bacitracin sensitive isoprenyl pyrophosphate

Accession ARO:3000719
DefinitionIsoprepnyl pyrophosphate removes a phosphate group that is added from the peptidoglycan subunit to permit its transfer across the cell membrane. The phosphate group must be removed before its incorporation into peptidoglycan macromolecules.
Classification2 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ targeted_by_antibiotic bacitracin [Antibiotic]
+ targeted_by_antibiotic bacitracin A [Antibiotic]
+ targeted_by_antibiotic bacitracin B [Antibiotic]
+ targeted_by_antibiotic bacitracin F [Antibiotic]
+ cell wall synthesis enzyme targeted by antibiotic
Publications

Stone KJ and Strominger JL. 1971. Proc Natl Acad Sci U S A 68(12): 3223-3227. Mechanism of action of bacitracin: complexation with metal ion and C 55 -isoprenyl pyrophosphate. (PMID 4332017)

Toscano WA Jr and Storm DR. 1982. Pharmacol Ther 16(2): 199-210. Bacitracin. (PMID 6752975)

Storm DR and Strominger JL. 1973. J Biol Chem 248(11): 3940-3945. Complex formation between bacitracin peptides and isoprenyl pyrophosphates. The specificity of lipid-peptide interactions. (PMID 4350651)

Kim SJ, et al. 2008. J Mol Biol 377(1): 281-293. Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus. (PMID 18258256)