Cryptococcus spp. AFR1

Accession ARO:3007566
DefinitionCryptococcus spp. AFR1 gene is an ABC transporter gene that contributes to antifungal resistance through antibiotic efflux.
AMR Gene FamilyATP-binding cassette (ABC) antibiotic efflux pump
Drug Classtriazole antibiotic
Resistance Mechanismantibiotic efflux
Efflux Componentefflux pump complex or subunit conferring antibiotic resistance
Classification8 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ ATP-binding cassette (ABC) antibiotic efflux pump [AMR Gene Family]
+ confers_resistance_to_antibiotic fluconazole [Antibiotic]

Posteraro B, et al. 2003. Mol Microbiol 47(2):357-71 Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole. (PMID 12519188)