Candida spp. High Osmolarity Glycerol 1 conferring resistance to caspofungin via absence

Accession ARO:3007664
DefinitionHog1 is a stress-activated protein kinase. Deletion of Hog1 confers resistance to caspofungin through increase in exposed chitin levels in the cell wall.
AMR Gene Familystress-activated protein kinases
Drug Classechinocandin antibiotic
Resistance Mechanismresistance by absence
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ stress-activated protein kinases [AMR Gene Family]
+ confers_resistance_to_antibiotic caspofungin [Antibiotic]

Day AM, et al. 2018. mSphere 3(5): Hog1 Regulates Stress Tolerance and Virulence in the Emerging Fungal Pathogen Candida auris. (PMID 30355673)