AER-1

Accession ARO:3002481
DefinitionAER-1 is a beta-lactamase found in Aeromonas hydrophila
AMR Gene FamilyAER beta-lactamase
Drug Classpenam
Resistance Mechanismantibiotic inactivation
Classification13 ontology terms | Show
Parent Term(s)1 ontology terms | Show
+ AER beta-lactamase [AMR Gene Family]
Publications

Hedges RW, et al. 1985. Antimicrob. Agents Chemother. 27(4):479-84 Genetic and biochemical properties of AER-1, a novel carbenicillin-hydrolyzing beta-lactamase from Aeromonas hydrophila. (PMID 3890725)

Resistomes

Prevalence of AER-1 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI for 85 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGS
No prevalence data


Detection Models

Model Type: protein homolog model

Model Definition: The protein homolog model is an AMR detection model. Protein homolog models detect a protein sequence based on its similarity to a curated reference sequence. A protein homolog model has only one parameter: a curated BLASTP bitscore cutoff for determining the strength of a match. Protein homolog model matches to reference sequences are categorized on three criteria: perfect, strict and loose. A perfect match is 100% identical to the reference sequence along its entire length; a strict match is not identical but the bitscore of the matched sequence is greater than the curated BLASTP bitscore cutoff. Loose matches are other sequences with a match bitscore less than the curated BLASTP bitscore.

Bit-score Cut-off (blastP): 600


>gb|AAC09015.1|+|AER-1 [Aeromonas hydrophila]
MYVLSVEKPTLRNKFAAGIGVVLVCVVASFIPTPVFALDTTKLIQAVQSEESALHARVGMTVFDSNTGTTWNYRGDERFPLNSTHKTFSC
AALLAKVDGKSLSLGQSVSISKEMLVTYSPITEKSLSPETVTFGKICQAAVSYSDNTAANVVFDAIGGATGFNAYMRSIGDEETQLDRKE
PELNEGTPGDVRDTTTPNAMVNSLRKILLGDALSASSRSQLTQWMLDDQVAGALLRASLPSDWKIADKTGAGGYGSRSIVAVIWPPSKQP
LVVGIYITQTKASMQASNQAIARIGVVLKDTVAP


>gb|U14748|+|325-1239|AER-1 [Aeromonas hydrophila]
ATGTACGTACTTTCCGTGGAGAAACCTACATTGAGAAACAAATTTGCGGCCGGAATAGGCGTCGTGCTTGTATGTGTCGTTGCCTCGTTT
ATTCCAACCCCAGTATTCGCCCTAGACACCACGAAGCTGATCCAAGCCGTCCAGTCGGAAGAGAGCGCCTTGCATGCCCGAGTCGGCATG
ACCGTGTTTGACTCAAACACTGGAACGACTTGGAACTATCGGGGCGATGAGCGGTTTCCATTGAACAGTACGCACAAGACGTTTTCCTGT
GCAGCTTTGCTCGCGAAGGTCGATGGGAAGTCCCTCTCTCTGGGCCAATCCGTATCGATCAGCAAGGAAATGCTGGTCACCTATTCGCCG
ATTACGGAAAAGTCGCTGTCACCCGAAACCGTTACCTTCGGCAAGATTTGTCAGGCAGCGGTGAGCTATAGCGATAACACAGCCGCAAAC
GTCGTCTTTGATGCCATTGGAGGAGCAACCGGATTCAACGCATACATGCGGTCTATCGGCGATGAAGAAACCCAGCTTGATCGCAAAGAA
CCCGAGTTGAACGAAGGTACGCCGGGCGATGTGCGTGACACCACCACTCCCAACGCCATGGTCAATAGTCTTAGGAAGATACTTCTTGGC
GACGCGTTGTCAGCATCATCCCGATCCCAGCTGACGCAATGGATGCTGGACGATCAGGTTGCTGGTGCGCTCCTGCGTGCCTCACTGCCA
TCCGATTGGAAGATCGCCGACAAGACCGGCGCGGGGGGTTACGGCTCACGCTCGATCGTCGCAGTAATCTGGCCGCCATCGAAGCAGCCA
CTGGTGGTTGGCATCTATATCACGCAAACCAAAGCATCCATGCAGGCCAGCAATCAGGCGATTGCAAGGATAGGAGTGGTGCTGAAGGAT
ACGGTCGCTCCTTGA