| Accession | ARO:3001205 |
| Synonym(s) | blmS ble BRP blmA |
| CARD Short Name | BRP(MBL) |
| Definition | A novel bleomycin resistance protein encoded by a metallo-beta-lactamase-associated ble gene. Expression of BRP(MBL) confers resistance to bleomycin and bleomycin-like antibiotics in Enterobacteriaceae and Acinetobacter, where it is co-expressed with an MBL and controlled by the same promoter region. |
| AMR Gene Family | Bleomycin resistant protein |
| Drug Class | glycopeptide antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Perfect Matches | Acinetobacter baumanniiwgs, Acinetobacter haemolyticuswgs, Acinetobacter indicuswgs, Acinetobacter johnsoniiwgs, Acinetobacter juniiwgs, Acinetobacter lwoffiiwgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Acinetobacter radioresistenswgs, Acinetobacter towneriwgs, Aeromonas caviaewgs, Aeromonas veroniiwgs, Citrobacter amalonaticuswgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Citrobacter youngaep, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Escherichia fergusoniip, Klebsiella aerogenesp+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatawgs, Morganella morganiig+p+wgs, Proteus mirabilisp+wgs, Proteus penneriwgs, Proteus vulgarisp, Providencia rettgeriwgs, Providencia stuartiiwgs, Pseudomonas aeruginosawgs, Pseudomonas putidawgs, Salmonella entericag+p+wgs, Serratia marcescensp+wgs, Shigella sonneiwgs, Vibrio alginolyticuswgs, Vibrio fluvialisg, Vibrio parahaemolyticuswgs, Vibrio vulnificuswgs |
| Resistomes with Sequence Variants | Acinetobacter baumanniiwgs, Acinetobacter haemolyticuswgs, Acinetobacter indicuswgs, Acinetobacter johnsoniiwgs, Acinetobacter juniiwgs, Acinetobacter lwoffiiwgs, Acinetobacter nosocomialiswgs, Acinetobacter pittiiwgs, Acinetobacter radioresistenswgs, Acinetobacter towneriwgs, Aeromonas caviaewgs, Aeromonas veroniiwgs, Bordetella trematumg, Citrobacter amalonaticuswgs, Citrobacter freundiip+wgs, Citrobacter koserip+wgs, Citrobacter portucalensiswgs, Citrobacter werkmaniiwgs, Citrobacter youngaep, Comamonas testosteroniwgs, Enterobacter asburiaep+wgs, Enterobacter chengduensiswgs, Enterobacter cloacaeg+p+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip+wgs, Enterobacter roggenkampiiwgs, Escherichia colig+p+wgs, Escherichia fergusoniip, Klebsiella aerogenesp+wgs, Klebsiella michiganensisp+wgs, Klebsiella oxytocawgs, Klebsiella pneumoniaeg+p+wgs, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatawgs, Morganella morganiig+p+wgs, Proteus mirabilisp+wgs, Proteus penneriwgs, Proteus vulgarisp, Providencia rettgeriwgs, Providencia stuartiiwgs, Pseudomonas aeruginosap+wgs, Pseudomonas putidawgs, Salmonella entericag+p+wgs, Serratia marcescensp+wgs, Shigella sonneiwgs, Stenotrophomonas maltophiliag, Vibrio alginolyticuswgs, Vibrio fluvialisg, Vibrio parahaemolyticuswgs, Vibrio vulnificuswgs |
| Classification | 9 ontology terms | Show + process or component of antibiotic biology or chemistry + antibiotic molecule + mechanism of antibiotic resistance + antibiotic mixture + glycopeptide antibiotic [Drug Class] + antibiotic inactivation [Resistance Mechanism] + determinant of antibiotic resistance + bleomycin [Antibiotic] + gene involved in antibiotic sequestration |
| Parent Term(s) | 5 ontology terms | Show + confers_resistance_to_antibiotic bleomycinic acid [Antibiotic] + participates_in antibiotic inactivation by sequestration + confers_resistance_to_antibiotic bleomycin A2 [Antibiotic] + Bleomycin resistant protein [AMR Gene Family] + confers_resistance_to_antibiotic bleomycin B2 [Antibiotic] |
| Publications | Dortet L, et al. 2012. Antimicrob Agents Chemother 56(4): 1693-1697. Association of the emerging carbapenemase NDM-1 with a bleomycin resistance protein in Enterobacteriaceae and Acinetobacter baumannii. (PMID 22290943) Mori T, et al. 2008. Appl Environ Microbiol 74(21): 6803-6805. Metagenomic screening for bleomycin resistance genes. (PMID 18791008) |
Prevalence of BRP(MBL) among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0% | 0% | 2.23% | 0% |
| Acinetobacter haemolyticus | 0% | 0% | 2.33% | 0% |
| Acinetobacter indicus | 0% | 0% | 1.3% | 0% |
| Acinetobacter johnsonii | 0% | 0% | 5.45% | 0% |
| Acinetobacter junii | 0% | 0% | 4.48% | 0% |
| Acinetobacter lwoffii | 0% | 0% | 5.26% | 0% |
| Acinetobacter nosocomialis | 0% | 0% | 2.3% | 0% |
| Acinetobacter pittii | 0% | 0% | 4.83% | 0% |
| Acinetobacter radioresistens | 0% | 0% | 1.75% | 0% |
| Acinetobacter towneri | 0% | 0% | 3.85% | 0% |
| Aeromonas caviae | 0% | 0% | 3.76% | 0% |
| Aeromonas veronii | 0% | 0% | 0.56% | 0% |
| Bordetella trematum | 20% | 0% | 0% | 0% |
| Citrobacter amalonaticus | 0% | 0% | 5.45% | 0% |
| Citrobacter freundii | 0% | 1.54% | 4.84% | 0% |
| Citrobacter koseri | 0% | 5% | 0.9% | 0% |
| Citrobacter portucalensis | 0% | 0% | 7.21% | 0% |
| Citrobacter werkmanii | 0% | 0% | 17.95% | 0% |
| Citrobacter youngae | 0% | 9.09% | 0% | 0% |
| Comamonas testosteroni | 0% | 0% | 7.14% | 0% |
| Enterobacter asburiae | 0% | 0.28% | 4.35% | 0% |
| Enterobacter chengduensis | 0% | 0% | 8% | 0% |
| Enterobacter cloacae | 1.79% | 1.68% | 3.51% | 0% |
| Enterobacter hormaechei | 0% | 1.93% | 5.44% | 0% |
| Enterobacter kobei | 0% | 1.38% | 3.06% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 2.88% | 0% |
| Escherichia coli | 0.02% | 0.47% | 1.78% | 0% |
| Escherichia fergusonii | 0% | 0.36% | 0% | 0% |
| Klebsiella aerogenes | 0% | 3.26% | 1.41% | 0% |
| Klebsiella michiganensis | 0% | 4.57% | 2.93% | 0% |
| Klebsiella oxytoca | 0% | 0% | 2.1% | 0% |
| Klebsiella pneumoniae | 0.53% | 1.59% | 3.97% | 0% |
| Klebsiella quasipneumoniae | 0% | 1.27% | 5.92% | 0% |
| Leclercia adecarboxylata | 0% | 0% | 4.65% | 0% |
| Morganella morganii | 1.92% | 2.5% | 2.45% | 0% |
| Proteus mirabilis | 0% | 2.5% | 1.98% | 0% |
| Proteus penneri | 0% | 0% | 12.5% | 0% |
| Proteus vulgaris | 0% | 11.11% | 0% | 0% |
| Providencia rettgeri | 0% | 0% | 8.92% | 0% |
| Providencia stuartii | 0% | 0% | 6.82% | 0% |
| Pseudomonas aeruginosa | 0% | 2.34% | 0.21% | 0% |
| Pseudomonas putida | 0% | 0% | 0.53% | 0% |
| Salmonella enterica | 0.13% | 0.16% | 0.03% | 0% |
| Serratia marcescens | 0% | 2.58% | 0.92% | 0% |
| Shigella sonnei | 0% | 0% | 0.07% | 0% |
| Stenotrophomonas maltophilia | 1.12% | 0% | 0% | 0% |
| Vibrio alginolyticus | 0% | 0% | 0.79% | 0% |
| Vibrio fluvialis | 2.63% | 0% | 0% | 0% |
| Vibrio parahaemolyticus | 0% | 0% | 0.1% | 0% |
| Vibrio vulnificus | 0% | 0% | 0.41% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 200