| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009397 |
| Synonym(s) | Nakaseomyces glabratus |
| Definition | The fungal Erg11 enzyme is lanosterol demethylase belongs to the broader P450 family. The enzyme contributes directly to ergosterol synthesis pathway. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Erg11 genes have been shown to inhibit azole activity. |
| AMR Gene Family | azole resistant fungal 14 alpha demethylase |
| Drug Class | azole antibiotic, imidazole antibiotic, triazole antifungal |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic resistance gene variant or mutant + antifungal-resistant cytochrome P450 enzyme + azole antibiotic [Drug Class] + antibiotic target + antifungal resistant fungal 14 alpha demethylase + fungal ergosterol synthesis pathway enzyme + imidazole antibiotic [Drug Class] + triazole antifungal [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic fluconazole [Antibiotic] + derives_from antifungal susceptible ERG11 lanosterol-14-alpha-demethylase + azole resistant fungal 14 alpha demethylase [AMR Gene Family] |
| Publications | Ksiezopolska E, et al. 2021. Curr Biol 31(23):5314-5326.e10 Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata. (PMID 34699784) Faria-Ramos I, et al. 2014. FEMS Yeast Res 14(7):1119-23 Environmental azole fungicide, prochloraz, can induce cross-resistance to medical triazoles in Candida glabrata. (PMID 25132632) Zeitoun H, et al. 2024. BMC Microbiol 24(1):383 Elucidation of the mechanisms of fluconazole resistance and repurposing treatment options against urinary Candida spp. isolated from hospitalized patients in Alexandria, Egypt. (PMID 39354378) Bédard C, et al. 2025. Nat Microbiol : FungAMR: a comprehensive database for investigating fungal mutations associated with antimicrobial resistance. (PMID 40790106) |
Private model - RGI is not currently using this model.
| Curator | Description | Most Recent Edit |
|---|