| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009402 |
| Synonym(s) | Mycosphaerella graminicola |
| Definition | The fungal Cyp51 enzyme system belongs to the broader P450 family. It is integral to ergosterol synthesis. Azoles target lanosterol demethylase thereby halting ergosterol production and ultimately compromises fungal cell membrane integrity. Mutations to Cyp51 genes have been shown to inhibit azole activity. |
| AMR Gene Family | azole-resistant fungal cytochrome P450 enzyme |
| Drug Class | azole antibiotic, benzimidazole antifungal, imidazole antibiotic, triazole antifungal |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 14 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + azole antibiotic [Drug Class] + antibiotic target + antibiotic resistance gene variant or mutant + benzimidazole antifungal [Drug Class] + fungal ergosterol synthesis pathway enzyme + antifungal-resistant cytochrome P450 enzyme + imidazole antibiotic [Drug Class] + triazole antifungal [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic propiconazole [Antibiotic] + azole-resistant fungal cytochrome P450 enzyme [AMR Gene Family] + derives_from antifungal susceptible Cyp51 enzyme |
| Publications | Leroux P, et al. 2007. Pest Manag Sci 63(7):688-98 Mutations in the CYP51 gene correlated with changes in sensitivity to sterol 14 alpha-demethylation inhibitors in field isolates of Mycosphaerella graminicola. (PMID 17511023) Cools HJ, et al. 2011. Appl Environ Microbiol 77(11):3830-7 Impact of recently emerged sterol 14{alpha}-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity. (PMID 21478305) |
| Curator | Description | Most Recent Edit |
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