Ontology | CARD's Antibiotic Resistance Ontology |
Accession | ARO:3007517 |
Definition | Ketoconazole is a type of imidazole antibiotic, particularly antifungal. It was one of the first available oral broad-spectrum antifungals for the treatment of systemic and superficial mycoses. |
SMILES | CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 |
PubChem | 456201 |
ChEBI | 47519 |
CAS | 65277-42-1 |
ChEMBL | CHEMBL157101 |
Drug Class | imidazole antibiotic |
Classification | 3 ontology terms | Show |
Parent Term(s) | 1 ontology terms | Show + imidazole antibiotic [Drug Class] |
Sub-Term(s) | 1 ontology terms | Show + Candida spp. cyp51A1 with mutations conferring resistance to triazoles and imidazole antibiotics confers_resistance_to_antibiotic |
Publications | Levine HB, et al. 1978. Am Rev Respir Dis 118(4):715-21 Oral therapy for experimental coccidioidomycosis with R41 400 (ketoconazole), a new imidazole. (PMID 707893) Heel RC, et al. 1982. Drugs 23(1-2):1-36 Ketoconazole: a review of its therapeutic efficacy in superficial and systemic fungal infections. (PMID 6276122) |
Curator | Description | Most Recent Edit |
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