| Accession | ARO:3000090 |
| CARD Short Name | Bla1 |
| Definition | Bla1 is a chromosomal-encoded beta-lactamase, found in Bacillus anthracis, which hydrolyzes penicillins. |
| AMR Gene Family | class A Bacillus anthracis Bla beta-lactamase |
| Drug Class | penam |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Bacillus anthraciswgs |
| Resistomes with Sequence Variants | Bacillus anthracisg+wgs, Bacillus cereusg+wgs, Bacillus thuringiensisg+wgs |
| Classification | 12 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + hydrolysis of antibiotic conferring resistance + antibiotic molecule + hydrolysis of beta-lactam antibiotic by serine beta-lactamase + beta-lactam antibiotic + beta-lactamase + class A beta-lactamase + penam [Drug Class] |
| Parent Term(s) | 1 ontology terms | Show + class A Bacillus anthracis Bla beta-lactamase [AMR Gene Family] |
| Publications | Materon IC, et al. 2003. Antimicrob Agents Chemother 47(6): 2040-2042. Biochemical characterization of beta-lactamases Bla1 and Bla2 from Bacillus anthracis. (PMID 12760895) Kim SK, et al. 2016. J Enzyme Inhib Med Chem :1-6 Inhibition of Bacillus anthracis metallo-β-lactamase by compounds with hydroxamic acid functionality. (PMID 27557855) |
Prevalence of Bla1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Bacillus anthracis | 96.72% | 0% | 71.05% | 0% |
| Bacillus cereus | 1.08% | 0% | 0.3% | 0% |
| Bacillus thuringiensis | 3.75% | 0% | 0.17% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 600