Accession | ARO:3000516 |
Synonym(s) | mprA |
CARD Short Name | emrR |
Definition | EmrR is a negative regulator for the EmrAB-TolC multidrug efflux pump in E. coli. Mutations lead to EmrAB-TolC overexpression. |
AMR Gene Family | major facilitator superfamily (MFS) antibiotic efflux pump |
Drug Class | fluoroquinolone antibiotic |
Resistance Mechanism | antibiotic efflux |
Efflux Component | efflux pump complex or subunit conferring antibiotic resistance |
Efflux Regulator | protein(s) and two-component regulatory system modulating antibiotic efflux |
Resistomes with Perfect Matches | Escherichia colig+p+wgs, Escherichia fergusoniig+wgs, Shigella boydiig+wgs, Shigella dysenteriaewgs, Shigella flexnerig+wgs, Shigella sonneig+wgs |
Resistomes with Sequence Variants | Burkholderia pseudomalleiwgs, Citrobacter amalonaticusg+wgs, Citrobacter freundiig+wgs, Citrobacter koserig+wgs, Citrobacter portucalensisg+wgs, Citrobacter werkmaniig+wgs, Citrobacter youngaeg+wgs, Cronobacter sakazakiig+wgs, Enterobacter asburiaeg+wgs, Enterobacter chengduensisg+wgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheig+p+wgs, Enterobacter kobeig+wgs, Enterobacter roggenkampiig+wgs, Escherichia albertiig+wgs, Escherichia colig+p+wgs, Escherichia fergusoniig+wgs, Escherichia marmotaeg+wgs, Klebsiella aerogenesg+wgs, Klebsiella huaxiensisg+wgs, Klebsiella michiganensisg+wgs, Klebsiella oxytocag+wgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaeg+wgs, Kosakonia arachidisg+wgs, Leclercia adecarboxylatag+wgs, Mycobacterium aviumwgs, Pseudomonas aeruginosawgs, Raoultella planticolag+wgs, Salmonella entericag+p+wgs, Serratia marcescenswgs, Serratia rubidaeag, Shigella boydiig+wgs, Shigella dysenteriaeg+wgs, Shigella flexnerig+wgs, Shigella sonneig+wgs, Vibrio choleraewgs, Vibrio vulnificuswgs |
Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic efflux [Resistance Mechanism] + fluoroquinolone antibiotic [Drug Class] + efflux pump complex or subunit conferring antibiotic resistance [Efflux Component] + nalidixic acid [Antibiotic] + major facilitator superfamily (MFS) antibiotic efflux pump [AMR Gene Family] |
Parent Term(s) | 2 ontology terms | Show + regulates EmrAB-TolC + protein(s) and two-component regulatory system modulating antibiotic efflux [Efflux Regulator] |
Publications | Lomovskaya O, et al. 1995. J Bacteriol 177(9): 2328-2334. EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB. (PMID 7730261) |
Prevalence of emrR among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 263 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
---|---|---|---|---|
Burkholderia pseudomallei | 0% | 0% | 0.06% | 0% |
Citrobacter amalonaticus | 100% | 0% | 87.5% | 0% |
Citrobacter freundii | 99.23% | 0% | 60.76% | 0% |
Citrobacter koseri | 100% | 0% | 46.67% | 0% |
Citrobacter portucalensis | 100% | 0% | 86% | 0% |
Citrobacter werkmanii | 100% | 0% | 100% | 0% |
Citrobacter youngae | 100% | 0% | 100% | 0% |
Cronobacter sakazakii | 100% | 0% | 93.38% | 0% |
Enterobacter asburiae | 100% | 0% | 88.19% | 0% |
Enterobacter chengduensis | 100% | 0% | 90.91% | 0% |
Enterobacter cloacae | 97.73% | 0.74% | 80.91% | 0% |
Enterobacter hormaechei | 99.4% | 0.17% | 80.53% | 0% |
Enterobacter kobei | 91.67% | 0% | 86.89% | 0% |
Enterobacter roggenkampii | 100% | 0% | 73.94% | 0% |
Escherichia albertii | 100% | 0% | 97.7% | 0% |
Escherichia coli | 61.46% | 0.02% | 74.64% | 0% |
Escherichia fergusonii | 100% | 0% | 44.62% | 0% |
Escherichia marmotae | 100% | 0% | 66.67% | 0% |
Klebsiella aerogenes | 100% | 0% | 81.45% | 0% |
Klebsiella huaxiensis | 100% | 0% | 50% | 0% |
Klebsiella michiganensis | 97.67% | 0% | 75.97% | 0% |
Klebsiella oxytoca | 100% | 0% | 82.03% | 0% |
Klebsiella pneumoniae | 99.34% | 0.03% | 71.99% | 0% |
Klebsiella quasipneumoniae | 100% | 0% | 81.54% | 0% |
Kosakonia arachidis | 100% | 0% | 100% | 0% |
Leclercia adecarboxylata | 100% | 0% | 90.48% | 0% |
Mycobacterium avium | 0% | 0% | 0.48% | 0% |
Pseudomonas aeruginosa | 0% | 0% | 0.04% | 0% |
Raoultella planticola | 100% | 0% | 94.12% | 0% |
Salmonella enterica | 94.6% | 0.07% | 89.4% | 0% |
Serratia marcescens | 0% | 0% | 0.15% | 0% |
Serratia rubidaea | 20% | 0% | 0% | 0% |
Shigella boydii | 100% | 0% | 95.7% | 0% |
Shigella dysenteriae | 90.91% | 0% | 100% | 0% |
Shigella flexneri | 100% | 0% | 83.5% | 0% |
Shigella sonnei | 100% | 0% | 95.93% | 0% |
Vibrio cholerae | 0% | 0% | 0.07% | 0% |
Vibrio vulnificus | 0% | 0% | 0.87% | 0% |
Model Type: protein homolog model
Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.
Bit-score Cut-off (blastP): 280