Serine/threonine kinases [AMR Gene Family]

Accession ARO:3007683
Synonym(s)ser/thr kineases STK
DefinitionThe eukaryotic-type Ser/Thr kinase (STKs) IreK (intrinsic resistance of enterococci kinase) belongs to a family of transmembrane kinases defined by the presence of multiple extracellular PASTA (penicillin-binding protein and serine/threonine kinase associated) domains. In prokaryotes, STKs modulate cellular functions such as growth, differentiation, and secondary metabolism. When the external environment changes, prokaryotes rely on signal transduction systems, including STKs that quickly sense these changes and alter gene expression to induce the appropriate metabolic changes.
Drug Classcephalosporin
Resistance Mechanismreduced permeability to antibiotic
Classification7 ontology terms | Show
Parent Term(s)2 ontology terms | Show
+ protein modulating permeability to antibiotic
+ confers_resistance_to_drug_class cephalosporin [Drug Class]
1 ontology terms | Show
+ IreK

Iannetta AA, et al. 2021. J Proteome Res 20(11):5131-5144 IreK-Mediated, Cell Wall-Protective Phosphorylation in Enterococcus faecalis. (PMID 34672600)

Kristich CJ, et al. 2011. mBio 2(6):e00199-11 Reciprocal regulation of cephalosporin resistance in Enterococcus faecalis. (PMID 22045988)

Kant S, et al. 2017. Sci Rep 7(1):5067 A novel STK1-targeted small-molecule as an antibiotic resistance breaker against multidrug-resistant Staphylococcus aureus. (PMID 28698584)