gramicidin D [Antibiotic]

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Accession ARO:3000199
DefinitionGramicidin D is a mixture of the linear peptides gramicidin A, B, and C, each with 15 alternating L- and D-amino acids. They are active against most gram-positive bacteria and select gram-negative bacteria. These compounds create channels in the bacterial membrane and increase the permeability to cations.
Drug Classpeptide antibiotic
Classification4 ontology terms | Show
Parent Term(s)5 ontology terms | Show
+ antibiotic mixture
+ has_part gramicidin A [Antibiotic]
+ has_part gramicidin B [Antibiotic]
+ has_part gramicidin C [Antibiotic]
+ gramicidin [Antibiotic]

Kelkar DA and Chattopadhyay A. 2007. Biochim Biophys Acta 1768(9): 2011-2025. The gramicidin ion channel: a model membrane protein. (PMID 17572379)

Bourinbaiar AS and Coleman CF. 1998. Arch Virol 142(11): 2225-2235. The effect of gramicidin, a topical contraceptive and antimicrobial agent with anti-HIV activity, against herpes simplex viruses type 1 and 2 in vitro. (PMID 9672588)