| Accession | ARO:3002675 |
| CARD Short Name | catB2 |
| Definition | catB2 is a plasmid-encoded variant of the cat gene found in Escherichia coli, Salmonella enteritidis and Pasteurella multocida. |
| AMR Gene Family | chloramphenicol acetyltransferase (CAT) |
| Drug Class | phenicol antibiotic |
| Resistance Mechanism | antibiotic inactivation |
| Resistomes with Sequence Variants | Acinetobacter baumanniig+wgs, Citrobacter freundiip+wgs, Citrobacter portucalensiswgs, Enterobacter asburiaewgs, Enterobacter cloacaep+wgs, Enterobacter hormaecheip+wgs, Enterobacter kobeip, Enterobacter roggenkampiiwgs, Escherichia colip+wgs, Klebsiella aerogenesp+wgs, Klebsiella michiganensisg+p, Klebsiella oxytocap, Klebsiella pneumoniaeg+p+wgs+gi, Klebsiella quasipneumoniaep+wgs, Leclercia adecarboxylatag+p, Morganella morganiiwgs, Neisseria brasiliensisg+gi, Proteus mirabiliswgs, Proteus penneriwgs, Proteus vulgariswgs, Providencia heimbachaeg+wgs+gi, Providencia rettgerig+wgs, Pseudomonas aeruginosawgs, Salmonella entericawgs, Serratia marcescenswgs |
| Classification | 8 ontology terms | Show + process or component of antibiotic biology or chemistry + mechanism of antibiotic resistance + determinant of antibiotic resistance + antibiotic molecule + antibiotic inactivation [Resistance Mechanism] + antibiotic inactivation enzyme + phenicol antibiotic [Drug Class] + acylation of antibiotic conferring resistance |
| Parent Term(s) | 4 ontology terms | Show + chloramphenicol acetyltransferase (CAT) [AMR Gene Family] + confers_resistance_to_antibiotic chloramphenicol [Antibiotic] + confers_resistance_to_antibiotic azidamfenicol [Antibiotic] + confers_resistance_to_antibiotic thiamphenicol [Antibiotic] |
| Publications | Villa L, et al. 2002. J Clin Microbiol 40(7): 2662-2665. Multidrug and broad-spectrum cephalosporin resistance among Salmonella enterica serotype enteritidis clinical isolates in southern Italy. (PMID 12089302) Tennstedt T, et al. 2003. FEMS Microbiol Ecol 45(3): 239-252. Occurrence of integron-associated resistance gene cassettes located on antibiotic resistance plasmids isolated from a wastewater treatment plant. (PMID 19719593) Parent R and Roy PH. 1992. J Bacteriol 174(9): 2891-2897. The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat. (PMID 1314803) |
Prevalence of catB2 among the sequenced genomes, plasmids, and whole-genome shotgun assemblies available at NCBI or IslandViewer for 413 important pathogens (see methodological details and complete list of analyzed pathogens). Values reflect percentage of genomes, plasmids, genome islands, or whole-genome shotgun assemblies that have at least one hit to the AMR detection model. Default view includes percentages calculated based on Perfect plus Strict RGI hits. Select the checkbox to view percentages based on only Perfect matches to AMR reference sequences curated in CARD (note: this excludes resistance via mutation as references in protein variant models are often wild-type, sensitive sequences).
| Species | NCBI Chromosome | NCBI Plasmid | NCBI WGS | NCBI GI |
|---|---|---|---|---|
| Acinetobacter baumannii | 0.18% | 0% | 0.03% | 0% |
| Citrobacter freundii | 0% | 0.31% | 2.13% | 0% |
| Citrobacter portucalensis | 0% | 0% | 3.6% | 0% |
| Enterobacter asburiae | 0% | 0% | 1.19% | 0% |
| Enterobacter cloacae | 0% | 0.56% | 0.64% | 0% |
| Enterobacter hormaechei | 0% | 0.13% | 0.6% | 0% |
| Enterobacter kobei | 0% | 0.69% | 0% | 0% |
| Enterobacter roggenkampii | 0% | 0% | 1.8% | 0% |
| Escherichia coli | 0% | 0.03% | 0.03% | 0% |
| Klebsiella aerogenes | 0% | 1.09% | 0.28% | 0% |
| Klebsiella michiganensis | 1.61% | 0.57% | 0% | 0% |
| Klebsiella oxytoca | 0% | 0.68% | 0% | 0% |
| Klebsiella pneumoniae | 0.06% | 0.09% | 0.28% | 0.95% |
| Klebsiella quasipneumoniae | 0% | 0.21% | 0.26% | 0% |
| Leclercia adecarboxylata | 7.14% | 4.76% | 0% | 0% |
| Morganella morganii | 0% | 0% | 2.45% | 0% |
| Neisseria brasiliensis | 100% | 0% | 0% | 50% |
| Proteus mirabilis | 0% | 0% | 0.99% | 0% |
| Proteus penneri | 0% | 0% | 12.5% | 0% |
| Proteus vulgaris | 0% | 0% | 11.11% | 0% |
| Providencia heimbachae | 50% | 0% | 14.29% | 100% |
| Providencia rettgeri | 5.88% | 0% | 1.91% | 0% |
| Pseudomonas aeruginosa | 0% | 0% | 0.03% | 0% |
| Salmonella enterica | 0% | 0% | 0.01% | 0% |
| Serratia marcescens | 0% | 0% | 0.39% | 0% |
Model Type: protein homolog model
Model Definition: Protein Homolog Models (PHM) detect protein sequences based on their similarity to a curated reference sequence, using curated BLASTP bitscore cut-offs. Protein Homolog Models apply to all genes that confer resistance through their presence in an organism, such as the presence of a beta-lactamase gene on a plasmid. PHMs include a reference sequence and a bitscore cut-off for detection using BLASTP. A Perfect RGI match is 100% identical to the reference protein sequence along its entire length, a Strict RGI match is not identical but the bit-score of the matched sequence is greater than the curated BLASTP bit-score cutoff, Loose RGI matches have a bit-score less than the curated BLASTP bit-score cut-off.
Bit-score Cut-off (blastP): 400