bacitracin [Antibiotic]

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Accession ARO:0000041
Synonym(s)Ayfivin Penitracin Zutracin Topitracin Citracin BACiiM Fortracin Baciguent Baciquent Altracin
DefinitionBacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Bacitracin interferes with the dephosphorylation of the C55-isoprenyl pyrophosphate, a molecule which carries the building blocks of the peptidoglycan bacterial cell wall outside of the inner membrane.
Drug Classpeptide antibiotic
Classification2 ontology terms | Show
Parent Term(s)2 ontology terms | Show
6 ontology terms | Show
+ bacitracin A [Antibiotic]
+ bacitracin B [Antibiotic]
+ bacitracin F [Antibiotic]
+ BahA confers_resistance_to_antibiotic
+ bacitracin sensitive isoprenyl pyrophosphate targeted_by_antibiotic
+ undecaprenyl pyrophosphate targeted_by_antibiotic

Cain BD, et al. 1993. J Bacteriol 175(12): 3784-3789. Amplification of the bacA gene confers bacitracin resistance to Escherichia coli. (PMID 8389741)