qacG

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Accession ARO:3007015
CARD Short NameqacG
DefinitionqacG is a small multidrug resistance efflux pump that confers resistance to benzalkonium chloride and ethidium bromide.
AMR Gene Familysmall multidrug resistance (SMR) antibiotic efflux pump
Drug Classdisinfecting agents and antiseptics
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Resistomes with Perfect MatchesStaphylococcus aureusp+wgs, Staphylococcus epidermidiswgs, Staphylococcus equorump+wgs, Staphylococcus pseudintermediuswgs, Staphylococcus saprophyticuswgs, Staphylococcus warneriwgs
Resistomes with Sequence VariantsAchromobacter insolitusg+wgs, Achromobacter xylosoxidansg+wgs, Acinetobacter baumanniig+p+wgs, Acinetobacter defluviip+wgs, Acinetobacter haemolyticusg+wgs, Acinetobacter indicusp+wgs, Acinetobacter johnsoniig+wgs, Acinetobacter juniig+p+wgs, Acinetobacter lwoffiig+wgs, Acinetobacter nosocomialisp+wgs, Acinetobacter pittiiwgs, Acinetobacter radioresistenswgs, Acinetobacter towneriwgs, Acinetobacter wuhouensisg+p+wgs, Actinobacillus indolicusg+wgs, Actinobacillus pleuropneumoniaeg+wgs, Actinobacillus porcitonsillarumg, Aeromonas caviaewgs, Aeromonas hydrophilag+wgs, Aggregatibacter actinomycetemcomitansg+wgs, Alcaligenes faecalisg+wgs, Alistipes putrediniswgs, Avibacterium paragallinarumg, Bacillus amyloliquefaciensg+wgs, Bacillus cereuswgs, Bacillus halotoleransg+wgs, Bacillus pumilusg+wgs, Bacillus subtilisg+wgs, Bacillus tequilensisg+wgs, Bacillus velezensisg+wgs, Bacteroides fragiliswgs, Bacteroides ovatuswgs, Bacteroides thetaiotaomicronwgs, Bordetella bronchisepticag+wgs, Bordetella hinziig+wgs, Bordetella holmesiig+wgs, Bordetella parapertussisg+wgs, Bordetella pertussisg+wgs, Bordetella petriiwgs, Bordetella trematumg+wgs, Brevibacillus brevisg+wgs, Brucella abortusg+wgs, Brucella canisg+wgs, Brucella inopinatag+wgs, Brucella intermediag+wgs, Brucella melitensisg+wgs, Brucella ovisg+wgs, Brucella suisg+wgs, Burkholderia ambifariag+wgs, Burkholderia cenocepaciag+wgs, Burkholderia cepaciag+wgs, Burkholderia contaminansg+wgs, Burkholderia dolosag+wgs, Burkholderia glumaeg+wgs, Burkholderia latag+wgs, Burkholderia malleig+wgs, Burkholderia multivoransg+wgs, Burkholderia pseudomalleig+wgs, Burkholderia vietnamiensisg+p+wgs, Capnocytophaga gingivalisg+wgs, Capnocytophaga ochraceag+wgs, Capnocytophaga sputigenag+wgs, Chryseobacterium nakagawaig+wgs, Citrobacter freundiiwgs, Citrobacter portucalensisg+wgs, Clostridium butyricumg+wgs, Collinsella aerofacienswgs, Comamonas testosteroniwgs, Cronobacter dublinensisg+wgs, Cronobacter malonaticusg+wgs, Cronobacter sakazakiig+wgs, Cronobacter turicensiswgs, Cronobacter universalisg+wgs, Delftia tsuruhatensisg+wgs, Edwardsiella tardag+wgs, Elizabethkingia anophelisg+wgs, Elizabethkingia miricolag+wgs, Enterobacter asburiaewgs, Enterobacter cancerogenusp, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeig+wgs, Enterobacter roggenkampiiwgs, Enterococcus faecaliswgs, Enterococcus faeciumwgs, Escherichia colip+wgs, Glaesserella parasuiswgs, Haemophilus influenzaewgs, Haemophilus parainfluenzaeg+wgs, Histophilus somnig+wgs, Klebsiella aerogenesg+wgs, Klebsiella michiganensiswgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+p+wgs, Kosakonia arachidisg+wgs, Moraxella osloensisg+wgs, Morganella morganiig+wgs, Mycobacterium aviumg+wgs, Mycobacterium colombiensewgs, Mycobacterium intracellulareg+wgs, Mycobacterium kansasiig+wgs, Mycobacterium tuberculosisg+wgs, Myroides odoratimimusg+wgs, Myroides phaeusg+wgs, Neisseria meningitidisg+wgs, Neisseria siccawgs, Nocardia terpenicag, Parabacteroides distasoniswgs, Paracoccus denitrificansg+wgs, Paracoccus kondratievaeg+wgs, Pasteurella multocidag, Phocaeicola doreiwgs, Phocaeicola massiliensiswgs, Phocaeicola vulgatuswgs, Proteus columbaeg, Proteus mirabilisg+wgs, Proteus vulgarisg+wgs, Providencia heimbachaeg+wgs, Providencia rettgerig+p+wgs, Providencia stuartiig+wgs, Pseudomonas aeruginosap+wgs, Pseudomonas fluorescenswgs, Pseudomonas mendocinag+wgs, Pseudomonas putidawgs, Pseudomonas stutzerig+wgs, Ralstonia solanacearump, Raoultella planticolap, Rhizobium leguminosarumg+wgs, Rhodanobacter glycinisg+wgs, Rhodopseudomonas palustrisg+wgs, Salmonella entericag+wgs, Serratia liquefaciensg+wgs, Serratia marcescensg+p+wgs, Serratia odoriferag+wgs, Serratia rubidaeag+wgs, Shigella sonneiwgs, Sphingobium yanoikuyaeg+wgs, Staphylococcus arlettaeg+wgs, Staphylococcus aureusp+wgs, Staphylococcus capitiswgs, Staphylococcus epidermidiswgs, Staphylococcus equorump+wgs, Staphylococcus haemolyticuswgs, Staphylococcus pseudintermediusg+p+wgs, Staphylococcus saprophyticusp+wgs, Staphylococcus warneriwgs, Stenotrophomonas maltophiliag+wgs, Streptococcus agalactiaewgs, Streptococcus cristatuswgs, Streptococcus gallolyticusg+wgs, Streptococcus gordoniig+wgs, Streptococcus mitiswgs, Streptococcus sanguinisg+wgs, Vibrio alginolyticusg+wgs, Vibrio choleraeg+wgs, Vibrio fluvialiswgs, Vibrio harveyig+wgs, Vibrio neocaledonicusg, Vibrio owensiig+wgs, Vibrio parahaemolyticuswgs, Xanthomonas campestrisg+wgs, Yersinia enterocoliticag, Yersinia pestisg+wgs, Yersinia pseudotuberculosisg+wgs
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ small multidrug resistance (SMR) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic benzalkonium chloride [Antibiotic]
Publications

Heir E, et al. 1999. J Appl Microbiol 86(3):378-88 The qacG gene on plasmid pST94 confers resistance to quaternary ammonium compounds in staphylococci isolated from the food industry. (PMID 10196743)
Resistomes

Prevalence of qacG among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 414 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GIGRDI-AMR2
Achromobacter insolitus100%0%100%0%0%
Achromobacter xylosoxidans100%0%97.71%0%0%
Acinetobacter baumannii0.35%0.21%1.1%0%0%
Acinetobacter defluvii0%12.5%100%0%0%
Acinetobacter haemolyticus100%0%100%0%0%
Acinetobacter indicus0%1.89%1.3%0%0%
Acinetobacter johnsonii36.84%0%18.18%0%0%
Acinetobacter junii63.64%16.67%88.06%0%0%
Acinetobacter lwoffii27.27%0%34.21%0%0%
Acinetobacter nosocomialis0%1.64%6.9%0%0%
Acinetobacter pittii0%0%5.97%0%0%
Acinetobacter radioresistens0%0%17.54%0%0%
Acinetobacter towneri0%0%3.85%0%0%
Acinetobacter wuhouensis50%13.64%100%0%0%
Actinobacillus indolicus100%0%100%0%0%
Actinobacillus pleuropneumoniae100%0%100%0%0%
Actinobacillus porcitonsillarum100%0%0%0%0%
Aeromonas caviae0%0%9.14%0%0%
Aeromonas hydrophila1.54%0%4.84%0%0%
Aggregatibacter actinomycetemcomitans36%0%42.04%0%0%
Alcaligenes faecalis95%0%100%0%0%
Alistipes putredinis0%0%2%0%0%
Avibacterium paragallinarum6.25%0%0%0%0%
Bacillus amyloliquefaciens81.43%0%78.65%0%0%
Bacillus cereus0%0%0.3%0%0%
Bacillus halotolerans100%0%100%0%0%
Bacillus pumilus100%0%98.32%0%0%
Bacillus subtilis98.92%0%98.27%0%0%
Bacillus tequilensis100%0%100%0%0%
Bacillus velezensis93.31%0%90.11%0%0%
Bacteroides fragilis0%0%0.27%0%0%
Bacteroides ovatus0%0%2.66%0%0%
Bacteroides thetaiotaomicron0%0%3.15%0%0%
Bordetella bronchiseptica100%0%98.63%0%0%
Bordetella hinzii100%0%100%0%0%
Bordetella holmesii100%0%100%0%0%
Bordetella parapertussis100%0%100%0%0%
Bordetella pertussis100%0%99.3%0%0%
Bordetella petrii0%0%16.67%0%0%
Bordetella trematum100%0%100%0%0%
Brevibacillus brevis71.43%0%90%0%0%
Brucella abortus49.21%0%96%0%0%
Brucella canis50%0%100%0%0%
Brucella inopinata50%0%100%0%0%
Brucella intermedia50%0%97.3%0%0%
Brucella melitensis50.24%0%99.68%0%0%
Brucella ovis50%0%100%0%0%
Brucella suis50%0%95.83%0%0%
Burkholderia ambifaria34.88%0%100%0%0%
Burkholderia cenocepacia34.17%0%99.56%0%0%
Burkholderia cepacia38.18%0%99.55%0%0%
Burkholderia contaminans32.65%0%98.75%0%0%
Burkholderia dolosa33.33%0%100%0%0%
Burkholderia glumae51%0%100%0%0%
Burkholderia lata33.33%0%100%0%0%
Burkholderia mallei50.85%0%92.86%0%0%
Burkholderia multivorans33.97%0%100%0%0%
Burkholderia pseudomallei49.83%0%99.22%0%0%
Burkholderia vietnamiensis34.38%9.09%99.14%0%0%
Capnocytophaga gingivalis100%0%50%0%0%
Capnocytophaga ochracea66.67%0%42.86%0%0%
Capnocytophaga sputigena75%0%33.33%0%0%
Chryseobacterium nakagawai100%0%100%0%0%
Citrobacter freundii0%0%1.35%0%0%
Citrobacter portucalensis3.7%0%9.91%0%0%
Clostridium butyricum4.17%0%7.84%0%0%
Collinsella aerofaciens0%0%3.73%0%0%
Comamonas testosteroni0%0%14.29%0%0%
Cronobacter dublinensis100%0%97.44%0%0%
Cronobacter malonaticus100%0%98.18%0%0%
Cronobacter sakazakii88.89%0%93.95%0%0%
Cronobacter turicensis0%0%100%0%0%
Cronobacter universalis100%0%100%0%0%
Delftia tsuruhatensis100%0%100%0%0%
Edwardsiella tarda100%0%93.33%0%0%
Elizabethkingia anophelis100%0%98.97%0%0%
Elizabethkingia miricola100%0%100%0%0%
Enterobacter asburiae0%0%0.79%0%0%
Enterobacter cancerogenus0%25%0%0%0%
Enterobacter chengduensis0%0%8%0%0%
Enterobacter cloacae12.5%1.12%21.41%0%0%
Enterobacter hormaechei0%0.39%1.51%0%0%
Enterobacter kobei4.55%0%4.8%0%0%
Enterobacter roggenkampii0%0%0.72%0%0%
Enterococcus faecalis0%0%0.04%0%0%
Enterococcus faecium0%0%0.03%0%0%
Escherichia coli0%0.04%0.54%0%0.04%
Glaesserella parasuis0%0%0.51%0%0%
Haemophilus influenzae0%0%0.67%0%0%
Haemophilus parainfluenzae93.75%0%95.12%0%0%
Histophilus somni3.33%0%44.83%0%0%
Klebsiella aerogenes98%0%101.41%0%0%
Klebsiella michiganensis0%0%0.27%0%0%
Klebsiella pneumoniae10.12%0.06%12%0%0%
Klebsiella quasipneumoniae65.55%0.64%76.18%0%0%
Kosakonia arachidis100%0%100%0%0%
Moraxella osloensis70%0%78.57%0%0%
Morganella morganii88.46%0%89.57%0%0%
Mycobacterium avium80.49%0%79.43%0%0%
Mycobacterium colombiense0%0%5%0%0%
Mycobacterium intracellulare95.12%0%93.88%0%0%
Mycobacterium kansasii81.82%0%100%0%0%
Mycobacterium tuberculosis99.8%0%98.82%0%0%
Myroides odoratimimus100%0%121.43%0%0%
Myroides phaeus100%0%100%0%0%
Neisseria meningitidis11.45%0%16.89%0%0%
Neisseria sicca0%0%38.46%0%0%
Nocardia terpenica50%0%0%0%0%
Parabacteroides distasonis0%0%1.4%0%0%
Paracoccus denitrificans50%0%100%0%0%
Paracoccus kondratievae50%0%100%0%0%
Pasteurella multocida1.43%0%0%0%0%
Phocaeicola dorei0%0%1.04%0%0%
Phocaeicola massiliensis0%0%7.69%0%0%
Phocaeicola vulgatus0%0%5.85%0%0%
Proteus columbae100%0%0%0%0%
Proteus mirabilis0.92%0%0.33%0%0%
Proteus vulgaris54.55%0%77.78%0%0%
Providencia heimbachae100%0%100%0%0%
Providencia rettgeri88.24%2.7%96.18%0%0%
Providencia stuartii75%0%79.55%0%0%
Pseudomonas aeruginosa0%0.58%0.67%0%0%
Pseudomonas fluorescens0%0%0.87%0%0%
Pseudomonas mendocina100%0%100%0%0%
Pseudomonas putida0%0%0.53%0%0%
Pseudomonas stutzeri75%0%70.23%0%0%
Ralstonia solanacearum0%2.45%0%0%0%
Raoultella planticola0%2.33%0%0%0%
Rhizobium leguminosarum100%0%98.79%0%0%
Rhodanobacter glycinis100%0%33.33%0%0%
Rhodopseudomonas palustris30.77%0%11.11%0%0%
Salmonella enterica0.13%0%0.59%0%0%
Serratia liquefaciens100%0%100%0%0%
Serratia marcescens96.97%1.29%97.51%0%0%
Serratia odorifera100%0%100%0%0%
Serratia rubidaea100%0%100%0%0%
Shigella sonnei0%0%0.15%0%0%
Sphingobium yanoikuyae14.29%0%5.88%0%0%
Staphylococcus arlettae100%0%100%0%0%
Staphylococcus aureus0%1.64%0.59%0%0%
Staphylococcus capitis0%0%0.63%0%0%
Staphylococcus epidermidis0%0%0.42%0%0%
Staphylococcus equorum0%5.41%8.93%0%0%
Staphylococcus haemolyticus0%0%0.66%0%0%
Staphylococcus pseudintermedius1.67%20%10.51%0%0%
Staphylococcus saprophyticus0%2.7%15.38%0%0%
Staphylococcus warneri0%0%0.82%0%0%
Stenotrophomonas maltophilia24.72%0%40.36%0%0%
Streptococcus agalactiae0%0%0.13%0%0%
Streptococcus cristatus0%0%5.71%0%0%
Streptococcus gallolyticus80%0%84.09%0%0%
Streptococcus gordonii57.14%0%57.69%0%0%
Streptococcus mitis0%0%1.52%0%0%
Streptococcus sanguinis57.14%0%83.51%0%0%
Vibrio alginolyticus49.38%0%99.6%0%0%
Vibrio cholerae0.9%0%0.7%0%0%
Vibrio fluvialis0%0%2.67%0%0%
Vibrio harveyi50%0%86%0%0%
Vibrio neocaledonicus50%0%0%0%0%
Vibrio owensii50%0%94.74%0%0%
Vibrio parahaemolyticus0%0%0.62%0%0%
Xanthomonas campestris36.17%0%45.24%0%0%
Yersinia enterocolitica2.63%0%0%0%0%
Yersinia pestis100%0%97.46%0%0%
Yersinia pseudotuberculosis100%0%98.53%0%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 75


>gb|WP_015740450.1|+|qacG [Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance]
MHYLYLFISIATEIIGTSFLKTSEGFTKLWPTLGTLLSFGICFYFLSLTIKFLPLNITYATWAGLGLVLTTIISVIVFKENVNLISIISI
GLIVIGVVLLNVFGESH


>gb|NG_051904.1|+|101-424|qacG [Bacteria, Viruses, Fungi, and other genome sequence associated with antimicrobial resistance]
ATGCATTATTTATATTTATTTATCTCAATTGCAACAGAAATAATCGGAACTAGTTTTTTAAAAACATCAGAAGGTTTCACAAAGTTATGG
CCAACATTAGGTACACTACTTTCGTTTGGAATTTGCTTTTATTTTTTAAGTTTAACAATAAAATTTTTGCCCTTAAATATAACTTACGCA
ACATGGGCAGGTCTAGGATTAGTATTAACAACAATAATCTCAGTTATCGTTTTTAAAGAAAATGTTAATTTAATTAGTATAATTTCTATT
GGCTTAATTGTTATAGGTGTAGTGCTCTTAAATGTATTTGGAGAAAGCCATTGA

Curator Acknowledgements
Curator Description Most Recent Edit