R
L19Qsingle resistance variantno datano dataCRyPTIC-Rno data
L19Lsingle resistance variantno datano dataCRyPTIC-Rno data
L19Psingle resistance variantPMID:10813147no dataCRyPTIC-RWHO-R
V21Gsingle resistance variantno datano dataCRyPTIC-RWHO-R
V21Esingle resistance variantno datano dataCRyPTIC-Rno data
V21Asingle resistance variantno datano dataCRyPTIC-RWHO-S
T22Isingle resistance variantno datano dataCRyPTIC-Rno data
G23Vsingle resistance variantPMID:11641519no dataCRyPTIC-Rno data
G24Dsingle resistance variantno datano dataCRyPTIC-RWHO-R
G24Vsingle resistance variantno datano dataCRyPTIC-RWHO-U
A25E,A26G,A28Dmultiple resistance variantsPMID:11641519no datano datano data
A26Gsingle resistance variantPMID:9055989no datano datano data
A26Vsingle resistance variantno datano dataCRyPTIC-Rno data
L27Psingle resistance variantPMID:17596354no dataCRyPTIC-RWHO-R
L27Qsingle resistance variantno datano dataCRyPTIC-Rno data
-nt28:cdeletion mutation from nucleotide sequencePMID:9055989no datano datano data
A28Ssingle resistance variantno datano dataCRyPTIC-Rno data
R29Csingle resistance variantno datano dataCRyPTIC-Rno data
A30Psingle resistance variantno datano dataCRyPTIC-Rno data
A30Ssingle resistance variantno datano dataCRyPTIC-Rno data
A30Vsingle resistance variantno datano dataCRyPTIC-Rno data
I31Fsingle resistance variantno datano dataCRyPTIC-Rno data
I31Tsingle resistance variantno datano dataCRyPTIC-RWHO-R
I31Ssingle resistance variantno datano datano dataWHO-R
I31Nsingle resistance variantno datano dataCRyPTIC-Rno data
S32Isingle resistance variantno datano dataCRyPTIC-RWHO-U
S32Nsingle resistance variantno datano dataCRyPTIC-Rno data
Y34Ysingle resistance variantno datano dataCRyPTIC-Rno data
Y34Ssingle resistance variantPMID:9692180no datano dataWHO-R
Y34Ternonsense mutationno datano datano dataWHO-R
Y34Dsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
L35Psingle resistance variantno datano dataCRyPTIC-RWHO-R
A36Dsingle resistance variantno datano dataCRyPTIC-Rno data
A36Ssingle resistance variantno datano dataCRyPTIC-Rno data
E37Ternonsense mutationno datano dataCRyPTIC-Rno data
A38Gsingle resistance variantno datano dataCRyPTIC-Rno data
A38Asingle resistance variantno datano dataCRyPTIC-Rno data
A38Ssingle resistance variantno datano dataCRyPTIC-Rno data
Y41Ysingle resistance variantno datano dataCRyPTIC-Rno data
Y41Hsingle resistance variantPMID:10813147no dataCRyPTIC-Rno data
Y41Ternonsense mutationPMID:10813147no dataCRyPTIC-RWHO-R
H42Nsingle resistance variantno datano dataCRyPTIC-Rno data
H42Qsingle resistance variantno datano dataCRyPTIC-Rno data
H43Qsingle resistance variantno datano dataCRyPTIC-Rno data
H43Psingle resistance variantno datano dataCRyPTIC-RWHO-R
V44Gsingle resistance variantno datano datano dataWHO-R
V44Dsingle resistance variantno datano dataCRyPTIC-Rno data
V45Gsingle resistance variantPMID:11641519no datano dataWHO-U
A46Vsingle resistance variantPMID:10681313no dataCRyPTIC-RWHO-R
A46Psingle resistance variantno datano dataCRyPTIC-Rno data
A46Esingle resistance variantPMID:10681313no dataCRyPTIC-RWHO-R
A46Asingle resistance variantno datano dataCRyPTIC-Rno data
T47Asingle resistance variantPMID:11641519no dataCRyPTIC-RWHO-R
T47Ssingle resistance variantPMID:10390239no dataCRyPTIC-Rno data
T47Psingle resistance variantPMID:10813147no datano dataWHO-R
K48Ternonsense mutationno datano dataCRyPTIC-Rno data
K48Tsingle resistance variantno datano dataCRyPTIC-RWHO-R
K48Esingle resistance variantno datano dataCRyPTIC-RWHO-R
D49Esingle resistance variantno datano dataCRyPTIC-RWHO-R
D49Asingle resistance variantPMID:11641519no datano dataWHO-R
D49Ysingle resistance variantno datano dataCRyPTIC-RWHO-U
D49Hsingle resistance variantno datano dataCRyPTIC-Rno data
D49Vsingle resistance variantPMID:10390239no dataCRyPTIC-Rno data
D49Nsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
D49Gsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
F50Fsingle resistance variantno datano dataCRyPTIC-Rno data
H51Lsingle resistance variantno datano dataCRyPTIC-Rno data
H51Psingle resistance variantno datano datano dataWHO-R
H51Rsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
H51Qsingle resistance variantPMID:17596354no dataCRyPTIC-RWHO-R
H51Nsingle resistance variantno datano dataCRyPTIC-Rno data
H51Ysingle resistance variantPMID:10471589no dataCRyPTIC-RWHO-R
H51Dsingle resistance variantno datano dataCRyPTIC-RWHO-R
+nt52:ginsertion mutation from nucleotide sequencePMID:10681313no datano datano data
I52Tsingle resistance variantno datano dataCRyPTIC-Rno data
D53N,+nt349:CACTGmultiple resistance variantsPMID:17596354no datano datano data
D53Asingle resistance variantPMID:10681313no datano datano data
P54Lsingle resistance variantPMID:17596354ReSeqTB-HighCRyPTIC-RWHO-R
P54Tsingle resistance variantPMID:9056006no dataCRyPTIC-RWHO-R
P54Ssingle resistance variantno datano dataCRyPTIC-RWHO-R
P54Qsingle resistance variantno datano dataCRyPTIC-RWHO-R
P54Rsingle resistance variantno datano dataCRyPTIC-RWHO-R
G55Csingle resistance variantno datano dataCRyPTIC-Rno data
D56Dsingle resistance variantno datano dataCRyPTIC-Rno data
H57Dsingle resistance variantPMID:11641519ReSeqTB-HighCRyPTIC-RWHO-R
H57Qsingle resistance variantPMID:31910878no dataCRyPTIC-RWHO-R
H57Lsingle resistance variantno datano dataCRyPTIC-RWHO-R
H57Ysingle resistance variantno datano dataCRyPTIC-RWHO-R
H57Psingle resistance variantno datano dataCRyPTIC-RWHO-U
H57Rsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
H57Nsingle resistance variantno datano dataCRyPTIC-Rno data
F58Csingle resistance variantno datano datano dataWHO-R
F58Lsingle resistance variantPMID:11641519no dataCRyPTIC-RWHO-R
F58Isingle resistance variantno datano dataCRyPTIC-Rno data
F58Ssingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
S59Psingle resistance variantno datano dataCRyPTIC-RWHO-R
S59Fsingle resistance variantno datano dataCRyPTIC-RWHO-U
T61Psingle resistance variantno datano datano dataWHO-R
P62Hsingle resistance variantPMID:10471589no datano datano data
P62Qsingle resistance variantno datano dataCRyPTIC-RWHO-U
P62Asingle resistance variantno datano dataCRyPTIC-Rno data
P62Lsingle resistance variantno datano dataCRyPTIC-RWHO-R
P62Ssingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
P62Tsingle resistance variantno datano datano dataWHO-R
P62Psingle resistance variantno datano dataCRyPTIC-Rno data
P62Rsingle resistance variantno datano dataCRyPTIC-RWHO-R
D63Hsingle resistance variantPMID:36209317no dataCRyPTIC-Rno data
D63Asingle resistance variantno datano dataCRyPTIC-SWHO-R
D63Y,T142Kmultiple resistance variantsPMID:31910878no datano datano data
D63Gsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
D63Ysingle resistance variantno datano dataCRyPTIC-Rno data
D63Esingle resistance variantno datano dataCRyPTIC-Rno data
Y64Dsingle resistance variantPMID:11641519no dataCRyPTIC-SWHO-R
Y64Ternonsense mutationno datano dataCRyPTIC-RWHO-R
S65Fsingle resistance variantno datano dataCRyPTIC-Rno data
S66Ternonsense mutationno datano dataCRyPTIC-RWHO-R
S66Psingle resistance variantPMID:10390239no dataCRyPTIC-RWHO-R
S67Psingle resistance variantPMID:11641519ReSeqTB-HighCRyPTIC-RWHO-R
S67Ternonsense mutationno datano dataCRyPTIC-RWHO-R
W68Ssingle resistance variantPMID:11641519no datano dataWHO-U
W68Ternonsense mutationPMID:11641519no dataCRyPTIC-RWHO-R
W68Lsingle resistance variantPMID:9056006no dataCRyPTIC-RWHO-R
W68Rsingle resistance variantPMID:11641519ReSeqTB-HighCRyPTIC-RWHO-R
W68Csingle resistance variantPMID:25336456no dataCRyPTIC-RWHO-R
W68Gsingle resistance variantPMID:11641519ReSeqTB-HighCRyPTIC-RWHO-R
P69Rsingle resistance variantPMID:9055989ReSeqTB-Highno dataWHO-U
P69Lsingle resistance variantno datano dataCRyPTIC-RWHO-R
P69Qsingle resistance variantno datano dataCRyPTIC-Rno data
P70Asingle resistance variantno datano dataCRyPTIC-Rno data
P70Ssingle resistance variantno datano dataCRyPTIC-Rno data
-nt70:gdeletion mutation from nucleotide sequencecuration underwayno datano datano data
-nt71:gdeletion mutation from nucleotide sequencePMID:9055989no datano datano data
H71Lsingle resistance variantno datano dataCRyPTIC-Rno data
H71Ysingle resistance variantno datano dataCRyPTIC-RWHO-R
H71Rsingle resistance variantno dataReSeqTB-ModerateCRyPTIC-RWHO-R
H71Hsingle resistance variantno datano dataCRyPTIC-Rno data
H71Psingle resistance variantno datano datano dataWHO-R
H71Esingle resistance variantPMID:10681313no datano datano data
H71Qsingle resistance variantno datano dataCRyPTIC-RWHO-U
H71Dsingle resistance variantno datano dataCRyPTIC-RWHO-R
H71Nsingle resistance variantno datano dataCRyPTIC-Rno data
C72Fsingle resistance variantno datano dataCRyPTIC-RWHO-U
C72Ternonsense mutationno datano dataCRyPTIC-Rno data
C72Wsingle resistance variantPMID:17596354no dataCRyPTIC-RWHO-U
C72Ysingle resistance variantno datano dataCRyPTIC-RWHO-R
C72Rsingle resistance variantPMID:10813147no dataCRyPTIC-RWHO-R
G75Vsingle resistance variantno datano dataCRyPTIC-Rno data
T76Isingle resistance variantPMID:11641519no dataCRyPTIC-RWHO-R
T76Psingle resistance variantPMID:11641519ReSeqTB-HighCRyPTIC-RWHO-R
T76Ssingle resistance variantno datano dataCRyPTIC-Rno data
P77Ssingle resistance variantno datano dataCRyPTIC-Rno data
-nt77:gdeletion mutation from nucleotide sequencecuration underwayno datano datano data
G78Ssingle resistance variantno datano datano dataWHO-R
G78Csingle resistance variantno datano dataCRyPTIC-RWHO-U
G78Vsingle resistance variantno datano dataCRyPTIC-RWHO-R
G78Dsingle resistance variantPMID:11641519no dataCRyPTIC-RWHO-R
A79Psingle resistance variantno datano dataCRyPTIC-Rno data
A79Asingle resistance variantno datano dataCRyPTIC-Rno data
D80Hsingle resistance variantno datano dataCRyPTIC-Rno data
F81Ssingle resistance variantno datano dataCRyPTIC-Rno data
F81Vsingle resistance variantno datano dataCRyPTIC-Rno data
H82Rsingle resistance variantPMID:10681313ReSeqTB-HighCRyPTIC-RWHO-R
H82Lsingle resistance variantno datano dataCRyPTIC-Rno data
-nt84:cdeletion mutation from nucleotide sequencecuration underwayno datano datano data
L85Rsingle resistance variantPMID:10681313ReSeqTB-HighCRyPTIC-RWHO-R
L85Psingle resistance variantPMID:10813147no dataCRyPTIC-RWHO-R
L85Qsingle resistance variantno datano dataCRyPTIC-Rno data
D86Vsingle resistance variantno datano dataCRyPTIC-Rno data
S88Ternonsense mutationPMID:10813147no dataCRyPTIC-Rno data
S88Tsingle resistance variantno datano dataCRyPTIC-Rno data
A89Vsingle resistance variantno datano dataCRyPTIC-Rno data
I90Tsingle resistance variantno datano datano dataWHO-R
I90Nsingle resistance variantno datano datano dataWHO-R
I90Ssingle resistance variantPMID:11158123no datano dataWHO-R
E91Ternonsense mutationno datano dataCRyPTIC-RWHO-R
A92Esingle resistance variantno datano dataCRyPTIC-Rno data
V93Asingle resistance variantno datano datano dataWHO-R
V93Esingle resistance variantno datano dataCRyPTIC-Rno data
V93Lsingle resistance variantno datano dataCRyPTIC-RWHO-R
F94Psingle resistance variantPMID:9056006no datano datano data
F94Ssingle resistance variantno datano dataCRyPTIC-RWHO-R
F94Lsingle resistance variantno datano dataCRyPTIC-RWHO-R
F94Csingle resistance variantno datano dataCRyPTIC-RWHO-R
F94Fsingle resistance variantno datano dataCRyPTIC-Rno data
Y95Ternonsense mutationno datano dataCRyPTIC-RWHO-R
Y95Dsingle resistance variantno datano datano dataWHO-R
K96Msingle resistance variantPMID:31910878no dataCRyPTIC-RWHO-U
K96Nsingle resistance variantPMID:10813147no dataCRyPTIC-RWHO-R
K96Qsingle resistance variantPMID:11641519no dataCRyPTIC-RWHO-R
K96Rsingle resistance variantno datano dataCRyPTIC-RWHO-R
K96Tsingle resistance variantno datano dataCRyPTIC-RWHO-R
K96Ternonsense mutationno datano dataCRyPTIC-Rno data
K96Esingle resistance variantPMID:11641519no dataCRyPTIC-RWHO-R
G97Vsingle resistance variantno datano datano dataWHO-R
G97Rsingle resistance variantno datano dataCRyPTIC-RWHO-R
G97Csingle resistance variantno datano dataCRyPTIC-RWHO-R
G97Dsingle resistance variantno datano dataCRyPTIC-RWHO-R
G97Ssingle resistance variantPMID:10681313ReSeqTB-HighCRyPTIC-RWHO-R
Y99Ternonsense mutationPMID:25336456no dataCRyPTIC-RWHO-R
T100Psingle resistance variantPMID:31910878ReSeqTB-Highno dataWHO-R
G101Esingle resistance variantno datano dataCRyPTIC-Rno data
G101Ternonsense mutationno datano dataCRyPTIC-RWHO-R
A102Tsingle resistance variantPMID:10390239no datano dataWHO-R
A102Vsingle resistance variantPMID:10390239no datano dataWHO-S
A102Psingle resistance variantno datano dataCRyPTIC-SWHO-R
Y103Ssingle resistance variantPMID:11641519no datano dataWHO-U
Y103Dsingle resistance variantno datano datano dataWHO-R
Y103Csingle resistance variantno datano datano dataWHO-R
Y103Ternonsense mutationPMID:11641519ReSeqTB-HighCRyPTIC-RWHO-R
Y103Hsingle resistance variantPMID:10471589no dataCRyPTIC-RWHO-R
S104Isingle resistance variantno datano datano dataWHO-R
-nt104:cdeletion mutation from nucleotide sequencePMID:9055989no datano datano data
S104Csingle resistance variantPMID:11158123no dataCRyPTIC-Rno data
S104Gsingle resistance variantno datano dataCRyPTIC-RWHO-R
S104Rsingle resistance variantno datano dataCRyPTIC-RWHO-R
G105Dsingle resistance variantno datano dataCRyPTIC-RWHO-R
G105Rsingle resistance variantno datano dataCRyPTIC-Rno data
G105Vsingle resistance variantno datano dataCRyPTIC-RWHO-R
F106Lsingle resistance variantno datano datano dataWHO-R
F106Ysingle resistance variantno datano dataCRyPTIC-Rno data
F106Ssingle resistance variantno datano dataCRyPTIC-RWHO-R
E107Esingle resistance variantno datano dataCRyPTIC-Rno data
E107Ternonsense mutationno datano datano dataWHO-R
G108Esingle resistance variantno datano dataCRyPTIC-RWHO-R
G108Ternonsense mutationno dataReSeqTB-HighCRyPTIC-Rno data
G108Rsingle resistance variantno datano dataCRyPTIC-RWHO-R
V109Lsingle resistance variantno datano dataCRyPTIC-Rno data
D110Hsingle resistance variantno datano dataCRyPTIC-Rno data
D110Esingle resistance variantno datano dataCRyPTIC-Rno data
D110Nsingle resistance variantno datano dataCRyPTIC-Rno data
E111Ternonsense mutationno datano dataCRyPTIC-RWHO-R
N112Ssingle resistance variantno datano dataCRyPTIC-Rno data
T114fsframeshift mutationno dataReSeqTB-Highno datano data
T114Psingle resistance variantno datano dataCRyPTIC-RWHO-R
T114Tsingle resistance variantno datano dataCRyPTIC-Rno data
T114Asingle resistance variantno datano dataCRyPTIC-Rno data
P115Asingle resistance variantno datano dataCRyPTIC-Rno data
P115Rsingle resistance variantno datano dataCRyPTIC-Rno data
L116Psingle resistance variantno datano dataCRyPTIC-RWHO-R
L116Rsingle resistance variantPMID:10390239ReSeqTB-HighCRyPTIC-RWHO-R
L116Qsingle resistance variantno datano dataCRyPTIC-Rno data
L117fsframeshift mutationno dataReSeqTB-Highno datano data
L117Qsingle resistance variantno datano dataCRyPTIC-Rno data
N118Tsingle resistance variantPMID:10813147no datano datano data
N118Nsingle resistance variantno datano dataCRyPTIC-Rno data
N118Ysingle resistance variantno datano dataCRyPTIC-Rno data
W119Lsingle resistance variantno datano dataCRyPTIC-RWHO-R
W119Csingle resistance variantno datano datano dataWHO-R
W119Ternonsense mutationPMID:11641519no dataCRyPTIC-RWHO-R
W119Gsingle resistance variantno datano dataCRyPTIC-RWHO-R
W119Rsingle resistance variantPMID:9056006no dataCRyPTIC-RWHO-R
L120Rsingle resistance variantno datano datano dataWHO-R
L120Psingle resistance variantno datano dataCRyPTIC-RWHO-R
L120Qsingle resistance variantno datano dataCRyPTIC-RWHO-R
R121Psingle resistance variantPMID:10813147no datano dataWHO-R
Q122Ternonsense mutationPMID:31910878no dataCRyPTIC-RWHO-R
Q122Qsingle resistance variantno datano dataCRyPTIC-Rno data
Q122Ksingle resistance variantno datano dataCRyPTIC-Rno data
R123Ssingle resistance variantno datano dataCRyPTIC-Rno data
R123Psingle resistance variantno datano dataCRyPTIC-RWHO-U
G124Ssingle resistance variantno datano dataCRyPTIC-Rno data
V125Vsingle resistance variantno datano dataCRyPTIC-Rno data
V125Gsingle resistance variantno datano dataCRyPTIC-RWHO-R
V125Dsingle resistance variantPMID:10390239no dataCRyPTIC-Rno data
V125Asingle resistance variantno datano dataCRyPTIC-Rno data
V125Fsingle resistance variantno datano dataCRyPTIC-RWHO-R
E127Ternonsense mutationno datano dataCRyPTIC-Rno data
E127Dsingle resistance variantno datano dataCRyPTIC-Rno data
V128Gsingle resistance variantno dataReSeqTB-ModerateCRyPTIC-RWHO-R
V128Asingle resistance variantno datano dataCRyPTIC-Rno data
V128Dsingle resistance variantno datano dataCRyPTIC-Rno data
D129Nsingle resistance variantno datano dataCRyPTIC-SWHO-R
D129Esingle resistance variantno datano dataCRyPTIC-Rno data
V130Gsingle resistance variantno datano datano dataWHO-R
V130Esingle resistance variantno datano dataCRyPTIC-Rno data
V130Msingle resistance variantno datano datano dataWHO-R
V130G,+nt420:GGmultiple resistance variantsPMID:10681313no datano datano data
V131Dsingle resistance variantno datano dataCRyPTIC-Rno data
V131fsframeshift mutationno dataReSeqTB-Highno datano data
V131Isingle resistance variantno datano dataCRyPTIC-Rno data
V131Fsingle resistance variantno datano dataCRyPTIC-RWHO-R
V131Gsingle resistance variantno datano datano dataWHO-R
G132Rsingle resistance variantno datano dataCRyPTIC-Rno data
G132Ssingle resistance variantPMID:17596354no dataCRyPTIC-RWHO-R
G132Csingle resistance variantno datano dataCRyPTIC-RWHO-R
G132Dsingle resistance variantno datano dataCRyPTIC-RWHO-R
G132Asingle resistance variantno datano dataCRyPTIC-RWHO-R
G132Vsingle resistance variantno datano dataCRyPTIC-Rno data
I133Nsingle resistance variantno datano dataCRyPTIC-RWHO-U
I133Fsingle resistance variantno datano dataCRyPTIC-Rno data
I133Tsingle resistance variantPMID:17596354ReSeqTB-HighCRyPTIC-RWHO-R
A134Psingle resistance variantno datano dataCRyPTIC-RWHO-U
A134Vsingle resistance variantPMID:10681313no dataCRyPTIC-RWHO-R
T135Nsingle resistance variantno datano dataCRyPTIC-RWHO-R
T135Psingle resistance variantPMID:11641519ReSeqTB-HighCRyPTIC-RWHO-R
T135Isingle resistance variantno datano dataCRyPTIC-Rno data
T135Ssingle resistance variantno datano dataCRyPTIC-Rno data
D136Vsingle resistance variantno datano dataCRyPTIC-RWHO-R
D136Nsingle resistance variantPMID:11641519no dataCRyPTIC-Rno data
D136fsframeshift mutationno dataReSeqTB-Highno datano data
D136Hsingle resistance variantPMID:10471589no dataCRyPTIC-RWHO-U
D136Ysingle resistance variantPMID:17596354ReSeqTB-HighCRyPTIC-RWHO-U
D136Gsingle resistance variantno datano datano dataWHO-R
H137Psingle resistance variantPMID:10471589no dataCRyPTIC-RWHO-R
H137Rsingle resistance variantPMID:9056006no dataCRyPTIC-RWHO-S
H137Dsingle resistance variantno datano dataCRyPTIC-Rno data
C138Fsingle resistance variantno datano dataCRyPTIC-Rno data
C138Ssingle resistance variantPMID:10681313no dataCRyPTIC-RWHO-U
C138Wsingle resistance variantPMID:31910878no datano datano data
C138Ternonsense mutationno datano dataCRyPTIC-Rno data
C138Ysingle resistance variantPMID:10813147no dataCRyPTIC-Rno data
C138Rsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
C138Gsingle resistance variantno datano dataCRyPTIC-Rno data
V139Lsingle resistance variantPMID:10813147no dataCRyPTIC-RWHO-R
V139Esingle resistance variantno datano dataCRyPTIC-Rno data
V139Gsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
V139Msingle resistance variantPMID:10681313no dataCRyPTIC-RWHO-R
V139Asingle resistance variantPMID:10813147no dataCRyPTIC-RWHO-R
R140Psingle resistance variantno datano dataCRyPTIC-RWHO-R
R140Gsingle resistance variantPMID:31910878no datano datano data
R140Ssingle resistance variantPMID:10681313no datano datano data
Q141Ternonsense mutationPMID:11641519no dataCRyPTIC-RWHO-R
Q141Psingle resistance variantPMID:10681313ReSeqTB-HighCRyPTIC-RWHO-R
T142Ksingle resistance variantPMID:10813147no dataCRyPTIC-RWHO-R
T142Asingle resistance variantno datano dataCRyPTIC-RWHO-R
T142Msingle resistance variantPMID:10471589no dataCRyPTIC-RWHO-R
T142Tsingle resistance variantno datano dataCRyPTIC-Rno data
T142Psingle resistance variantno datano datano dataWHO-R
T142Rsingle resistance variantno datano dataCRyPTIC-Rno data
A143Dsingle resistance variantno datano dataCRyPTIC-Rno data
A143Gsingle resistance variantno datano datano dataWHO-R
E144Ternonsense mutationno datano dataCRyPTIC-RWHO-R
D145Esingle resistance variantno datano dataCRyPTIC-Rno data
A146Tsingle resistance variantPMID:11641519no dataCRyPTIC-SWHO-R
A146Vsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
A146Ssingle resistance variantno datano dataCRyPTIC-Rno data
A146Esingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
V147Asingle resistance variantno datano dataCRyPTIC-Rno data
N149Isingle resistance variantno datano dataCRyPTIC-Rno data
N149Ysingle resistance variantno datano dataCRyPTIC-Rno data
G150Gsingle resistance variantno datano dataCRyPTIC-Rno data
L151Ternonsense mutationno datano dataCRyPTIC-Rno data
L151Ssingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
-nt151:80deletion mutation from nucleotide sequencePMID:11641519no datano datano data
A152Vsingle resistance variantno datano dataCRyPTIC-Rno data
T153Nsingle resistance variantno datano dataCRyPTIC-Rno data
R154Msingle resistance variantno datano dataCRyPTIC-RWHO-R
R154Gsingle resistance variantPMID:10390239no datano dataWHO-R
R154Wsingle resistance variantPMID:31910878no datano datano data
V155Gsingle resistance variantPMID:10681313no dataCRyPTIC-RWHO-R
V155Msingle resistance variantno datano dataCRyPTIC-RWHO-R
V155Esingle resistance variantno datano dataCRyPTIC-Rno data
V155Asingle resistance variantno datano datano dataWHO-R
L156Psingle resistance variantno datano dataCRyPTIC-RWHO-U
L156Rsingle resistance variantno datano dataCRyPTIC-Rno data
V157Gsingle resistance variantPMID:31910878no datano dataWHO-U
D158Gsingle resistance variantno datano dataCRyPTIC-Rno data
-nt158:adeletion mutation from nucleotide sequencePMID:11641519no datano datano data
L159Vsingle resistance variantno datano dataCRyPTIC-RWHO-R
L159Psingle resistance variantno datano dataCRyPTIC-RWHO-R
L159Rsingle resistance variantPMID:11641519no datano dataWHO-R
L159Qsingle resistance variantno datano dataCRyPTIC-Rno data
T160Psingle resistance variantPMID:10390239no dataCRyPTIC-RWHO-R
T160Ksingle resistance variantno datano dataCRyPTIC-RWHO-R
T160Rsingle resistance variantno datano dataCRyPTIC-RWHO-U
A161Gsingle resistance variantPMID:31910878no datano datano data
A161Psingle resistance variantPMID:10390239no dataCRyPTIC-RWHO-U
-nt161:cdeletion mutation from nucleotide sequencePMID:11641519no datano datano data
G162Vsingle resistance variantno datano dataCRyPTIC-Rno data
G162Dsingle resistance variantno datano dataCRyPTIC-RWHO-R
G162Asingle resistance variantno datano dataCRyPTIC-Rno data
V163Asingle resistance variantno datano datano dataWHO-R
V163Esingle resistance variantno datano dataCRyPTIC-Rno data
S164Ssingle resistance variantno datano dataCRyPTIC-Rno data
S164Psingle resistance variantPMID:31910878no dataCRyPTIC-RWHO-R
S164Ternonsense mutationno dataReSeqTB-HighCRyPTIC-RWHO-R
S164Tsingle resistance variantno datano dataCRyPTIC-Rno data
A165Dsingle resistance variantno datano dataCRyPTIC-Rno data
D166Vsingle resistance variantno datano dataCRyPTIC-Rno data
T168Psingle resistance variantno datano dataCRyPTIC-RWHO-R
T168Nsingle resistance variantPMID:10681313no datano datano data
A170Ssingle resistance variantno datano dataCRyPTIC-Rno data
A170Vsingle resistance variantno datano dataCRyPTIC-Rno data
A171Asingle resistance variantno datano dataCRyPTIC-Rno data
A171Tsingle resistance variantPMID:10471589no dataCRyPTIC-RWHO-U
A171Esingle resistance variantno datano dataCRyPTIC-RWHO-R
A171Vsingle resistance variantPMID:10471589no datano datano data
A171Psingle resistance variantPMID:9055989no datano dataWHO-R
L172Asingle resistance variantPMID:10471589no datano datano data
L172Psingle resistance variantPMID:31910878no dataCRyPTIC-RWHO-R
E173Ternonsense mutationno datano dataCRyPTIC-RWHO-R
E173Gsingle resistance variantno datano dataCRyPTIC-Rno data
E174Gsingle resistance variantPMID:31910878no dataCRyPTIC-Rno data
E174Ksingle resistance variantno datano dataCRyPTIC-Rno data
E174Ternonsense mutationno datano datano dataWHO-R
M175Isingle resistance variantno datano dataCRyPTIC-RWHO-R
M175Rsingle resistance variantno datano datano dataWHO-R
M175Tsingle resistance variantno datano dataCRyPTIC-RWHO-R
M175Vsingle resistance variantPMID:17596354ReSeqTB-HighCRyPTIC-RWHO-R
M175Ksingle resistance variantno datano dataCRyPTIC-Rno data
R176Psingle resistance variantno datano dataCRyPTIC-Rno data
T177Tsingle resistance variantno datano dataCRyPTIC-Rno data
T177Psingle resistance variantno datano datano dataWHO-R
S179Nsingle resistance variantno datano dataCRyPTIC-Rno data
V180Asingle resistance variantno dataReSeqTB-Highno dataWHO-R
V180Gsingle resistance variantno dataReSeqTB-HighCRyPTIC-RWHO-R
V180Dsingle resistance variantno datano dataCRyPTIC-RWHO-U
V180Fsingle resistance variantPMID:11641519ReSeqTB-HighCRyPTIC-RWHO-R
E181Ternonsense mutationno datano dataCRyPTIC-RWHO-R
E181Ksingle resistance variantno datano dataCRyPTIC-Rno data
L182Ssingle resistance variantPMID:31910878ReSeqTB-HighCRyPTIC-SWHO-R
L182Wsingle resistance variantno datano datano dataWHO-R
V183Vsingle resistance variantno datano dataCRyPTIC-Rno data
V183Dsingle resistance variantno datano dataCRyPTIC-Rno data
C184Rsingle resistance variantno datano dataCRyPTIC-Rno data
S186Fsingle resistance variantno datano dataCRyPTIC-Rno data
+nt193:ainsertion mutation from nucleotide sequencePMID:10681313no datano datano data
-nt195:68deletion mutation from nucleotide sequencePMID:10471589no datano datano data
+nt218:cgcattgccginsertion mutation from nucleotide sequencePMID:17596354no datano datano data
+nt221:ginsertion mutation from nucleotide sequencePMID:10471589no datano datano data
-nt267:24deletion mutation from nucleotide sequencecuration underwayno datano datano data
+nt287:tinsertion mutation from nucleotide sequencePMID:11641519no datano datano data
-nt301:gdeletion mutation from nucleotide sequencePMID:10681313no datano datano data
-nt307:tacagdeletion mutation from nucleotide sequencePMID:11641519no datano datano data
-nt341:cdeletion mutation from nucleotide sequencePMID:10681313no datano datano data
+nt368:18insertion mutation from nucleotide sequencePMID:11641519no datano datano data
-nt379:11deletion mutation from nucleotide sequencecuration underwayno datano datano data
-nt381:ggdeletion mutation from nucleotide sequencecuration underwayno datano datano data
+nt382:aginsertion mutation from nucleotide sequencePMID:11429043no datano datano data
-nt386:atgtdeletion mutation from nucleotide sequencecuration underwayno datano datano data
-nt386:atgdeletion mutation from nucleotide sequencePMID:17596354no datano datano data
+nt388:aggtcgatginsertion mutation from nucleotide sequencePMID:9056006no datano datano data
-nt391:gdeletion mutation from nucleotide sequencePMID:9055989no datano datano data
+nt391:gginsertion mutation from nucleotide sequencePMID:10390238no datano datano data
+nt392:ginsertion mutation from nucleotide sequencePMID:25336456no datano datano data
+nt397:tinsertion mutation from nucleotide sequencePMID:9056006no datano datano data
+nt403:cinsertion mutation from nucleotide sequencePMID:11429043no datano datano data
-nt406:gdeletion mutation from nucleotide sequencecuration underwayno datano datano data
+nt407:cinsertion mutation from nucleotide sequencePMID:11429043no datano datano data
+nt414:ginsertion mutation from nucleotide sequencePMID:11641519no datano datano data
-nt416:tgdeletion mutation from nucleotide sequencePMID:11429043no datano datano data
+nt420:ginsertion mutation from nucleotide sequencePMID:10681313no datano datano data
-nt443:gdeletion mutation from nucleotide sequencePMID:9055989no datano datano data
-nt446:8deletion mutation from nucleotide sequencePMID:9055989no datano datano data
-nt452:tdeletion mutation from nucleotide sequencecuration underwayno datano datano data
+nt465:tinsertion mutation from nucleotide sequencePMID:11641519no datano datano data
+nt475:cinsertion mutation from nucleotide sequencePMID:9055989no datano datano data
+nt480:tgacinsertion mutation from nucleotide sequencePMID:11641519no datano datano data
+nt493:cinsertion mutation from nucleotide sequencePMID:17596354no datano datano data
-nt512:cdeletion mutation from nucleotide sequencePMID:10471589no datano datano data
-nt518:5deletion mutation from nucleotide sequencecuration underwayno datano datano data
+nt532:cinsertion mutation from nucleotide sequencePMID:11641519no datano datano data

>gb|NP_216559.1|-|Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide [Mycobacterium tuberculosis H37Rv]
MRALIIVDVQNDFCEGGSLAVTGGAALARAISDYLAEAADYHHVVATKDFHIDPGDHFSG
TPDYSSSWPPHCVSGTPGADFHPSLDTSAIEAVFYKGAYTGAYSGFEGVDENGTPLLNWL
RQRGVDEVDVVGIATDHCVRQTAEDAVRNGLATRVLVDLTAGVSADTTVAALEEMRTASV
ELVCSS



>gb|NC_000962.3|-|2288681-2289241|Mycobacterium tuberculosis pncA mutations conferring resistance to pyrazinamide [Mycobacterium tuberculosis H37Rv]
ATGCGGGCGTTGATCATCGTCGACGTGCAGAACGACTTCTGCGAGGGTGGCTCGCTGGCGGTAACCGGTGGCGCCGCGCTGGCCCGCGCC
ATCAGCGACTACCTGGCCGAAGCGGCGGACTACCATCACGTCGTGGCAACCAAGGACTTCCACATCGACCCGGGTGACCACTTCTCCGGC
ACACCGGACTATTCCTCGTCGTGGCCACCGCATTGCGTCAGCGGTACTCCCGGCGCGGACTTCCATCCCAGTCTGGACACGTCGGCAATC
GAGGCGGTGTTCTACAAGGGTGCCTACACCGGAGCGTACAGCGGCTTCGAAGGAGTCGACGAGAACGGCACGCCACTGCTGAATTGGCTG
CGGCAACGCGGCGTCGATGAGGTCGATGTGGTCGGTATTGCCACCGATCATTGTGTGCGCCAGACGGCCGAGGACGCGGTACGCAATGGC
TTGGCCACCAGGGTGCTGGTGGACCTGACAGCGGGTGTGTCGGCCGATACCACCGTCGCCGCGCTGGAGGAGATGCGCACCGCCAGCGTC
GAGTTGGTTTGCAGCTCCTGA

Curator Acknowledgements
Curator Description Most Recent Edit