Accession | ARO:3000719 |
Definition | Isoprepnyl pyrophosphate removes a phosphate group that is added from the peptidoglycan subunit to permit its transfer across the cell membrane. The phosphate group must be removed before its incorporation into peptidoglycan macromolecules. |
Classification | 2 ontology terms | Show |
Parent Term(s) | 5 ontology terms | Show + targeted_by_antibiotic bacitracin [Antibiotic] + targeted_by_antibiotic bacitracin A [Antibiotic] + targeted_by_antibiotic bacitracin B [Antibiotic] + targeted_by_antibiotic bacitracin F [Antibiotic] + cell wall synthesis enzyme targeted by antibiotic |
Publications | Stone KJ and Strominger JL. 1971. Proc Natl Acad Sci U S A 68(12): 3223-3227. Mechanism of action of bacitracin: complexation with metal ion and C 55 -isoprenyl pyrophosphate. (PMID 4332017) Toscano WA Jr and Storm DR. 1982. Pharmacol Ther 16(2): 199-210. Bacitracin. (PMID 6752975) Storm DR and Strominger JL. 1973. J Biol Chem 248(11): 3940-3945. Complex formation between bacitracin peptides and isoprenyl pyrophosphates. The specificity of lipid-peptide interactions. (PMID 4350651) Kim SJ, et al. 2008. J Mol Biol 377(1): 281-293. Oritavancin exhibits dual mode of action to inhibit cell-wall biosynthesis in Staphylococcus aureus. (PMID 18258256) |