| Accession | ARO:3007012 |
| CARD Short Name | sepA |
| Definition | sepA is a multidrug efflux pump that confers resistance to disinfecting agents and dyes. |
| AMR Gene Family | small multidrug resistance (SMR) antibiotic efflux pump |
| Drug Class | disinfecting agents and antiseptics |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes with Sequence Variants | Macrococcus canisg+wgs, Staphylococcus arlettaeg+wgs, Staphylococcus aureusg+wgs, Staphylococcus capitisg+wgs, Staphylococcus epidermidisg+wgs, Staphylococcus equorumg+wgs, Staphylococcus haemolyticusg+wgs, Staphylococcus hominisg+wgs, Staphylococcus intermediuswgs, Staphylococcus lugdunensisg+p+wgs, Staphylococcus massiliensiswgs, Staphylococcus pasteurig+wgs, Staphylococcus pseudintermediusg+wgs, Staphylococcus saprophyticusg+wgs, Staphylococcus schleiferig+wgs, Staphylococcus simulansg+wgs, Staphylococcus warnerig+wgs |
| Classification | 7 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + disinfecting agents and antiseptics [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_drug_class disinfecting agents and antiseptics [Drug Class] + small multidrug resistance (SMR) antibiotic efflux pump [AMR Gene Family] + confers_resistance_to_antibiotic acriflavine [Antibiotic] |
| Publications | Narui K, et al. 2002. Biol Pharm Bull 25(12):1533-6 Cloning and characterization of a novel chromosomal drug efflux gene in Staphylococcus aureus. (PMID 12499635) |
Prevalence of sepA among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Escherichia coli | 0% | 0% | 0% | 0% |
| Macrococcus canis | 100% | 0% | 100% | 0% |
| Staphylococcus arlettae | 100% | 0% | 80% | 0% |
| Staphylococcus aureus | 99.56% | 0% | 56.12% | 0% |
| Staphylococcus capitis | 100% | 0% | 68.99% | 0% |
| Staphylococcus epidermidis | 100% | 0% | 72.22% | 0% |
| Staphylococcus equorum | 100% | 0% | 82.14% | 0% |
| Staphylococcus haemolyticus | 96.55% | 0% | 61.76% | 0% |
| Staphylococcus hominis | 100% | 0% | 66.34% | 0% |
| Staphylococcus intermedius | 0% | 0% | 100% | 0% |
| Staphylococcus lugdunensis | 100% | 1.79% | 26.15% | 0% |
| Staphylococcus massiliensis | 0% | 0% | 57.14% | 0% |
| Staphylococcus pasteuri | 100% | 0% | 100% | 0% |
| Staphylococcus pseudintermedius | 100% | 0% | 73.08% | 0% |
| Staphylococcus saprophyticus | 100% | 0% | 73.43% | 0% |
| Staphylococcus schleiferi | 100% | 0% | 40.91% | 0% |
| Staphylococcus simulans | 100% | 0% | 98.31% | 0% |
| Staphylococcus warneri | 100% | 0% | 75.41% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 100