| Accession | ARO:3000074 |
| Definition | emrB is a translocase in the emrB -TolC efflux protein in E. coli. It recognizes substrates including carbonyl cyanide m-chlorophenylhydrazone (CCCP), nalidixic acid, and thioloactomycin. |
| AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
| Drug Class | fluoroquinolone antibiotic |
| Resistance Mechanism | antibiotic efflux |
| Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
| Resistomes | Escherichia colig+wgs, Shigella dysenteriaeg+wgs, Shigella flexneriwgs, Shigella sonneig+wgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + antibiotic molecule + determinant of antibiotic resistance + antibiotic efflux [Resistance Mechanism] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + fluoroquinolone antibiotic [Drug Class] + nalidixic acid [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] |
| Parent Term(s) | 2 ontology terms | Show |
| Publications | Lomovskaya O, et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89(19):8938-42 Emr, an Escherichia coli locus for multidrug resistance. (PMID 1409590) |
Prevalence of emrB among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 82 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS |
|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 0.11% |
| Citrobacter amalonaticus | 100% | 0% | 100% |
| Citrobacter freundii | 96.55% | 0% | 98.45% |
| Citrobacter koseri | 100% | 0% | 100% |
| Citrobacter youngae | 100% | 0% | 75% |
| Enterobacter asburiae | 100% | 0% | 96.88% |
| Enterobacter cloacae | 100% | 0% | 94.13% |
| Enterobacter hormaechei | 97.3% | 0% | 99.37% |
| Enterobacter kobei | 100% | 0% | 96.88% |
| Enterococcus faecium | 0% | 0% | 0% |
| Escherichia coli | 12.95% | 0% | 86.21% |
| Klebsiella oxytoca | 0% | 0% | 2.8% |
| Klebsiella pneumoniae | 0% | 0% | 0% |
| Listeria monocytogenes | 0% | 0% | 0.04% |
| Morganella morganii | 0% | 0% | 2.38% |
| Pseudomonas aeruginosa | 0% | 0% | 0% |
| Raoultella planticola | 0% | 0% | 5.26% |
| Salmonella enterica | 97.29% | 0.35% | 99.5% |
| Serratia marcescens | 0% | 0% | 0.23% |
| Shigella dysenteriae | 100% | 0% | 100% |
| Shigella flexneri | 100% | 0% | 99.48% |
| Shigella sonnei | 100% | 0% | 99.92% |
| Stenotrophomonas maltophilia | 0% | 0% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.25% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 900