Bacillus pumilus cat86

Accession ARO:3002672
CARD Short NameBpum_cat86
Definitioncat86 is a chromosome-encoded variant of the cat gene found in Bacillus pumilus.
AMR Gene Familychloramphenicol acetyltransferase (CAT)
Drug Classphenicol antibiotic
Resistance Mechanismantibiotic inactivation
Resistomes with Perfect MatchesBacillus pumiluswgs
Resistomes with Sequence VariantsBacillus pumilusg+wgs
Classification8 ontology terms | Show
Parent Term(s)4 ontology terms | Show
+ chloramphenicol acetyltransferase (CAT) [AMR Gene Family]
+ confers_resistance_to_antibiotic chloramphenicol [Antibiotic]
+ confers_resistance_to_antibiotic azidamfenicol [Antibiotic]
+ confers_resistance_to_antibiotic thiamphenicol [Antibiotic]
Publications

Harwood CR, et al. 1983. Gene 24(2-3): 163-169. Nucleotide sequence of a Bacillus pumilus gene specifying chloramphenicol acetyltransferase. (PMID 6315534)

Resistomes

Prevalence of Bacillus pumilus cat86 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).

Prevalence: protein homolog model (view sequences)

SpeciesNCBI ChromosomeNCBI PlasmidNCBI WGSNCBI GI
Bacillus pumilus95%0%50.28%0%
Show Perfect Only


Detection Models

Model Type: protein homolog model

Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.

Bit-score Cut-off (blastP): 400


>gb|AAA22289.1|+|Bacillus pumilus cat86 [Bacillus pumilus]
MFKQIDENYLRKEHFHHYMTLTRCSYSLVINLDITKLHAILKEKKLKVYPVQIYLLARAVQKIPEFRMDQVNDELGYWEILHPSYTILNK
ETKTFSSIWTPFDENFAQFYKSCVADIETFSKSSNLFPKPHMPENMFNISSLPWIDFTSFNLNVSTDEAYLLPIFTIGKFKVEEGKIILP
VAIQVHHAVCDGYHAGQYVEYLRWLIEHCDEWLNDSLHIT


>gb|K00544.1|+|1-663|Bacillus pumilus cat86 [Bacillus pumilus]
TTGTTTAAACAAATAGACGAAAATTATCTGCGAAAAGAGCACTTTCACCATTATATGACGTTAACCCGATGCTCATATAGCTTGGTGATC
AATCTAGACATCACGAAATTGCATGCAATATTAAAAGAAAAAAAGCTGAAAGTATATCCTGTGCAAATTTATTTGTTAGCAAGAGCTGTG
CAAAAAATTCCTGAGTTTCGGATGGATCAAGTGAACGATGAACTTGGTTACTGGGAGATTCTCCATCCTAGTTATACGATTCTAAATAAA
GAAACAAAGACGTTTTCAAGTATTTGGACGCCTTTTGATGAAAACTTTGCTCAGTTTTATAAAAGCTGTGTAGCCGATATTGAAACATTT
AGCAAAAGCAGCAACCTATTTCCGAAACCTCATATGCCAGAAAACATGTTCAATATTTCAAGTCTACCGTGGATTGATTTTACTTCTTTT
AACCTTAATGTATCTACAGATGAAGCTTATTTACTGCCTATATTTACGATAGGCAAATTTAAGGTGGAAGAAGGAAAAATCATTTTGCCC
GTTGCCATACAAGTACATCATGCTGTTTGTGATGGCTATCATGCCGGTCAATATGTTGAATATTTGAGGTGGCTTATTGAACATTGTGAC
GAGTGGTTAAATGATTCATTGCATATTACCTGA