| Ontology | CARD's Antibiotic Resistance Ontology |
| Accession | ARO:3009557 |
| Definition | Echinocandins inhibit beta-1,3-D-glucan synthase, disrupting fungal cell wall biosynthesis rather than sterol production. Although resistance to echinocandins is classically driven by mutations in the FKS genes, alterations in sterol biosynthesis pathways, including mutations in Cyp51, have been shown in some fungi to indirectly influence echinocandin susceptibility. Cyp51 mutations can modify membrane sterol composition and cell envelope architecture, affecting cell wall stress responses and compensatory signaling pathways. These secondary effects may reduce echinocandin efficacy and contribute to tolerance or reduced susceptibility, even though Cyp51 is not the direct molecular target of echinocandins. |
| AMR Gene Family | echinocandin-resistant fungal cytochrome P450 enzyme |
| Drug Class | echinocandin antibiotic |
| Resistance Mechanism | antibiotic target alteration |
| Classification | 11 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic target alteration [Resistance Mechanism] + mutation conferring antibiotic resistance + determinant of antibiotic resistance + antibiotic target + antibiotic molecule + antibiotic resistance gene variant or mutant + fungal ergosterol synthesis pathway enzyme + antifungal-resistant cytochrome P450 enzyme + echinocandin antibiotic [Drug Class] |
| Parent Term(s) | 3 ontology terms | Show + confers_resistance_to_antibiotic caspofungin [Antibiotic] + echinocandin-resistant fungal cytochrome P450 enzyme [AMR Gene Family] + derives_from antifungal susceptible Cyp51 enzyme |
| Curator | Description | Most Recent Edit |
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