| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009213 |
| Synonym(s) | Candidozyma auris |
| Definition | The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| AMR Gene Family | azole resistant fungal 14 alpha demethylase |
| Drug Class | azole antibiotic, imidazole antibiotic, triazole antifungal |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic resistance gene variant or mutant + antifungal-resistant cytochrome P450 enzyme + azole antibiotic [Drug Class] + antibiotic target + antifungal resistant fungal 14 alpha demethylase + fungal ergosterol synthesis pathway enzyme + imidazole antibiotic [Drug Class] + triazole antifungal [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic fluconazole [Antibiotic] + derives_from antifungal susceptible ERG11 lanosterol-14-alpha-demethylase + azole resistant fungal 14 alpha demethylase [AMR Gene Family] |
| Publications | Williamson B, et al. 2022. Antimicrob Agents Chemother 66(1):e0162421 Impact of Erg11 Amino Acid Substitutions Identified in Candida auris Clade III Isolates on Triazole Drug Susceptibility. (PMID 34633842) Lockhart SR, et al. 2017. Clin Infect Dis 64(2):134-140 Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses. (PMID 27988485) Rhodes J, et al. 2018. Emerg Microbes Infect 7(1):43 Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris. (PMID 29593275) Healey KR, et al. 2018. Antimicrob Agents Chemother 62(10): Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility. (PMID 30082281) Chew KL, et al. 2021. Lett Appl Microbiol 73(3):286-293 Targeted amplification and MinION nanopore sequencing of key azole and echinocandin resistance determinants of clinically relevant Candida spp. from blood culture bottles. (PMID 34060660) Ceballos-Garzon A, et al. 2023. Front Cell Infect Microbiol 13:1136217 Emergence and circulation of azole-resistant C. albicans, C. auris and C. parapsilosis bloodstream isolates carrying Y132F, K143R or T220L Erg11p substitutions in Colombia. (PMID 37026059) Carolus H, et al. 2024. Nat Microbiol 9(11):2954-2969 Collateral sensitivity counteracts the evolution of antifungal drug resistance in Candida auris. (PMID 39472696) Bédard C, et al. 2025. Nat Microbiol : FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance. (PMID 40790106) |
Private model - RGI is not currently using this model.
| Curator | Description | Most Recent Edit |
|---|