| Accession | ARO:3005098 |
| CARD Short Name | qacL |
| Definition | A subunit of the qac multidrug efflux pump in Vibrio cholerae. |
| AMR Gene Family | small multidrug resistance (SMR) antibiotic efflux pump |
| Drug Class | disinfecting agents and antiseptics |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Perfect Matches | Pseudomonas aeruginosap+wgs |
| Resistomes with Sequence Variants | Achromobacter xylosoxidanswgs, Acinetobacter indicusp, Aeromonas hydrophilap+wgs, Aeromonas veroniig+wgs, Burkholderia cenocepaciag+wgs, Burkholderia cepaciawgs, Burkholderia vietnamiensiswgs, Citrobacter amalonaticuswgs, Citrobacter freundiiwgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Citrobacter youngaewgs, Enterobacter asburiaewgs, Enterobacter cloacaewgs, Enterobacter hormaecheip+wgs, Enterobacter kobeiwgs, Escherichia albertiiwgs, Escherichia colig+p+wgs, Escherichia fergusoniip+wgs, Klebsiella aerogeneswgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocap+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Laribacter hongkongensisg+wgs, Morganella morganiig+wgs, Pasteurella multocidag, Proteus mirabilisg+p+wgs, Providencia rettgeriwgs, Providencia stuartiip, Pseudomonas aeruginosap+wgs, Pseudomonas putidag+wgs, Salmonella entericag+p+wgs, Serratia marcescenswgs, Shigella boydiiwgs, Shigella dysenteriaeg, Shigella flexnerig+p, Shigella sonneiwgs, Vibrio choleraewgs, Vibrio parahaemolyticuswgs, Yersinia enterocoliticawgs |
| Classification | 6 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + antibiotic molecule |
| Parent Term(s) | 2 ontology terms | Show + small multidrug resistance (SMR) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_drug_class disinfecting agents and antiseptics [Drug Class] |
| Publications | Ceccarelli D, et al. 2006. Antimicrob. Agents Chemother. 50(7):2493-9 New cluster of plasmid-located class 1 integrons in Vibrio cholerae O1 and a dfrA15 cassette-containing integron in Vibrio parahaemolyticus isolated in Angola. (PMID 16801431) |
Prevalence of qacL among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Achromobacter xylosoxidans | 0% | 0% | 0.76% | 0% |
| Acinetobacter indicus | 0% | 1.89% | 0% | 0% |
| Aeromonas hydrophila | 0% | 2.6% | 0.81% | 0% |
| Aeromonas veronii | 3.64% | 0% | 0.56% | 0% |
| Burkholderia cenocepacia | 0.5% | 0% | 3.07% | 0% |
| Burkholderia cepacia | 0% | 0% | 7.17% | 0% |
| Burkholderia vietnamiensis | 0% | 0% | 0.86% | 0% |
| Citrobacter amalonaticus | 0% | 0% | 3.64% | 0% |
| Citrobacter freundii | 0% | 0% | 1.16% | 0% |
| Citrobacter portucalensis | 0% | 0% | 0.9% | 0% |
| Citrobacter werkmanii | 0% | 0% | 2.56% | 0% |
| Citrobacter youngae | 0% | 0% | 12.5% | 0% |
| Enterobacter asburiae | 0% | 0% | 0.4% | 0% |
| Enterobacter cloacae | 0% | 0% | 1.6% | 0% |
| Enterobacter hormaechei | 0% | 0.19% | 1.68% | 0% |
| Enterobacter kobei | 0% | 0% | 0.44% | 0% |
| Escherichia albertii | 0% | 0% | 1.94% | 0% |
| Escherichia coli | 0.4% | 1.31% | 4.27% | 0% |
| Escherichia fergusonii | 0% | 4.27% | 7.61% | 0% |
| Klebsiella aerogenes | 0% | 0% | 0.56% | 0% |
| Klebsiella michiganensis | 0% | 1.71% | 1.06% | 0% |
| Klebsiella oxytoca | 0% | 1.37% | 0.84% | 0% |
| Klebsiella pneumoniae | 0.65% | 0.93% | 3.07% | 0% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 1.97% | 0% |
| Laribacter hongkongensis | 66.67% | 0% | 2.08% | 0% |
| Morganella morganii | 1.92% | 0% | 1.23% | 0% |
| Pasteurella multocida | 0.71% | 0% | 0% | 0% |
| Proteus mirabilis | 7.34% | 1.25% | 2.64% | 0% |
| Providencia rettgeri | 0% | 0% | 2.55% | 0% |
| Providencia stuartii | 0% | 2.27% | 0% | 0% |
| Pseudomonas aeruginosa | 0% | 2.05% | 1.28% | 0% |
| Pseudomonas putida | 1.41% | 0% | 1.07% | 0% |
| Salmonella enterica | 1.2% | 4.65% | 1.25% | 0% |
| Serratia marcescens | 0% | 0% | 0.52% | 0% |
| Shigella boydii | 0% | 0% | 4.44% | 0% |
| Shigella dysenteriae | 14.29% | 0% | 0% | 0% |
| Shigella flexneri | 1% | 3.61% | 0% | 0% |
| Shigella sonnei | 0% | 0% | 0.58% | 0% |
| Vibrio cholerae | 0% | 0% | 0.06% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.1% | 0% |
| Yersinia enterocolitica | 0% | 0% | 0.91% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 180