| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009236 |
| Definition | The Hmg pathway is a primarily metabolic pathway that contributes to various functions inclusive of steroid synthesis. In fungi, the synthesis of a steroid precursor is vital to the eventual formation of ergosterol which is an integral part of the fungal cell membrane. Mutations in the Hmg gene have shown conferred resistance in certain fungi against azole drugs. |
| AMR Gene Family | antifungal resistant HMG-CoA reductase |
| Drug Class | azole antibiotic, triazole antifungal |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + antibiotic target alteration [Resistance Mechanism] + azole antibiotic [Drug Class] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + triazole antifungal [Drug Class] + antibiotic target + antibiotic resistance gene variant or mutant + fungal ergosterol synthesis pathway enzyme + antifungal resistant HMG-CoA reductase [AMR Gene Family] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic itraconazole [Antibiotic] + derives_from antifungal susceptible HMG-CoA reductase + azole resistant HMG-CoA reductase |
| Curator | Description | Most Recent Edit |
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