ceftaroline [Antibiotic]

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Accession ARO:3000651
Synonym(s)ceftaroline fosamil CPT T91825
DefinitionCeftaroline is a novel cephalosporin active against methicillin resistant Staphylococcus aureus. Like other cephalosporins it binds penicillin-binding proteins to inhibit cell wall synthesis. It strongly binds with PBP2a, associated with methicillin resistance. It is taken orally as the prodrug ceftaroline fosamil.
Drug Classcephalosporin
Classification4 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ cephalosporin [Drug Class]
3 ontology terms | Show

Ikeda Y, et al. 2008. Chem Pharm Bull (Tokyo) 56(10): 1406-1411. Stability and stabilization studies of TAK-599 (Ceftaroline Fosamil), a novel N-phosphono type prodrug of anti-methicillin resistant Staphylococcus aureus cephalosporin T-91825. (PMID 18827379)

Saravolatz LD, et al. 2011. Clin Infect Dis 52(9): 1156-1163. Ceftaroline: a novel cephalosporin with activity against methicillin-resistant Staphylococcus aureus. (PMID 21467022)

Gaikwad V, et al. . Indian J Pathol Microbiol 59(4):496-498 In vitro activity of ceftaroline: A novel antibiotic against methicillin-resistant Staphylococcus aureus. (PMID 27721280)